Behçet's disease and risk of vascular events

Abstract

The cause of thrombosis or vascular events in Behçet's disease remains incompletely understood; several factors have been studied with conflicting results. Vasculitis is considered to underlie several clinical manifestations of Behçet's disease.

Behçet’s Disease: Pulmonary Aneurysm Resolution with Oral Therapy and HLA B72 Allele Association

“…1,2 Vascular involvement in BD is found in approximately 25% to 30% of the affected population. 4 Venous involvement is more common and may result in subcutaneous thrombophlebitis and deep venous thrombosis. Arterial involvement is less frequent, with aneurysms and occlusions of the abdominal aorta and carotid, femoral, popliteal, and coronary arteries.…”

“…Arterial involvement is less frequent, with aneurysms and occlusions of the abdominal aorta and carotid, femoral, popliteal, and coronary arteries. [4][5][6] This disease is the second highest cause of pulmonary artery aneurysm, with a high mortality rate. 4,[7][8][9] Many authors have recommended the use of immunosuppressants for the treatment of clinical manifestations of BD, including vascular complications.…”

“…[4][5][6] This disease is the second highest cause of pulmonary artery aneurysm, with a high mortality rate. 4,[7][8][9] Many authors have recommended the use of immunosuppressants for the treatment of clinical manifestations of BD, including vascular complications. [10][11][12][13][14] However, to date, no standardized therapeutic regimen has been developed for the treatment of complications, which can be determined depending on the organ(s) affected and the extent and severity of the involvement.…”

“…Some studies have shown the involvement of genetic factors in its pathogenesis. [1][2][3][4][18][19][20][21] The presence of the B51 allele as a genetic factor that predisposes individuals to BD has been reported by several authors. [18][19][20][21] Other studies have reported a positive correlation between the A2, A26, A30, A68, B15, B27, B57, B58, and B72 alleles and BD.…”

“…[18][19][20][21] Other studies have reported a positive correlation between the A2, A26, A30, A68, B15, B27, B57, B58, and B72 alleles and BD. 1,2,4,[18][19][20][21] The B51 allele was associated with mucous and skin manifestations, early-onset uveitis, and low gastrointestinal involvement. The B58 allele was associated with cutaneous manifestations.…”