Behçet’s disease as a systemic disease

Mat, M. Cem; Sevim, Ayşegül; Fresko, İzzet; Tüzün, Yalçın

doi:10.1016/j.clindermatol.2013.11.012

Cited by 59 publications

(48 citation statements)

References 51 publications

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“…BD also presents with heterogeneous clinical manifestations and can affect the cardiovascular, gastrointestinal, musculoskeletal, and central nervous systems [68]. The pathogenesis of BD is unclear; however, several lines of evidence indicate disease inflammation is associated with the activities of T cells and monocytes [69], the most prominent infiltrating cell types in the inflamed tissues of patients [52,70].…”

Section: Behçet's Diseasementioning

confidence: 99%

Epigenetics and Vasculitis: a Comprehensive Review

Renauer

Coit

Sawalha

2015

Clinic Rev Allerg Immunol

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Vasculitides represent a group of relatively rare systemic inflammatory diseases of the blood vessels. Despite recent progress in understanding the genetic basis and the underlying pathogenic mechanisms in vasculitis, the etiology and pathogenesis of vasculitis remain incompletely understood. Epigenetic dysregulation plays an important role in immune-mediated diseases, and the contribution of epigenetic aberrancies in vasculitis is increasingly being recognized. Histone modifications in the PR3 and MPO gene loci might be mechanistically involved in the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Similarly, other studies revealed important epigenetic contribution to other vasculitides, including Kawasaki disease and IgA vasculitis. More recently, genome-wide epigenomic studies have been performed in several vasculitides. A recent genome-wide DNA methylation study uncovered an important role for epigenetic remodeling of cytoskeleton-related genes in the pathogenesis of Behçet's disease and suggested that reversal of some of these DNA methylation changes associates with disease remission. Genome-wide DNA methylation profiling characterized the inflammatory response in temporal artery tissue from patients with giant cell arteritis and showed increased activation of calcineurin/nuclear factor of activated T cells (NFAT) signaling, prompting the suggestion that a specific calcineurin/NFAT inhibitor that is well tolerated and with the added beneficial anti-platelet activity, such as dipyridamole, might be of therapeutic potential in giant cell arteritis. While epigenetic studies in systemic vasculitis are still in their infancy, currently available data clearly indicate that investigating the epigenetic mechanisms underlying these diseases will help to better understand the pathogenesis of vasculitis and provide novel targets for the development of disease biomarkers and new therapies.

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Section: Behçet's Diseasementioning

confidence: 99%

Epigenetics and Vasculitis: a Comprehensive Review

Renauer

Coit

Sawalha

2015

Clinic Rev Allerg Immunol

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“…Abnormalities detected in neutrophils, endothelial cells, or both, have been suggested to be responsible for many of the clinical manifestations in BD. 25 Endocan is a proteoglycan which is secreted by vascular endothelial cells and which can be considered as a marker of endothelial activation. 26 To the best of our knowledge, until today, only one study has been conducted which has shown that plasma endocan increased in chronic kidney disease patients and influenced all-cause mortality together with cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 It most commonly affects Mediterranean and East Asian ethnic groups and generally starts between 20-35 years of age. 3,4 Although the etiopathogenesis of BD has not been completely identified, it is considered to be manifested due to intense inflammatory response triggered by an infectious agent in individuals having genetic predisposition. [5][6][7][8] Better understanding of the etiology and pathogenesis of BD at the cellular and biochemical levels is required in order to develop cure and prevention against the disease.…”

mentioning

confidence: 99%

Endocan Measurement for Active Behçet Disease

et al. 2017

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Objectives: This study aims to investigate the relationships between serum endocan, vascular endothelial growth factor (VEGF), and tumor necrosis factor-alpha (TNF-α) levels in active Behçet disease. Patients and methods: Forty patients with active Behçet disease (24 males, 16 females; mean age 37.6±8.7 years; range 20 to 50 years) and 40 healthy controls (22 males, 18 females; mean age 38.8±7.9 years; range 21 to 52 years) were included in this study. Both patient and control groups underwent a complete systemic and ophthalmic examination by the same specialist. Endocan, VEGF, and TNF-α levels were measured with an enzyme-linked immunosorbent assay kit in all subjects. Results: Serum endocan levels were 775.2±479.3 ng/mL and 275.8±145.8 ng/mL in the patient and control groups, respectively. VEGF levels were 1768.2±900.5 pg/mL and 980.2±135.3 pg/mL in the patient and control groups, respectively. TNF-α levels were 22.4±74.3 pg/mL-1 and 11.4±16.9 pg/mL-1 in the patient and control groups, respectively. There was a statistically significant difference between groups in terms of serum endocan, VEGF, and TNF-α levels. There was a significant positive correlation between serum endocan and VEGF levels in the patient group (r=0.630; p<0.001). Also, there was a significant positive correlation between serum endocan and TNF-α levels in the patient group (r=0.713; p<0.001). Conclusion: Serum endocan level may be a new marker in evaluation of both the prognosis and activity of Behçet disease.

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“…Most cases are sporadic although familial patterns have also been noted. Possible aetiology is autoimmune with HLA-B51 association, but the exact pathophysiology is not known (3) . More than 95% cases have orogential ulceration.…”

Section: Discussionmentioning

confidence: 99%

Unusual association of leptomeningitis, pachymeningitis, dural sinus thrombosis, posterior uveitis and pathergy in alady with Behcet’s disease

B¹

2018

jmscr

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Behçet’s disease as a systemic disease

Cited by 59 publications

References 51 publications

Epigenetics and Vasculitis: a Comprehensive Review

Epigenetics and Vasculitis: a Comprehensive Review

Endocan Measurement for Active Behçet Disease

Unusual association of leptomeningitis, pachymeningitis, dural sinus thrombosis, posterior uveitis and pathergy in alady with Behcet’s disease

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