Behavioural and electrophysiological modulations induced by transcranial direct current stimulation in healthy elderly and Alzheimer’s disease patients: A pilot study

Cespón, Jesús; Rodella, Claudia; Miniussi, Carlo; Pellicciari, Maria Concetta

doi:10.1016/j.clinph.2019.08.016

Cited by 35 publications

(44 citation statements)

References 105 publications

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“…However, this phenomenon was not observed in the MCI group. This finding is consistent with that of prior AD studies (Cespón et al, 2019). To compare the effects of shortand long-term tDCS, Gangemi et al (2020) suggested that if brain stimulation (i.e., tDCS) can be effective with steady-state neurocognitive function over the short term, then this effect could be prolonged for 8 months.…”

Section: Alzheimer's Diseases and Mild Cognitive Impairmentsupporting

confidence: 86%

“…The results revealed that high-frequency power in the temporoparietal area and coherence at the temporalparietal-occipital junction were increased in the AD group. Stimulation was applied in the second study (Cespón et al, 2019) over the left DLPFC, and the return electrode was placed on the right shoulder, with a stimulation duration of 13 min. The working memory, P200 amplitude, and theta band brain activity in the frontal area increased after cathodal tDCS.…”

Section: Alzheimer's Diseases and Mild Cognitive Impairmentmentioning

confidence: 99%

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Systemic Review on Transcranial Electrical Stimulation Parameters and EEG/fNIRS Features for Brain Diseases

2021

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BackgroundBrain disorders are gradually becoming the leading cause of death worldwide. However, the lack of knowledge of brain disease’s underlying mechanisms and ineffective neuropharmacological therapy have led to further exploration of optimal treatments and brain monitoring techniques.ObjectiveThis study aims to review the current state of brain disorders, which utilize transcranial electrical stimulation (tES) and daily usable noninvasive neuroimaging techniques. Furthermore, the second goal of this study is to highlight available gaps and provide a comprehensive guideline for further investigation.MethodA systematic search was conducted of the PubMed and Web of Science databases from January 2000 to October 2020 using relevant keywords. Electroencephalography (EEG) and functional near-infrared spectroscopy were selected as noninvasive neuroimaging modalities. Nine brain disorders were investigated in this study, including Alzheimer’s disease, depression, autism spectrum disorder, attention-deficit hyperactivity disorder, epilepsy, Parkinson’s disease, stroke, schizophrenia, and traumatic brain injury.ResultsSixty-seven studies (1,385 participants) were included for quantitative analysis. Most of the articles (82.6%) employed transcranial direct current stimulation as an intervention method with modulation parameters of 1 mA intensity (47.2%) for 16–20 min (69.0%) duration of stimulation in a single session (36.8%). The frontal cortex (46.4%) and the cerebral cortex (47.8%) were used as a neuroimaging modality, with the power spectrum (45.7%) commonly extracted as a quantitative EEG feature.ConclusionAn appropriate stimulation protocol applying tES as a therapy could be an effective treatment for cognitive and neurological brain disorders. However, the optimal tES criteria have not been defined; they vary across persons and disease types. Therefore, future work needs to investigate a closed-loop tES with monitoring by neuroimaging techniques to achieve personalized therapy for brain disorders.

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Section: Alzheimer's Diseases and Mild Cognitive Impairmentsupporting

confidence: 86%

Section: Alzheimer's Diseases and Mild Cognitive Impairmentmentioning

confidence: 99%

Systemic Review on Transcranial Electrical Stimulation Parameters and EEG/fNIRS Features for Brain Diseases

2021

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“…Estimation of the achieved power for the recruited sample was advisable 92 , particularly when the sample size was not large 88 . A statistical power post hoc analysis was conducted by calculating the Cohen d 93 using the G*Power 3.1 software to determine the level of power that the main outcome (i.e., emotional arousal/ valence) of the present study achieved.…”

Section: Methodsmentioning

confidence: 99%

Sex differences in high-level appreciation of automobile design-evoked gamma broadband synchronization

Wang

Chuang

et al. 2020

Sci Rep

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The present study was conducted to provide neuroimaging correlates for neurodesign of automobile for marketing aesthetics, using event-related spectral perturbations (ERSPs) and participant reports. Thirty men and women aged 22-27 years were presented with various 3-dimensional automobile modelling shapes (rectangular, streamlined, and round), which were cross-matched with various interior colour tones (pure hue/vivid, light, and dark tones) in the experimental conditions, i.e., rectangular exterior with a vivid tone interior. The stimuli pairs were to be rated by participants to facilitate our understanding of the emotional dimensions of automotive design qualities. Significant differences were observed in the high gamma band of 80-100 Hz in the left temporal area between the two sexes. Men elicited a stronger high gamma band signals for dark colour tone interiors and rectangular or round automobile modelling designs because of the meaningful and comprehensible signals associated with the mechanisms of working memory. In contrast, women had fewer reactions than men, and elicited higher beta-band dynamics in the anterior cingulate cortex for rectangular automobile modelling design, and higher gamma-band dynamics for light colour tone interiors, which might relate to their higher self-awareness of positive emotional reward.

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“…Four papers failed to identify a significant effect of tDCS on working memory performance. Cespón et al (41) failed to identify a significant change in reaction time on the N-back task amongst healthy older adults immediately following DLPFC stimulation, and found no unique memory benefits following stimulation [a result that appears to oppose their previous findings; (40)]. That said, anodal tDCS did result in increased P300 amplitudes (a marker of cognitive processing measured using electroencephalography), which correlated with improved accuracy.…”

Section: Working Memorymentioning

confidence: 89%

“…These are summarised in Table 1. By far the most common stimulation method was tDCS (14 papers), of which 10 studies found significant benefits on working memory performance (28,37,38,40,42,44,(46)(47)(48)(49), and 4 did not (29,41,43,45). Across all studies the region most commonly stimulated was the prefrontal cortex (PFC).…”

Section: Working Memorymentioning

confidence: 99%

A Systematic Review of Non-invasive Brain Stimulation Applications to Memory in Healthy Aging

2020

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It has long been acknowledged that memory changes over the course of one's life, irrespective of diseases like dementia. Approaches to mitigate these changes have however yielded mixed results. Brain stimulation has been identified as one novel approach of augmenting older adult's memory. Thus far, such approaches have however been nuanced, targeting different memory domains with different methodologies. This has produced an amalgam of research with an unclear image overall. This systematic review therefore aims to clarify this landscape, evaluating, and interpreting available research findings in a coherent manner. A systematic search of relevant literature was conducted across Medline, PsycInfo, Psycarticles and the Psychology and Behavioral Sciences Collection, which uncovered 44 studies employing non-invasive electrical brain stimulation in healthy older adults. All studies were of generally good quality spanning numerous memory domains. Within these, evidence was found for non-invasive brain stimulation augmenting working, episodic, associative, semantic, and procedural memory, with the first three domains having the greatest evidence base. Key sites for stimulation included the left dorsolateral prefrontal cortex (DLPFC), temporoparietal region, and primary motor cortex, with transcranial direct current stimulation (tDCS) holding the greatest literature base. Inconsistencies within the literature are highlighted and interpreted, however this discussion was constrained by potential confounding variables within the literature, a risk of bias, and challenges defining research aims and results. Non-invasive brain stimulation often did however have a positive and predictable impact on older adult's memory, and thus warrants further research to better understand these effects.

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Behavioural and electrophysiological modulations induced by transcranial direct current stimulation in healthy elderly and Alzheimer’s disease patients: A pilot study

Abstract: Research highlights: 1. tDCS modulated neural activity in healthy elderly and Alzheimer's disease patients. 2. Neural modulations may depend on the interaction between tDCS polarity and neural state. 3. Neural modulations induced by tDCS were related to working memory improvements.

Cited by 35 publications

References 105 publications

Systemic Review on Transcranial Electrical Stimulation Parameters and EEG/fNIRS Features for Brain Diseases

Systemic Review on Transcranial Electrical Stimulation Parameters and EEG/fNIRS Features for Brain Diseases

Sex differences in high-level appreciation of automobile design-evoked gamma broadband synchronization

A Systematic Review of Non-invasive Brain Stimulation Applications to Memory in Healthy Aging

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