Behavioural Study of Cyclodextrin Inclusion Complex on Enhancement of Solubility of Aceclofenac

Abstract

The main objective of the present study was to enhance the solubility and dissolution rate of poorly water soluble aceclofenac using its solid dispersion with β-cyclodextrin. FTIR and DSC study was carried out to find out any incompatibility. The phase solubility of drug was carried out in 1, 2, 5, and 10% of β-cyclodextrin in distilled water. Kneading method and solvent evaporation method was use to prepared solid dispersion of aceclofenac and β-cyclodextrin. Different evaluation tests like solubility study in different solvents, PXRD and in vitro dissolution study of aceclofenac- β-cyclodextrin inclusion complex were carried out. The overall finding indicated that β-cyclodextrin is a desirable water soluble carrier, that helps in increasing solubility of drug. Due to its structural feature, β-cyclodextrin forms a good inclusion complex that decreases contact angle of drug with water molecules by increasing wetting properties. Hence, it can be concluded that, β-cyclodextrin is better water soluble carrier molecule in terms of its compatibility and increasing solubility behavior of poorly water soluble drug aceclofenac.

Recovery, reusability and stability studies of beta cyclodextrin used for cholesterol removal from shrimp lipid

“…Thermal studies of β-CD with aceclofenac inclusion complex supports the present study that β-CD exhibited a melting peak at 109 °C. 21 Although both the peaks were found in the same range, slight reduction was noted in the R-β-CD. The temperature difference indicated that β-CD might undergo slight modification after cholesterol removal and during recycling process.…”

Synthesis and Characterization of Novel β-CD-Xanthate and Its Application in the Treatment of Heavy Metal Containing Wastewater and Lignin Enriched Paper Industry Wastewater

“…The DSC curve for -CD and -CDX3 were demonstrated in Figure 4 (c). Figure 4 (c) states that the endothermic peak of -CD observed at around 93 o C its melting point [30] that means -CD is heat absorbed, but in case of -CDX3 the multiple exothermic peaks observed at 55, 236, 260 & 399 o C. The major exothermic peak of -CDX3 were occurred at around 236 o C its melting point that means -CDX3 is heat released. From above observation it is clear that the -CDX3 is quite stable than that of -CD.…”

Surface Modification of Bi2O3 Nanoparticles with Biotinylated β-Cyclodextrin as a Biocompatible Therapeutic Agent for Anticancer and Antimicrobial Applications

“…The relationship between the temperature change and mass loss is expressed using DSC (Differential Scanning Calorimetry) and the DSC plot of the surface-modified Bi 2O3 NP system is shown in Figure 5 [41][42][43]. On increasing the temperature from room temperature, in the DSC plot, an endothermic peak was observed where the onset temperature, the peak temperature, and the end set temperature are at 54.22 °C, 78.19 °C, and 104.23 °C, respectively.…”