This study aimed to evaluate the dry matter yield, nutrient composition, in vitro and methane produced from Megathyrsus maximus (Ntchisi) and Cenchrus purpureus grazed at two grazing frequency (3 and 6-week, (GF)) with two plant spacing (0.5 m x 1 m and 1 m x 1 m). The design of this experiment was split-split plot design in 2 x 2 x 2 factorial arrangement. Milled samples were analyzed for chemical composition, In vitro dry matter digestibility (IVDMD), total gas production, methane (CH 4 ) production, total volatile fatty acid content, content of acetate, butyrate, propionate and acetate: propionate ratio. The M. maximus grazed at 6-week GF with 1 m x 1 m spacing had the highest dry matter yield.The crude protein (CP) content of the grasses ranged from 104.24 -181.35 g/kg DM with C. purpureus grazed at 3-week with 1 m x 1 m spacing ranked highest in CP content and protein fraction A, B 1 , and B 2 . Megathyrsus maximus at 6-week GF with 1 m x 1 m spacing produced the highest content of acid detergent fibre. Metabolizable energy (ME), short chain fatty acid and volume of gas produced at 48 h of incubation was highest for M. maximus grazed at 3-week GF with 0.5 m x 1 m spacing. Megathyrsus maximus at 3 and 6-week GF with 0.5 m x 1 m spacing displayed highest CH 4 value. Acetate, propionate, and total volatile fatty acid were significantly (P<0.05) highest for M. maximus grazed at 6-week with 0.5 m x 1 m spacing.