Behavioural correlates of early‐treated congenital hypothyroidism

Kooistra, Libbe; Stemerdink, N.; Meere, van der Jacob; Vulsma, Thomas; Kalverboer, Alex

doi:10.1111/j.1651-2227.2001.tb03244.x

Cited by 24 publications

(11 citation statements)

References 24 publications

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“…The higher percentage of CH patients than of their healthy peers still living with parents may reflect lower patient maturity and autonomy, as reported for young adult patients with chronic conditions of childhood onset (37). It may also reflect parental stress or the association of particular types of social behavior with personality disorders (38). For example, some young adults with CH present depressive moods or anxiety (39, 40), requiring psychological support and counseling.…”

Section: Cognition Behavior and Socioeducational Attainmentmentioning

confidence: 99%

ENDOCRINOLOGY AND ADOLESCENCE: Congenital hypothyroidism: a clinical update of long-term outcome in young adults

Léger

2015

European Journal of Endocrinology

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Congenital hypothyroidism (CH) is the most common congenital endocrine disorder. The early treatment of CH patients has successfully improved the prognosis and management of this disorder. Optimal treatment and management throughout the patient's life, beginning in the neonatal period, are required to ensure long-term health. Affected patients should be offered assessments of associated medical conditions and provided with accurate information about their condition throughout their lives, but particularly during the transition from pediatric to adult services. This review provides a summary of current knowledge about the long-term outcomes of these patients and appropriate management into early adulthood. We carried out a systematic search of the Medline database to identify relevant articles. Despite major improvements in prognosis, the impact of CH is clearly not uniform, and management should take into account a broader range of relevant indicators, including CH severity, associated comorbid conditions and the adequacy of treatment during childhood and adulthood. The early diagnosis and management of associated medical conditions, and better educational strategies to improve compliance with treatment, should improve the long-term prognosis. Further studies are required to explore changes with aging.

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Section: Cognition Behavior and Socioeducational Attainmentmentioning

confidence: 99%

ENDOCRINOLOGY AND ADOLESCENCE: Congenital hypothyroidism: a clinical update of long-term outcome in young adults

Léger

2015

European Journal of Endocrinology

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“…According to the data from recent literature (14,18), parents of children in the latency age reported the most behavioural problems. There may be different reasons to explain this increase in behavioural problems in parents' opinion: it is likely that at this age, starting school emphasises the problem of comparison with healthy peers in terms of scholastic performance requiring cognitive competence.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have evaluated the quality of life of young adults with CH diagnosed by neonatal screening but the results are controversial (12,13). The limited literature has shown that children and adolescents with early-treated CH have more behavioural problems, particularly in the areas of introversion and social negativity, than normal controls (14).…”

Section: Introductionmentioning

confidence: 99%

Psychological and behavioural aspects in children and adolescents with congenital hypothyroidism diagnosed by neonatal screening: comparison between parents' and children's perceptions

Bisacchi¹,

Bal²,

Nardi³

et al. 2011

European Journal of Endocrinology

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Objective: To compare the psychological adjustment and behaviour of congenital hypothyroidism (CH) children and their parents with a control group. Study design: A cross-sectional study was carried out with 84 CH subjects diagnosed by neonatal screening (range 2.7-18.6 years), subdivided into four age groups: group 1 (2-5 years); group 2 (6-10 years); group 3 (11-13 years); and group 4 (14-18 years) and was compared with an age-matched control group. Patients were assessed using two questionnaires: Child Behaviour Checklist for parents and Youth Self-Report for children over 11 years of age. Results: In groups 1, 3 and 4, total score (TS), internalising score (ISZproblems within the self) and externalising score (ESZconflicts with other people) as reported by parents were not significantly different in CH patients and in controls. In group 2, parents of CH children showed values of TS (P!0.05), IS (P!0.05), ES (P!0.05) and scores on other scales significantly higher than controls. In self-reports of groups 3 and 4, the behavioural scales were not significantly different in CH patients and in controls. Conclusions: Paediatricians should be informed about the increased risk of the development of behavioural problems at primary school age in CH patients. At this age special attention should be paid to parental worries and anxiety. However, it can be reassuring for the patients and parents to know that the problems may be related to CH, and that they may spontaneously disappear.

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“…Parents also identified speech problems as being major areas of concern. 27 The CH patients cannot reach the mental development expected according to age. Patients receiving treatment after a delayed diagnosis may gain the skills to improve their daily functioning and engage in more physical activity.…”

Section: Discussionmentioning

confidence: 99%

Delayed diagnosis of congenital hypothyroidism in an adolescent results in avoidable complications: a case report

Ihsan

Rini

2017

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Delayed diagnosis of congenital hyporhyroidism (CH) remains a serious problem. A retrospective analysis of 1,000 CH cases in Turkey found a mean age of 49 months at the time of clinical diagnosis. Only 3.1% of cases were diagnosed during the neonatal period and 55.4% were diagnosed after 2 years of age.1 In Cipto Mangunkusumo Hospital, Jakarta, 53% cases were diagnosed at 1-5 years, 3.3% at 6-12 years, and 6.7% after 12 years of age, while the remainder were diagnosed at < 1 year of age.2 The majority of affected children exhibit signs and symptoms that are highly non-specific, as most infants with CH are asymptomatic at birth, and only 5% of cases can be diagnosed based on clinical examination during the first day of life.3 The other factors that contribute to delayed diagnosis are uneducated parents, who do not notice or dismiss the importance of mild/moderate deviations in physical and mental growth, as well as constipation, feeding difficulties, or other vague, non-specific symptoms in infancy. Parents are often unaware of the importance of early diagnosis and commencement of therapy for CH.4

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Behavioural correlates of early‐treated congenital hypothyroidism

Cited by 24 publications

References 24 publications

ENDOCRINOLOGY AND ADOLESCENCE: Congenital hypothyroidism: a clinical update of long-term outcome in young adults

ENDOCRINOLOGY AND ADOLESCENCE: Congenital hypothyroidism: a clinical update of long-term outcome in young adults

Psychological and behavioural aspects in children and adolescents with congenital hypothyroidism diagnosed by neonatal screening: comparison between parents' and children's perceptions

Delayed diagnosis of congenital hypothyroidism in an adolescent results in avoidable complications: a case report

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