Behavioural and Neurochemical Effects of Dizocilpine in the Olfactory Bulbectomized Rat Model of Depression

Redmond, A. M.

doi:10.1016/s0091-3057(97)00259-1

Cited by 81 publications

(39 citation statements)

References 29 publications

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“…The open-field test was performed as described previously, 48 and was carried out before stress (0 week), 2 weeks after stress (2 weeks) and 5 weeks after stress (5 weeks). The openfield apparatus consisted of a 100 Â 100 Â 40 cm wooden cuboids, which was covered inside with foil to increase the reflectivity of the walls.…”

Section: Open-field Testmentioning

confidence: 99%

Repeated clomipramine treatment reversed the inhibition of cell proliferation in adult hippocampus induced by chronic unpredictable stress

Liu

Mao-Ying

et al. 2008

Pharmacogenomics J

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Adult hippocampal neurogenesis has been demonstrated in several species and is regulated by both environmental and pharmacological stimuli. Repeated exposure to stress is known to induce the reduction of neurogenesis in the dentate gyrus (DG) of hippocampus. The present study aimed at determining whether the clinically effective antidepressant clomipramine may influence hippocampal proliferation and neurogenesis in adult rats subjected to the chronic unpredictable stress (CUS) procedure, a model of depression with predictive validity. Repeated administration of clomipramine (5 mg kg À1 , intraperitoneal) for 3 weeks, starting 2 weeks after the beginning of the stress procedure, significantly reversed the reduction of behavior measured by open-field test and forced swimming test. Moreover, rats subjected to stress exhibited a 49.9% reduction of cell proliferation at the end of a 5-week stress period, an effect which was suppressed by clomipramine treatment. These results demonstrated that exposure to CUS, which results in a state of behavioral depression, decreases hippocampal cell proliferation and that these effects can be counteracted by chronic clomipramine treatment.

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Section: Open-field Testmentioning

confidence: 99%

Repeated clomipramine treatment reversed the inhibition of cell proliferation in adult hippocampus induced by chronic unpredictable stress

Liu

Mao-Ying

et al. 2008

Pharmacogenomics J

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“…The olfactory bulbectomised (OBX) rat model of depression is one of the well-known rat models of depression in which all behavioural [1][2][3] , anatomical [4,5] , biochemical [3,[6][7][8][9] , and immunological changes [10][11][12][13][14][15] were shown to be similar to those observed in major depression. Moreover, those changes were reversed by chronic, but not acute, antidepressant treatments [3,8,10,[14][15][16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

Effect of the COX-2 Inhibitor Celecoxib on Behavioural and Immune Changes in an Olfactory Bulbectomised Rat Model of Depression

Myint

Steinbusch

Goeghegan

et al. 2007

Neuroimmunomodulation

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Background: The olfactory bulbectomised (OBX) rat model is a chronic model of depression in which behavioural and neuroimmunoendocrine changes are reversed only after chronic antidepressant treatment. The cyclooxygenase 2 (COX-2) inhibitor celecoxib has been shown to improve the depressive symptoms in patients with major depression. Methods: The association between blood and brain immunological and behavioural changes in chronic treatment with COX-2 inhibitor was explored in the OBX rats and their sham-operated controls. Results: The OBX group showed significantly higher locomotor activity than the other groups in the first 5 min in the open field. In the home cage emergence test, the OBX group showed a significantly shorter latency period compared to the sham group (z = –3.192, p = 0.001) but there was no difference between the other three groups. In the hypothalamus, the OBX group had a significantly higher interleukin 1β (IL-1β) concentration than the OBX + celecoxib group (z = –1.89, p = 0.05) as well as a significantly higher IL-10 concentration (z = –1.995, p = 0.046). In the prefrontal cortex, the OBX group showed significantly higher concentrations of tumour necrosis factor α (z = –2.205, p = 0.028) and IL-1β (z = –3.361, p = 0.001) than the OBX + celecoxib group, but a significantly lower concentration of IL-10 (p = –3.361, p = 0.001) than the OBX + celecoxib group. Conclusions: The results of this study supported the potential therapeutic role of the COX-2 inhibitor celecoxib. It is possible that the behavioural changes following the chronic administration of celecoxib to the OBX rats are associated with an attenuation of the increase in the pro-inflammatory cytokines in the brain.

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“…Additionally, memantine and MK-801 were active in chronic unpredictable stress (Ossowska et al, 1997). Also, the antidepressant-like activity of MK-801 was evident in the olfactory bulbectomy model of depression (Redmond et al, 1997). Ro 25-6981, the subunit selective NR 2B antagonist, was found to exhibit rapid (24h) antidepressant-like effect in the FST (Maeng, 2008;Li et al, 2010).…”

Section: The Role Of the Nmda Receptor In The Mechanism Of Action Of mentioning

confidence: 96%

Depression Viewed as a GABA/Glutamate Imbalance in the Central Nervous System

Wierońska¹,

Pałucha-Poniewiera²,

Nowak³

et al. 2012

Clinical, Research and Treatment Approaches to Affective Disorders

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Behavioural and Neurochemical Effects of Dizocilpine in the Olfactory Bulbectomized Rat Model of Depression

Cited by 81 publications

References 29 publications

Repeated clomipramine treatment reversed the inhibition of cell proliferation in adult hippocampus induced by chronic unpredictable stress

Repeated clomipramine treatment reversed the inhibition of cell proliferation in adult hippocampus induced by chronic unpredictable stress

Effect of the COX-2 Inhibitor Celecoxib on Behavioural and Immune Changes in an Olfactory Bulbectomised Rat Model of Depression

Depression Viewed as a GABA/Glutamate Imbalance in the Central Nervous System

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