Behçet's Disease

Kurokawa, Manae S.; Yoshikawa, Hideshi; Suzuki, Noboru

doi:10.1055/s-2004-836147

Cited by 32 publications

(37 citation statements)

References 54 publications

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“…Japanese Behçet's disease activity phase classiication was performed in 2003 [10]. In the active phase, presence of subcutaneous venous thrombosis, skin indings (i.e., erythema nodosum and genital ulcer), arthralgia, gastrointestinal ulcer, central nervous system lesions, vasculitis, or epididymitis, and serum CRP, cerebrospinal luid, colonoscopy in the clinical examination including ophthalmologic examination, and other clinical laboratory indings are evaluated.…”

Section: Behcet's Diseasementioning

confidence: 99%

“…(5) Inactive phase, which is deined as the stable phase (remission), means 0 activity index for more than 1 year [10].…”

Section: Behcet's Diseasementioning

confidence: 99%

“…HLA-B51 association and increased IL-17 response are thought to play a role in neutrophil activation [16]. Human mitochondrial heat shock protein (HSP) is highly homologous with microbial HSP and provokes proliferation of autologous T cells in Behçet's disease patients [10]. The HSP 60/65 plays an important role in Behçet's disease mucocutaneous lesions [10].…”

Section: Behcet's Diseasementioning

confidence: 99%

“…Human mitochondrial heat shock protein (HSP) is highly homologous with microbial HSP and provokes proliferation of autologous T cells in Behçet's disease patients [10]. The HSP 60/65 plays an important role in Behçet's disease mucocutaneous lesions [10]. The Serum IL-12 levels correlate with disease activity and higher levels of soluble TNFR-75 are presented in active Behçet's disease [17].…”

Section: Behcet's Diseasementioning

confidence: 99%

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Activity Criteria in Behçet’s Disease

Gül¹,

Nazik²,

Çiçek³

et al. 2017

Behcet's Disease

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Behçet's disease is a complex disease characterized by remission and activation periods of unknown duration. It has an unpredictable course. Behçet's disease shows a heterogeneous patern of organ involvement that occurs in recurrent episodes of acute inlammation throughout the course of the disease. Disease activity in Behçet's disease is diicult to deine because of its luctuating course, lack of laboratory tests relecting overall disease activity, absence of a standardized form to report the severity of Behcet's disease manifestations and also trying to develop new diagnostic criteria. This led to the development of standardized disease activity index. To be useful, a measurement of disease activity must be valid, reliable, and simple enough to use in routine clinical practice. We will try to explain what the situation is in terms of Behçet's disease activity index.

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Section: Behcet's Diseasementioning

confidence: 99%

“…(5) Inactive phase, which is deined as the stable phase (remission), means 0 activity index for more than 1 year [10].…”

Section: Behcet's Diseasementioning

confidence: 99%

Section: Behcet's Diseasementioning

confidence: 99%

Section: Behcet's Diseasementioning

confidence: 99%

See 2 more Smart Citations

Activity Criteria in Behçet’s Disease

Gül¹,

Nazik²,

Çiçek³

et al. 2017

Behcet's Disease

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“…The increased expression of both self and infective stress proteins and the extensive sequence homology and cross-reactivity between microbial HSPs (better known as groEL) and human HSPs led to the concept that HSPs might be involved in the etiopathogenesis of BD [63][64][65][66]. In addition to the HSP60, other HSPs (such as αB-crystallin and HSP70) have been suggested to play a role in the pathogenesis of BD [12,[67][68][69][70][71][72].…”

Section: Heat Shock Proteinsmentioning

confidence: 99%

Behcet’s disease: from heat shock proteins to infections

2014

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Background: Behcet's disease (BD) is a chronic, inflammatory multisystemic condition of unknown etiology. Although the cause of BD is not clear, it is believed to be the result of an autoimmune process triggered by an infectious or environmental agent (possibly local to a geographic region) in a genetically predisposed individual. Objective: To detail current knowledge of the role of microorganisms in the pathogenesis of BD and review the infectious etiology of this disease. Methods: The review based on publication in SCOPUS, Science direct, and PubMed. Results: A microbial infection has been implicated in the development of the disease to explain the strong inflammatory reactions observed, the activation of monocytes and macrophages, and the induction of proinflammatory cytokines and chemokines detected. Common factors linking some of the possible pathogenetic agents are extrinsically induced tissue stress or heat shock proteins, which react with host tissues and elicit significant T-helper type 1 cell responses. Conclusion: Based on collected data, we conclude that the microorganisms discussed seem to participate and, at least in part, act as triggers during the course of BD. By clarifying the microbial associations of BD and finding its etiology, particularly the causative antigens leading to BD, it would be easier to suggest more effective treatment and preventive strategies for this disease.

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