Behaviour of the poly(maleic anhydride-co-vinyl acetate) copolymer in aqueous solutions

Nemţoi, Gheorghe; Beldie, Camelia; Tircolea, Carmen; Popa, Iuliana; Creţescu, Igor; Humelnicu, Ionel; Humelnicu, Doina

doi:10.1016/s0014-3057(00)00161-0

Cited by 23 publications

(14 citation statements)

References 18 publications

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“…It is established that a charge‐transfer complex is formed in the styrene maleic anhydride system20–22 which is also supported by our study of zeta potential measurements which indicate that RISUG® is a charged complex, the intensity of which increases on its hydrolysis in saline (Figure 1). The polyelectrolyte nature of the RISUG® particles were also demonstrated by dependence of the reduced viscosity η red to polymer concentration c p as observed in Figure 2 23. This high surface charge density of RISUG® leads to the formation of a complex with ionic biomolecules present in the seminal plasma (Figure 4).…”

Section: Discussionmentioning

confidence: 73%

Study of the micro‐structural properties of RISUG®—A newly developed male contraceptive

et al. 2007

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A new male contraceptive given the name RISUG (an acronym for reversible inhibition of sperm under guidance) and presently undergoing advanced clinical trials has been developed. When injected into the lumen of the vas deferens, its polyelectrolytic nature induces a surface charge imbalance on sperm membrane system leading to the leakage of enzymes essential for fertilization. Contact mode atomic force microscopy (AFM) has been used to analyze quantitatively the micro-structural properties of RISUG and its precipitate in various systems. Hydrolysis of the contraceptive gel resulted in the formation of pores of varying dimensions. RISUG being a highly charged molecule, as evident from zeta potential measurements, has a tendency to form a complex with ionic biomolecules present in the seminal plasma. This is supported by the experimental observations using AFM. This RISUG-biomolecule complex possibly acts as an ionic trap for spermatozoa passing through the vas deferens. Micro-structural properties of RISUG including amplitude (root mean square, peak-to-valley distance, skewness and kurtosis) and spatial roughness have been studied to understand its response to various physiological conditions. Significant alterations in the surface charge distribution of the sperm cell is observed on exposure to RISUG.

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Section: Discussionmentioning

confidence: 73%

Study of the micro‐structural properties of RISUG®—A newly developed male contraceptive

et al. 2007

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“…1 H NMR was then applied to calculate the esterification reaction ratio of the MAn groups (Figure S2c, Supporting Information). The integral areas of δ = 5.3–5.5, 1.8–2.3, and 1.0–1.4 ppm, attributed to H(4), H(3, 6, 14), and H(10, 11), respectively, proved that the vinyl acetates in PMV/Na were fully intact and 49.8% of the MAn groups had reacted with the DAA molecules . The atomic percentages of C, O, and Na in PMV/Na as measured by energy dispersive spectroscopy were 55.74%, 36.41%, and 7.85%, respectively, which verified the results of the esterification reaction ratio of the MAn groups obtained from 1 H NMR data (Figure S2d, Supporting Information).…”

Section: Resultsmentioning

confidence: 93%

A New Family of Photoluminescent Polymers with Dual Chromophores

Guo

et al. 2018

Macromol. Rapid Commun.

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A new family of photoluminescent polymers with dual chromophores is prepared in this study by using poly(maleic anhydride-alt-vinyl acetate), acetone, and metal hydroxide. These polymers, which contain both bulky carboxylic ester groups and metal carboxylate groups, are found to be dual-emission photoluminescent, with a blue luminescence excitation-dependent group and a red luminescence excitation-independent group. These photoluminescence polymers with a nonconjugated structure and dual chromophores also show characteristics of aggregation-induced emission (AIE). The luminous intensities of the AIE fibers prepared using the polymers are found to increase after stretching, in contrast to traditional photoluminescent fibers with the aggregation-caused quenching property. The study also finds that the stretched fibers can emit the three primary colors when irradiated by ultraviolet, blue, and green light.

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“…Finally, as the St monomer was being added gradually, the PVAc/PS composite latex particles were fabricated (Scheme 1d). Under the water, heating, and acerbic conditions, the hydrolysis of the MA monomer was very easy, and this process formed maleic acid [35].…”

Section: Resultsmentioning

confidence: 99%

Fabrication and morphological evolution of inverse core/shell structural latex particles of poly(vinyl acetate)/polystyrene by maleic anhydride grafting

et al. 2016

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In order to overcome the large differences in reactivity ratio and hydrophilicity between vinyl acetate (VAc) monomer and styrene (St) monomer and synthesize a stable poly(vinyl acetate)/polystyrene (PVAc/PS) inverse core/shell (ICS) structural emulsion, this paper presented a novel method to prepare PVAc/PS ICS structural latex particles. Maleic anhydride (MA) grafting, for the first time, was introduced to fabricate the ICS latex particles, where VAc monomer was used as the core monomer and St monomer as the shell monomer. By adjusting the core/shell (CS) ratio and MA content, the morphology of the particles could be controlled to have a regular evolution from strawberry-like to semi-wrapped and final ball-like. In addition, upon MA content exceeding 1 % (percentage of the total monomer), the secondary nucleation almost disappeared gradually. The resulting ICS particles had an average diameter approximately 330 nm and a controllable distribution. Further results of characterization such as phase separation structure, existence of thin transition layer, and special morphological feature of latex particle also demonstrated that this ICS structure had been fabricated successfully. The mechanism of formation was displayed as well.

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Behaviour of the poly(maleic anhydride-co-vinyl acetate) copolymer in aqueous solutions

Cited by 23 publications

References 18 publications

Study of the micro‐structural properties of RISUG®—A newly developed male contraceptive

Study of the micro‐structural properties of RISUG®—A newly developed male contraceptive

A New Family of Photoluminescent Polymers with Dual Chromophores

Fabrication and morphological evolution of inverse core/shell structural latex particles of poly(vinyl acetate)/polystyrene by maleic anhydride grafting

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