Behçet’s disease: Immunopathologic and therapeutic aspects

Meador, Robert; Ehrlich, George E.; Feldt, Joan M. Von

doi:10.1007/s11926-002-0023-z

Cited by 21 publications

(21 citation statements)

References 37 publications

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“…HLA-B51 has been strongly associated with Bechet’s syndrome and recurrent oral ulcers [31] [32] [33]. In addition, HLA-DR8 has been associated with treatment resistant Crohn’s disease.…”

Section: Discussionmentioning

confidence: 99%

Associations of HLA-A, -B and -DRB1 Types with Oral Diseases in Swiss Adults

et al. 2014

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Human leukocyte antigens (HLA) are crucial components of host defense against microbial challenge but the associations of HLA types with oral infectious diseases have not been studied in detail. This prospective cross-sectional study examined associations of HLA-A, -B and -DRB1 types with common oral diseases in a healthy Swiss adult population. 257 subjects (107 m, 150 f, mean age: 43.5 yr; range: 21–58 yr) with known HLA-A, -B and -DRB1 profiles and comprehensive medical records were included. A thorough anamnesis was followed by oral examinations including saliva flow measurements, the DMFT score for cariological status, complete periodontal status with plaque and bleeding indexes as well as assessment of mucosal alterations and temporomandibular dysfunction (TMD). Student’s t-test and Pearson chi-square test were utilized to compare the oral diseases between HLA positive and negative subjects. Bonferroni correction for multiple comparisons was used and PBonf<0.05 was considered statistically significant. HLA types -B15 (PBonf = 0.002), -B51 (PBonf = 0.02) and -DRB1*12 (PBonf = 0.02) were associated with less periodontal disease manifestations. HLA-A32 had a positive association with TMD dysfunction (PBonf = 0.012). No other statistically significant associations were observed. In conclusion, HLA types may contribute to the development of oral diseases in generally healthy Caucasian adults.

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Section: Discussionmentioning

confidence: 99%

Associations of HLA-A, -B and -DRB1 Types with Oral Diseases in Swiss Adults

et al. 2014

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“…The usual initial management is combined drug therapies, involving drugs such as colchicines, non-steroidal anti-inflammatory drug (NSAIDs), glucocorticosteroids, immunosuppressive, or cytotoxic medications. For mucocutaneous lesions, colchicines and NSAIDs are administered (17, 18). However, intestinal lesions are reportedly difficult to treat.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence and Clinical Characteristics of Esophageal Involvement in Patients with Behçet's Disease: A Single Center Experience in Korea

Cheon

Kim

et al. 2009

J Korean Med Sci

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While a significant amount of clinical information has been reported concerning intestinal involvement in Behçet's disease (BD), esophageal involvement in BD has not yet been studied extensively. The aim of this study was to evaluate the prevalence of esophageal involvement in BD and its clinical characteristics. We retrospectively reviewed the medical records of 842 patients diagnosed with BD at a single tertiary institution in Korea between January 1990 and June 2006. Of the 842 patients with BD, 129 patients (15.3%) experienced upper gastrointestinal symptoms that required inspection through esophagogastroduodenoscopy. Esophageal involvement was found in 6 (4.7%) of the 129 patients. The activity index of Behçet's disease did not differ among patients with or without esophageal involvement. All patients with esophageal involvement responded well to medical treatment and no one experienced serious complications. The results of our study demonstrate that the prevalence of esophageal involvement in BD is very low and that most patients with such involvement face few complications and respond well to medical treatment.

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“…Ocular lesions in Behçet's disease must be vigorously treated to prevent blindness, and therapy aims to reduce both the severity and frequency of ocular attacks. Despite therapeutic interventions, approximately 25% of all patients with ocular manifestations of Behçet's disease will become blind 54 . Systemic corticosteroids continue to be used extensively, and may be administered as intravenous pulse therapy.…”

Section: Treatment Of Behçet's Diseasementioning

confidence: 99%

Oral ulceration – aetiopathogenesis, clinical diagnosis and management in the gastrointestinal clinic

Field

Allan

2003

Aliment Pharmacol Ther

152

124

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Summary Oral ulceration is a common complaint of patients attending out‐patient clinics. The aim of this review is to provide the gastroenterologist with a differential diagnosis of oral ulceration, and a practical guide for the management of recurrent aphthous stomatitis, including topical and systemic therapy. The association of recurrent aphthous stomatitis with Behçet's disease and other systemic disorders, including coeliac disease, is discussed. Recent evidence concerning the immunopathogenesis of Behçet's disease is reviewed, including renewed interest in the role of Streptococcus sanguis and possible infectious triggering of an inappropriate immunoinflammatory response, resulting in tissue damage. The efficacy and limitations of conventional treatment for this mutisystem disorder are outlined together with the potential role of novel biological agents, such as anti‐tumour necrosis factor‐α therapy. Oral ulceration, as a manifestation of inflammatory bowel disease and a complication of drug therapy, is described. Guidance is given concerning indications for referral of patients with oral ulceration to an oral physician/surgeon for further investigations, including biopsy if appropriate.

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Behçet’s disease: Immunopathologic and therapeutic aspects

Cited by 21 publications

References 37 publications

Associations of HLA-A, -B and -DRB1 Types with Oral Diseases in Swiss Adults

Associations of HLA-A, -B and -DRB1 Types with Oral Diseases in Swiss Adults

The Prevalence and Clinical Characteristics of Esophageal Involvement in Patients with Behçet's Disease: A Single Center Experience in Korea

Oral ulceration – aetiopathogenesis, clinical diagnosis and management in the gastrointestinal clinic

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