Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: Specific deficits in ‘waiting’ versus ‘stopping’

Robinson, Emma; Eagle, Dawn M.; Economidou, Daina; Theobald, DE; Mar, Adam C.; Murphy, Emily R.; Robbins, Trevor W.; Dalley, Jeff

doi:10.1016/j.bbr.2008.09.021

Cited by 167 publications

(132 citation statements)

References 54 publications

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“…The differences in premature responding reported here are not the result of artefacts unrelated to impulsivity; recent work on Lister-Hooded rats selected for differences in impulsive behavior, showed similar baselines values of premature responding on the 5-CSRT task to those showed by RHA-I and RLA-I animals in the present experiment (Robinson et al, 2009). In fact, premature responses in both groups were above and below, respectively, the normal average for Wistar and Sprague-Dawley rats (Moreno et al, unpublished data from our laboratory; van Gaalen et al, 2006).…”

Section: Increased Adjunctive Drinking Acquisition In Rha-i Ratssupporting

confidence: 75%

“…The 5-CSRT task measures parameters related to attention and inhibitory control of impulsive actions, such as premature responses (Robbins, 2002;Robinson et al, 2009;Winstanley et al, 2006). In spite of the absence of betweenstrain differences in accuracy, RHA-I rats showed an increased number of premature responses compared with RLA-I rats.…”

Section: Increased Adjunctive Drinking Acquisition In Rha-i Ratsmentioning

confidence: 99%

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Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Moreno

Cardona

Gómez

et al. 2010

Neuropsychopharmacol

134

106

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The selective breeding of Roman high-(RHA) and low-avoidance (RLA) rats for rapid vs extremely poor acquisition of active avoidance behavior in a shuttle-box has generated two phenotypes with different emotional and motivational profiles. The phenotypic traits of the Roman rat lines/strains (outbred or inbred, respectively) include differences in sensation/novelty seeking, anxiety/fearfulness, stress responsivity, and susceptibility to addictive substances. We designed this study to characterize differences between the inbred RHA-I and RLA-I strains in the impulsivity trait by evaluating different aspects of the multifaceted nature of impulsive behaviors using two different models of impulsivity, the delay-discounting task and five-choice serial reaction time (5-CSRT) task. Previously, rats were evaluated on a schedule-induced polydipsia (SIP) task that has been suggested as a model of obsessive-compulsive disorder. RHA-I rats showed an increased acquisition of the SIP task, higher choice impulsivity in the delay-discounting task, and poor inhibitory control as shown by increased premature responses in the 5-CSRT task. Therefore, RHA-I rats manifested an increased impulsivity phenotype compared with RLA-I rats. Moreover, these differences in impulsivity were associated with basal neurochemical differences in striatum and nucleus accumbens monoamines found between the two strains. These findings characterize the Roman rat strains as a valid model for studying the different aspects of impulsive behavior and for analyzing the mechanisms involved in individual predisposition to impulsivity and its related psychopathologies.

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Section: Increased Adjunctive Drinking Acquisition In Rha-i Ratssupporting

confidence: 75%

Section: Increased Adjunctive Drinking Acquisition In Rha-i Ratsmentioning

confidence: 99%

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Moreno

Cardona

Gómez

et al. 2010

Neuropsychopharmacol

134

106

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“…34 By means of various genetic tools, pharmacological manipulations, lesion studies and many other interventions the neuroanatomical, neurochemical, molecular and genetic basis of behavioural traits can be examined. This is exemplified by a recent study in rats selected for high impulsivity showing that trait impulsivity and vulnerability to cocaine-taking is mediated in part by Dopamine D2/3 receptor density in the nucleus accumbens.…”

Section: Introductionmentioning

confidence: 99%

The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology

et al. 2010

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A fundamental function of the brain is to evaluate the emotional and motivational significance of stimuli and to adapt behaviour accordingly. The IMAGEN study is the first multicentre genetic-neuroimaging study aimed at identifying the genetic and neurobiological basis of individual variability in impulsivity, reinforcer sensitivity and emotional reactivity, and determining their predictive value for the development of frequent psychiatric disorders. Comprehensive behavioural and neuropsychological characterization, functional and structural neuroimaging and genome-wide association analyses of 2000 14-year-old adolescents are combined with functional genetics in animal and human models. Results will be validated in 1000 adolescents from the Canadian Saguenay Youth Study. The sample will be followed up longitudinally at the age of 16 years to investigate the predictive value of genetics and intermediate phenotypes for the development of frequent psychiatric disorders. This review describes the strategies the IMAGEN consortium used to meet the challenges posed by largescale multicentre imaging-genomics investigations. We provide detailed methods and Standard Operating Procedures that we hope will be helpful for the design of future studies. These include standardization of the clinical, psychometric and neuroimaging-acquisition protocols, development of a central database for efficient analyses of large multimodal data sets and new analytic approaches to large-scale genetic neuroimaging analyses.

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“…Recent conceptualizations have categorized impulsivity in terms of deficiencies in decision-making, inhibitory response control (for example, stopping) and in bridging delays to future rewards (Winstanley et al, 2006;Dalley et al, 2007;Pattij and Vanderschuren, 2008;Eagle et al, 2008;Robinson et al, 2009). Although the neural substrates of impulsivity are only partly understood, considerable evidence points to a significant involvement of the nucleus accumbens (NAcbs) Pattij and Vanderschuren, 2008), a forebrain region involved in the integration and expression of motivated behavior (Mogenson et al, 1980;Robbins and Everitt, 1996).…”

Section: Introductionmentioning

confidence: 99%

Dissociable Control of Impulsivity in Rats by Dopamine D2/3 Receptors in the Core and Shell Subregions of the Nucleus Accumbens

Besson

Belin

McNamara

et al. 2009

Neuropsychopharmacol

122

111

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Previous research has identified the nucleus accumbens (NAcb) as an important brain region underlying inter-individual variation in impulsive behavior. Such variation has been linked to decreased dopamine (DA) D2/3 receptor availability in the ventral striatum of rats exhibiting spontaneously high levels of impulsivity on a 5-choice serial reaction time (5-CSRT) test of sustained visual attention. This study investigated the involvement of DA D2/3 receptors in the NAcb core (NAcbC) and the NAcb shell (NAcbS) in impulsivity. We investigated the effects of a DA D2/3 receptor antagonist (nafadotride) and a DA D2/3 partial agonist (aripiprazole) infused directly into either the NAcbC or NAcbS of rats selected for high (HI) and low (LI) impulsivity on the 5-CSRT task. Nafadotride increased significantly the level of impulsivity when infused into the NAcbS, but decreased impulsivity when infused into the NAcbC of HI rats. By contrast, intraNAcb microinfusions of aripiprazole did not affect impulsivity. Systemic administration of nafadotride had no effect on impulsive behavior but increased the number of omissions and correct response latencies, whereas systemic injections of aripiprazole decreased impulsive and perseverative behavior, and increased the number of omissions and correct response latencies. These findings indicate an opponent modulation of impulsive behavior by DA D2/3 receptors in the NAcbS and NAcbC. Such divergent roles may have relevance for the etiology and treatment of clinical disorders of behavioral control, including attention-deficit hyperactivity disorder and drug addiction.

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Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: Specific deficits in ‘waiting’ versus ‘stopping’

Cited by 167 publications

References 54 publications

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology

Dissociable Control of Impulsivity in Rats by Dopamine D2/3 Receptors in the Core and Shell Subregions of the Nucleus Accumbens

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