2016
DOI: 10.1016/j.forsciint.2015.12.035
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Behavioural and pharmacological characterization of a novel cannabinomimetic adamantane-derived indole, APICA, and considerations on the possible misuse as a psychotropic spice abuse, in C57bl/6J mice

Abstract: The novel adamantane derivative APICA (N-(adamantan-1-yl)-1-pentyl-1H-indole-3-carboxamide) was recently identified as a cannabinomimetic indole of abuse. Despite its novel structure, APICA recalls cannabinomimetic indoles, such as representative member JWH-018.In present study, the effects of APICA (1-3 mg/kg, i.p.) were tested in C57BL/6J mice, in the Tetrad task which includes the assessment of: body temperature; locomotor activity and behavioural reactivity; nociception; motor coordination; declarative mem… Show more

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Cited by 17 publications
(20 citation statements)
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“…The open-field arena is a Plexiglas square box (44 × 44 × 44 cm where locomotor activity and explorative behavior were measured) by employing an automatic video-tracking system (AnyMaze, Ugo Basile, Italy), in a mean light- (100 lx) illuminated chamber. Each experimental session lasted 5 min (Cannizzaro et al, 2016 ). The video-tracking system produces a quali-quantitative mapping of the motor pattern, measuring total distance traveled (TDT, m), as a measure of locomotor activity in a novel environment.…”
Section: Methodsmentioning
confidence: 99%
“…The open-field arena is a Plexiglas square box (44 × 44 × 44 cm where locomotor activity and explorative behavior were measured) by employing an automatic video-tracking system (AnyMaze, Ugo Basile, Italy), in a mean light- (100 lx) illuminated chamber. Each experimental session lasted 5 min (Cannizzaro et al, 2016 ). The video-tracking system produces a quali-quantitative mapping of the motor pattern, measuring total distance traveled (TDT, m), as a measure of locomotor activity in a novel environment.…”
Section: Methodsmentioning
confidence: 99%
“…SC demonstrates also interactions with other transmission systems, namely µ-opioid [55], glutamate and GABA [56]. Meanwhile, for some SC agents abuse potential contributes also to alteration in neurobiological function, cognitive potency or behaviour without significant influence on rewarding or reinforcing systems [57][58]. Overall, SC activity at non-cannabinoid receptors may well contribute to the complex clinical effects observed [5].…”
Section: Pharmacologymentioning
confidence: 99%
“…The cannabinoid agonist WIN 55, 212-2 mesylate (WIN; Tocris Bioscience, UK) and the CB1 receptor antagonist AM281 (Sigma, Italy) were initially dissolved in 3% ethanol; followed by 3% Tween 20 and 94% saline (Cannizzaro et al, 2016). WIN was administered intraperitoneally (i.p.)…”
Section: Drugsmentioning
confidence: 99%