Behavioural and neurobiological consequences of 2 different chronic stressors in rats

Dönmez, Refia Aslıhan; Kaya, Fatma Duygu; Derinöz, Okşan; Emmez, Ömer Hakan; Candansayar, Selçuk; Bolay, Hayrünnisa

doi:10.3906/sag-1309-24

Cited by 3 publications

(1 citation statement)

References 44 publications

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“…In one study that compared the behavioral consequences of chronic headache and chronic mild stress in rats, FST was used to observe depressive-like behavior [69]. No significant difference among groups was found regarding the mean duration of climbing, swimming and immobility behavior in FST [69].…”

Section: Affective and Emotional Aspectsmentioning

confidence: 99%

Behavioral and cognitive animal models in headache research

et al. 2019

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Animal models have provided a growing body of information about the pathophysiology of headaches and novel therapeutic targets. In recent years, experiments in awake animals have gained attention as more relevant headache models. Pain can be assessed in animals using behavioral alterations, which includes sensory-discriminative, affective-emotional and cognitive aspects. Spontaneous behavioral alterations such as increased grooming, freezing, eye blinking, wet dog shake and head shake and decreased locomotion, rearing, food or water consumption observed during pain episodes are oftentimes easy to translate into clinical outcomes, but are giving little information about the localization and modality of the pain. Evoked pain response such as tactile and thermal hypersensitivity measures are less translatable but gives more insight into mechanisms of action. Mechanical allodynia is usually assessed with von Frey monofilaments and dynamic aesthesiometer, and thermal allodynia can be evaluated with acetone evaporation test and Hargreaves’ test in animal models. Anxiety and depression are the most frequent comorbid diseases in headache disorders. Anxiety-like behaviors are evaluated with the open-field, elevated plus-maze or light/dark box tests. Interpretation of the latter test is challenging in migraine models, as presence of photophobia or photosensitivity can also be measured in light/dark boxes. Depressive behavior is assessed with the forced-swim or tail suspension tests. The majority of headache patients complain of cognitive symptoms and migraine is associated with poor cognitive performance in clinic-based studies. Cluster headache and tension type headache patients also exhibit a reversible cognitive dysfunction during the headache attacks. However, only a limited number of animal studies have investigated cognitive aspects of headache disorders, which remains a relatively unexplored aspect of these pathologies. Thus, the headache field has an excellent and growing selection of model systems that are likely to yield exciting advances in the future.

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Section: Affective and Emotional Aspectsmentioning

confidence: 99%

Behavioral and cognitive animal models in headache research

et al. 2019

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The effect of depressive-like behavior and antidepressant therapy on social behavior and hierarchy in rats

Boyko

Kutz

Grinshpun

et al. 2019

Behavioural Brain Research

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Stress-Induced Ultrasonic Vocalization in Laboratory Rats and Mice: A Scoping Review

Venkatraman,

Bretl,

Kim

et al. 2024

Brain Sciences

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Introduction: Ultrasonic vocalization (USV) can indicate affective states—including psychosocial stress—in mice and rats. However, stress-induced USV changes could be confounded by laboratory experimental variables such as the type of behavioral stress paradigm, the elicitation method, rodent strain, etc. We sought to provide a review of the current literature to delineate how psychosocial stress-altered rodent USVs may be affected by factors of age, sex, strain, species, elicitation paradigm, and stressor. Methods: We used PubMed, Scopus (Elsevier), PsycINFO (EBSCO), and the following Web of Science (Clarivate) databases: Biological Abstracts, CAB Abstracts, Science Citation Index-Expanded, and Emerging Sources Citation Index. The studies identified by our search strategy were independently screened by two authors with the following inclusion criteria: peer-reviewed, in English, reported original data, and described USV in response to stress in rats or mice. The data extracted included USV acoustic parameters (mean peak frequency and mean amplitude (loudness)), details of the stress and USV elicitation paradigms, rodent species, age, and sex variables. Results: The following screening of 5309 titles/abstracts and 687 full-text articles revealed 148 articles. Footshock (20%), cold exposure (14%), and maternal separation (23.5%) were the most commonly used stress paradigms (duration and type of stressor varied across studies), with the total number of USV calls being the most commonly reported acoustic outcome. In rats, 121 articles described stress-altered USVs, while 25 studies reported the same in mice, and two reported multiple rodent species (rats and mice, alongside other rodent species such as gerbils). With respect to stress-altered USV changes with age, mice and rats increase USV rates after birth, with a peak around 6 to 10 days, and decrease USVs until weanling age. Of the five studies that reported sex-related differences in stress-induced USVs, females had an increased number of calls and lower average peak frequency in response to stress when compared to males. Only two to four studies reported strain-related differences in stress-induced vocalizations in rats and mice, respectively. Conclusions: The data from this review lay the groundwork for better understanding rodent USVs in response to psychosocial stress with effects of elicitation paradigm, stressor, age, and sex.

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Behavioural and neurobiological consequences of 2 different chronic stressors in rats

Cited by 3 publications

References 44 publications

Behavioral and cognitive animal models in headache research

Behavioral and cognitive animal models in headache research

The effect of depressive-like behavior and antidepressant therapy on social behavior and hierarchy in rats

Stress-Induced Ultrasonic Vocalization in Laboratory Rats and Mice: A Scoping Review

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