Behavioural Representation of the Aorta by Utilizing Windkessel and Agent-Based Modelling

Abstract

The main objective of the present paper is to report two studies on mathematical and computational techniques used to model the behaviour of the aorta in the human cardiovascular system. In this paper, an account of the design and implementation of two distinct models is presented: a Windkessel model and an agent-based model. Windkessel model represents the left heart and arterial system of the cardiovascular system in the physiological domain. The agent-based model offers a simplified account of arterial behaviour by randomly generating arterial parameter values. This study has described the mechanism how and when the left heart contracts and pumps the blood out of the aorta, and it has taken the Windkessel model one step further. The results of this study show that the dynamics of the aorta can be explored in each modelling approaches as proposed and implemented by our research group. It is thought that this study will contribute to the literature in terms of development of the Windkessel model by considering its timing and redesigning it with digital electronics perspective.

Computational Fluid Dynamics and Numeric Analysis of Aortic Wall Shear Stress Alterations Induced by Fatty Streaks

“…For instance, research utilizing ANSYS CFX for CFD simulations has illuminated the significant correlation between simulated arterial characteristics and actual measurements of arterial lumen area, wall area, and plaque burden, reinforcing the hypothesis that regions subjected to low ESS are hotspots for plaque accumulation and growth. In contrast, innovative mathematical and agent-based modeling techniques have offered alternative perspectives on cardiovascular dynamics, enriching our understanding of the systemic nature of atherosclerosis [4][5][6].…”