Behçet’s disease and comorbidity: internal case reports and literature review

Abstract

The aim of this study was to determine the clinical characteristics of two patients with malignancy related to Behçet's disease. We reviewed literary-reported cases of Behçet's disease related to myelodysplastic syndrome, neoplasm and leukemia. Our own observation included two cases of comorbid conditions of Behçet's disease. The first patient with Behçet's disease had been examined concurrent development of intestinal tumor. The second one was diagnosed to have chromic myeloleukemia. The malignant transformation of Behçet's disease patients, both solid and hematological, is rather rare. Further accumulation of relevant date and its analysis will allow to find out the relationship between malignant disease and chemotherapy in Behçet's disease.

Paraneoplasic Beh�et's Syndrome associated with Chronic Myeloid Leukemia

“…Behçet's syndrome has been reported in association with CML (1,3), some concurrent with or following treatment with interferon-α or hydroxyurea (2). Although the pathogenesis remains unclear, there is increasing awareness of its link to hematological malignancies and trisomy of the 8 th chromosome (1,3).…”

Myelodysplastic Syndrome and Autoimmune Disorders: Causal Relationship or Coincidence?

“…Two of the MDS patients with trisomy 8 and multiple intestinal ulcers were treated with granulocyte-colony stimulating factor (G-CSF), aggravating their symptoms, suggesting G-CSF should be used cautiously in this subgroup of MDS patients [45]. There is several case reports of BD associated with MDS [46][47][48][49]. In a case report of two patients with BD and MDS, it has been suggested that PET/CT may help diagnosis of both BD and MDS with high uptake by bone marrow in MDS patients and genital and gastrointestinal aphthous ulcers in BD patients [50].…”