Behcet's disease and pregnancy relationship study

Abstract

The effects of pregnancy on the course of Behçet's disease (BD), and vice versa, are unknown and little has been reported. We have studied three groups of women: (1) group A included 61 pregnancies in 23 women with BD, 25 pregnancies took place in 10 patients already diagnosed (group 1A) and 36 pregnancies occurred in 13 patients before disease diagnosis (group 2A); (2) group B included 30 females with 83 pregnancies affected by recurrent oral ulcers (ROU); (3) group C included 20 healthy women with 61 pregnancies. We investigated the effects of BD on pregnancy and fetal outcome, and the influence of gestation on the course of BD. A questionnaire was used in which specific information about each pregnancy, labour and puerperium was collected. We looked for medical confirmation in all cases where any pathology had been identified. No significant differences were found in the incidence of pregnancy complications between groups. The incidence of perinatal death was also similar and neither congenital abnormalities nor neonatal BD were observed. Only two patients observed a flare of the disease and in two cases the diagnosis of BD was made during the pregnancy. In our series, the outcome of pregnancy was generally good in BD patients, disease manifestations were not consistently worsened and fetal outcome was excellent. The first case of Budd-Chiari syndrome during the puerperium in a BD patient is reported.

Behçet's Disease and Pregnancy

“…Interestingly, of the 7 patients with obstetric complications, 5 had a history of venous thrombosis in BD prior to pregnancy (deep vein thrombosis [DVT], alone [n ϭ 2] or associated with dural sinus thrombosis [n ϭ 2]; pulmonary Comparison with series from the literature. Six series analyzing the interaction between BD and pregnancy have been published (10,(19)(20)(21)(22)26) and also were recently reviewed (29). By adding the data provided in the literature to those obtained in our study, a series of 279 pregnancies in 159 patients was available for analysis.…”

“…We added relevant articles that were not identified using this strategy but were present in the reference list of other studies. In total, 6 series with more than 2 patients were analyzed (10,(19)(20)(21)(22)26), along with one recent review of the literature (29).…”

“…Severe neurologic or vascular disease flares have also been reported (12)(13)(14), leading investigators to raise the question of whether the outcome of the pregnancy can be affected by BD (15)(16)(17)(18). For example, the rate of miscarriage was higher in some series (occurring in 20.7% of 77 pregnancies in patients with BD versus 6.6% of 288 pregnancies in control patients) (19), which contrasts with the results of other studies (20)(21)(22). Finally, treatment of BD during pregnancy is an important issue because of possible adverse effects that may also affect pregnancy outcome.…”

“…Finally, treatment of BD during pregnancy is an important issue because of possible adverse effects that may also affect pregnancy outcome. Nonetheless, observational studies of pregnant women with BD remain sparse and consist mainly of small series or case reports (8)(9)(10)(11)(12)(13)(19)(20)(21)(22)(23)(24)(25)(26)(27).…”

Systemic primary vasculitis and pregnancy

“…Преимущественно по-ражает молодых женщин во время детородного воз-раста [10]. Есть данные о беременности у пациенток с диагнозом ББ [32][33][34][35]. Заболевание имеет тенден-цию к улучшению во время беременности в ~ 63% случаев, тогда как рецидив заболевания зарегистри-рован в 28%.…”