Behavioural sensitization to alcohol: Bridging the gap between preclinical research and human models

Nona, Christina N.; Hendershot, Christian S.; Lê, A. D.

doi:10.1016/j.pbb.2018.08.003

Cited by 14 publications

(23 citation statements)

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“…motivational) properties of alcohol and its predictive cues. Resulting behavioral manifestations include cue-elicited approach, attentional biases and subjective craving [3,4]. Pre-clinical work suggests that the propensity to attribute incentive value to reward cues, indexed by a cue-directed, cue-elicited approach [i.e.…”

Section: Introductionmentioning

confidence: 99%

Behavioral response bias and event‐related brain potentials implicate elevated incentive salience attribution to alcohol cues in emerging adults with lower sensitivity to alcohol

et al. 2021

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Aims This study used a behavioral approach‐avoidance task including images of alcoholic beverages to test whether low sensitivity to alcohol (LS) is a phenotypical marker of a dispositional propensity to attribute bottom‐up incentive value to naturally conditioned alcohol cues. Design, setting and participants Experimental study with a measured individual difference variable at a university psychology laboratory in Missouri, MO, USA. Participants were 178 emerging adults (aged 18–20 years) varying in self‐reported sensitivity to alcohol's acute effects. Measurements Participants completed the alcohol approach‐avoidance task while behavior (response time; RT) and the electroencephalogram (EEG) were recorded. Stimulus‐locked event‐related potentials (ERPs) provided indices of integrated (top‐down and bottom‐up) stimulus incentive value (P3 amplitude) and conflict between top‐down task demands and bottom‐up response propensities (N450 amplitude). Findings Linear mixed models showed faster RT for ‘alcohol‐approach’ relative to ‘alcohol‐avoid’ trials for lower‐sensitivity (LS) [meanD ± standard errorD (MD ± SED) = 29.51 ± 9.74 ms, t(328) = 3.03, P = 0.003] but not higher‐sensitivity (HS) individuals (MD ± SED = 2.27 ± 9.33 ms, t(328) = 0.243, P = 0.808). There was enhanced N450 amplitude (response conflict) for alcohol‐avoid relative to alcohol‐approach trials for LS participants (MD ± SED = 0.811 ± 0.198 μV, Z = 4.108, P < 0.001) and enhanced N450 amplitude for alcohol‐approach relative to alcohol‐avoid for HS participants (MD ± SED = 0.419 ± 0.188 μV, Z = 2.235, P = 0.025). There was also enhanced P3 amplitude for alcohol‐approach relative to alcohol‐avoid for LS (MD ± SED = 0.825 ± 0.204 μV, Z = 4.045, P < 0.001) but not HS (MD ± SED = 0.013 ± 0.194 μV, Z = 0.068, P = 0.946). Conclusions Findings from a human laboratory study appear to support the notion that low sensitivity to alcohol indexes a propensity to attribute bottom–up incentive value to naturally conditioned alcohol cues.

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Section: Introductionmentioning

confidence: 99%

Behavioral response bias and event‐related brain potentials implicate elevated incentive salience attribution to alcohol cues in emerging adults with lower sensitivity to alcohol

et al. 2021

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“…It is noteworthy that other studies do not report positive correlation between sensitization to cocaine and drug-seeking behavior and thus suggest a dissociation between psychomotor sensitization and compulsive use. 21 Regarding ethanol, numerous studies yielded inconsistent results using voluntary ethanol intake assessed in a two-bottle choice paradigm (see Nona et al 22 for review). Mixed results may come from the fact that measuring ethanol drinking using a two-bottle choice paradigm may not be appropriate to capture an increase in the motivational aspects of the drinking behavior.…”

Section: Introductionmentioning

confidence: 99%

“…In light of the controversy over the link between EIBS and alcohol addiction and because to our knowledge no study yet investigated the influence of ethanol sensitization on subsequent ethanol intake using an operant paradigm, the main goal of the present study was to assess the motivation to self-administer ethanol using an operant paradigm after the induction of sensitization in outbred mice. Our strategy was to compare EIBS-prone with EIBS-resistant outbred mice as it is now usual in the field to separate high-and low-sensitized groups in order to study epigenetic factors that may contribute to the individual differences (see Nona et al 22 for review). Furthermore, since alcoholinduced behaviors are mediated partly by neuronal activity in nucleus accumbens and caudate putamen, [36][37][38] the second objective of this study was to evaluate alcohol-induced changes in c-Fos expression in these brain regions and determine whether Fos expression is related to the level of EIBS during the expression phase (ie, after an ethanol challenge 1 week after the end of the induction phase).…”

Section: Introductionmentioning

confidence: 99%

“…Regarding ethanol, numerous studies yielded inconsistent results using voluntary ethanol intake assessed in a two‐bottle choice paradigm (see Nona et al 22 for review). Mixed results may come from the fact that measuring ethanol drinking using a two‐bottle choice paradigm may not be appropriate to capture an increase in the motivational aspects of the drinking behavior.…”

Section: Introductionmentioning

confidence: 99%

“…34 Mixed results on the association between sensitization and subsequent drug intake may be explained by procedural aspects. In this regard, the importance of selfadministration paradigm used has been highlighted in a recent review 22 since it may have an important bearing on the results and subsequent interpretations.…”

Section: Introductionmentioning

confidence: 99%

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Vulnerability to ethanol sensitization predicts higher intake and motivation to self‐administer ethanol: Proof of the incentive salience sensitization theory?

2019

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Ethanol-induced behavioral sensitization (EIBS) is thought to play a key role in addiction. However, whether EIBS is linked to an increase in the motivation to selfadministerethanol in an operant paradigm has never been demonstrated, and thus, the motivational sensitization theory (increase in drug wanting) has not been yet confirmed. We investigated using the operant ethanol self-administrationparadigm if the motivation to self-administerethanol (breakpoint) is increased in female mice prone to develop EIBS. Outbred female Swiss mice were treated once a day with 2.5-g ethanol per kilogram during 10 days and challenged with the same dose of ethanol 7 days later. EIBS-pronegroup was characterized by a significant increase in locomotion between the challenge day and day 1. When the difference was not significant, mice were considered as the "EIBS-resistant"group. Mice were then trained to nose poke for a 20% ethanol solution reinforcer under a FR1 and then a FR-2schedule of reinforcement. Motivation was assessed more directly with a progressive ratio schedule. Our results show that there is a positive correlation between EIBS and both the level of intake and motivation. Interestingly, acquisition of ethanol self-administrationwas faster in sensitized mice that also display a quick and long-lastingincrease in ethanol intake together with a lack of effect of alcohol challenge on c-Fosexpression restricted to the dorsolateral striatum. These results further support that EIBS vulnerability is crucial in the development of addictive behaviors and suggest a potential link with habit learning processes.

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Potential of GABAB Receptor Positive Allosteric Modulators in the Treatment of Alcohol Use Disorder

Maccioni

Colombo

2019

CNS Drugs

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Behavioural sensitization to alcohol: Bridging the gap between preclinical research and human models

Cited by 14 publications

References 200 publications

Behavioral response bias and event‐related brain potentials implicate elevated incentive salience attribution to alcohol cues in emerging adults with lower sensitivity to alcohol

Behavioral response bias and event‐related brain potentials implicate elevated incentive salience attribution to alcohol cues in emerging adults with lower sensitivity to alcohol

Vulnerability to ethanol sensitization predicts higher intake and motivation to self‐administer ethanol: Proof of the incentive salience sensitization theory?

Potential of GABAB Receptor Positive Allosteric Modulators in the Treatment of Alcohol Use Disorder

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