Behçet's disease and cardiac arrhythmia

Mirone, L.; Altomonte, L; Ferlisi, E. M.; Zoli, Angelo; Magarò, M.

doi:10.1007/bf02238772

Cited by 10 publications

(9 citation statements)

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“…Albeit rare, cardiac involvement in Behç et's disease may present with arrhythmias, such as paroxysmal atrial tachycardia, premature ventricular beat, or conduction disturbances. 33,[38][39][40] In this series, complete heart block occurred in one patient preoperatively and two postoperatively, necessitating implantation of a permanent pacemaker. The real reason of heart rhythm disturbance was not clarified and might result from inflammation of the conduction system.…”

Section: Discussionmentioning

confidence: 78%

Aortic Regurgitation Caused by Behçet's Disease: Surgical Experience during an 11-Year Period

Zheng

Zhu

et al. 2012

Journal of Cardiac Surgery

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Section: Discussionmentioning

confidence: 78%

Aortic Regurgitation Caused by Behçet's Disease: Surgical Experience during an 11-Year Period

Zheng

Zhu

et al. 2012

Journal of Cardiac Surgery

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“…Cardiac involvement in BD may present with arrhythmia such as paroxysmal atrial tachycardia, premature ventricular beat, or conduction defects 12 …”

Section: Discussionmentioning

confidence: 99%

“…11 Cardiac involvement in BD may present with arrhythmia such as paroxysmal atrial tachycardia, premature ventricular beat, or conduction defects. 12 The other cardiovascular involvement of surgical importance is aortic root dilatation and aortic insufficiency, 13 which may need root replacement.…”

Section: Discussionmentioning

confidence: 99%

Cardiac and Great Vessel Involvement in “Behcet's Disease”

Marzban

Mandegar

Karimi

et al. 2008

Journal of Cardiac Surgery

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Behcet's disease is a multisystem disorder and classified as "vasculitic syndrome with a wide variety of clinical manifestations." Cardiac involvement is very rare but can occur with different presentations including: pericarditis, cardiomyopathy, endocarditis, endomyocardial fibrosis, intracavitary thrombosis, and coronary artery disease. Great vessel involvement is more common. Recurrent Phlebitis, commonly involving large vessels (superior vena cava, inferior vena cava, hepatic veins) and cerebral veins are the sole presentation in this regard. Arterial involvement is expressed by aneurysm or pseudoaneurysmal formation. Due to the wide variety of cardiovascular manifestations and the resulting high mortality, cardiac surgeons should be familiar with this disease. In this paper we review the articles and introduce our four cases presenting with aneurysm of ascending aorta with free aortic insufficiency, aneurysm of descending aorta, pulmonary artery aneurysm, and pseudoaneurysm of aortic arch. doi: 10.1111/j. 1540-8191.2008.00607.x (J Card Surg 200823:765-768) Behcet's disease (BD) was first discovered in 1937 by Hulusi Behcet. It is an autoimmune disease and is classified as a vasculitic syndrome. This disease is a multisystem disorder with a wide variety of clinical manifestations including skin, eye, musculoskeletal, neurologic, and cardiovascular presentations. 1,2 The spectrum of cardiac diseases may include pericarditis, coronary artery stenosis or aneurysm, myocarditis, cardiomyopathy, congestive heart failure, valvular pathology, endocarditis or endocavitary thrombosis, aneurysm of aorta and its branches, pulmonary artery aneurysm, or venous thrombosis. Due to its wide variety of pathologies, disease presentation may vary in each case. CASE REPORT Case 1A 24-year-old man, a known case of BD, under followup by the rheumatology clinic in our center, developed exertional chest pain a few weeks prior to presentation to our ward. His workup, including chest xray (CXR), computed tomography (CT) scan, transthoracic echocardiography, and aortography, showed cardiomegaly, severe aortic insufficiency, and a huge aneurysm of ascending aorta as is shown in (Fig. 1). aortic valve no. 23. The patient had a smooth postoperative course and an uneventful recovery, but 20 days postoperative the patient was operated on once again Address for correspondence: Mehrab Marzban, M.D., Tehran Heart Center, Tehran, Iran. Fax: +98-21-88029256; e-mail: mehrabmarzban2007@yahoo.com due to massive pericardial effusion resulting from subxiphoid drainage. Now, two years postoperative, the patient is on maintenance prednisolone therapy. Case 2A 50-year-old woman, a known case of BD with cutaneous and ocular manifestation on prednisolone and colchicine, presented to our center with a history of upper abdominal pain, mild dysphagia, and weight loss for a few weeks. Her workup, including CXR, echocardiography, CT scan, and aortogram, showed a saccular aneurysm of descending aorta, just above the diaphragm (Fig. 2). The patient...

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“…A few case reports have indicated pleural effusion due to primary vasculitis of the pleura (6). Cardiovascular involvement, including coronary artery disease, pericarditis, myocarditis, endocarditis, arrhythmia and valvular dysfunction, have been reported in <10% of patients with Behçet's disease (9)(10)(11). Pericardial involvement, a common cardiac manifestation with up to 40% cardiac involvement, may be associated with vasculitis of the pericardium or SVC thrombosis (6,10).…”

Section: Introductionmentioning

confidence: 99%

A 30-year-old female Behçet’s disease patient with recurrent pleural and pericardial effusion and elevated adenosine deaminase levels: case report

et al. 2016

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Behçet's disease is a systemic disease which may involve various organs. We describe a case of a patient diagnosed as pleuropericardial involvement of Behçet's disease. A 30-year-old woman visited our clinic presented with left pleuritic chest pain for s days. She had been diagnosed as Behçet's disease and admitted to our clinic due to pericardial and pleural effusion repeatedly in past two years. In the previous studies, effusion analysis revealed to be lympho-dominant exudate with high adenosine deaminase level. Acid-fast bacilli (AFB) culture and polymerase chain reaction (PCR) for mycobacterial tuberculosis (M.TB) were negative in the pericardial tissue, and pathologic finding showed mild endothelitis with micro-thrombi formation in the lumen. The patient had been treated with antituberculous medication for a year. In the current admission, chest computed tomography (CT) again showed left pleural effusion without other significant lesion. Pleural fluid analysis was similar with the previous study. Video-assisted thoracoscopic pleural biopsy was performed to obtain the definite diagnosis. Pathology confirmed the diagnosis as pleuropericardial involvement of Behçet's disease, and we treated the patient with oral steroid in the out-patient department. Pleuropericardial involvement of Behçet's disease may mimic TB pleurisy or pericarditis due to high adenosine deaminase (ADA) level in effusion analysis. Clinicians should keep in mind that Behçet's disease may manifest as pleural or pericardial effusion, and pathologic confirmation could be helpful for the definite diagnosis.Keywords: Pleural effusion; pericardial effusion; Behçet's syndrome; adenosine deaminase Submitted Jan 06, 2016. Accepted for publication May 11, 2016May 11, . doi: 10.21037/jtd.2016 View this article at: http://dx.doi.org/10.21037/jtd.2016.05.88 J Thorac Dis 2016;8(7):E547-E551 jtd.amegroups.com syndrome or pulmonary infarction. A few case reports have indicated pleural effusion due to primary vasculitis of the pleura (6). Cardiovascular involvement, including coronary artery disease, pericarditis, myocarditis, endocarditis, arrhythmia and valvular dysfunction, have been reported in <10% of patients with Behçet's disease (9-11). Pericardial involvement, a common cardiac manifestation with up to 40% cardiac involvement, may be associated with vasculitis of the pericardium or SVC thrombosis (6,10).The main pathologic characteristic of Behçet's disease is nonspecific vasculitis of small-to-large-sized vessels in both the systemic and pulmonary circulation, with perivascular infiltration of lymphocytes and mononuclear cells (12). Vasculitis mostly affects veins and accounts for approximately 85% of the vascular involvement (3). Endothelial cell swelling, fibrinoid necrosis and thrombus formation within the vessel lumen are common in inflammation foci (5,8).Anti-inflammatory and immunosuppressive drugs represent the mainstay treatments for Behçet's disease (7,8). However, the choice of treatment varies depending on the type of organ ...

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Behçet's disease and cardiac arrhythmia

Cited by 10 publications

References 9 publications

Aortic Regurgitation Caused by Behçet's Disease: Surgical Experience during an 11-Year Period

Aortic Regurgitation Caused by Behçet's Disease: Surgical Experience during an 11-Year Period

Cardiac and Great Vessel Involvement in “Behcet's Disease”

A 30-year-old female Behçet’s disease patient with recurrent pleural and pericardial effusion and elevated adenosine deaminase levels: case report

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