Abstract:Introduction: In Ethiopia, HIV epidemic has been seen even in hard-to-reach and pastoralist communities. But the pattern and distribution of HIV greatly varies by various parameters like region, place of residence and sex. Even though it is a public health problem of all segment of the population, the epidemic among youth and economically active segment of the community is the fastest growing partly because of young people's vulnerability and because of low use of preventive services like correct and consistent condom use. Objectives: Assessment of determinants of correct and consistent condom use among Mizan-Tepi University students, southern, Ethiopia, 2011. Methods: Institutional based cross-sectional study design triangulated with qualitative study design was conducted. Data was collected from 421 randomly selected regular students using pretested structured questionnaire through interview. Coded, entered, cleaned and analyzed using SPSS version 16 Summary statistics of socio demographic variables were presented using frequency tables and graphs. A logistic regressions analysis method was employed. Odds ratio with 95% confidence interval was used to assess the association of dependent and independent variables. P-value less than 5% was taken into consideration to say there determinant factor. Results: A total of 421 students were participated in the study making the response rate 90.2%. Out of the total respondents 301 (71.5%) were males. The mean age of the study population was 17.3 with standard deviation of 2.41 years. The level of correct and consistent use of condom in the study is 43.3%. Age at first sexual intercourse, number of sexual partner and own risk perception was found to be associated with correct and consistent use of condom. Conclusion: The overall prevalence of correct and consistent condom use is 43.3%. Age at first sexual intercourse, number of sexual partner and own risk perceptions were found to be significant determinants of correct and consistent use of condom.