Behcet's disease in acquired immune deficiency syndrome

Siddiqui, Beenish; Fernandes, Denise C.; Chaucer, Benjamin; Chevenon, Marie; Nandi, Minesh; Saverimuttu, Jessie; Nfonoyim, Jay

doi:10.1016/j.idcr.2015.11.003

Cited by 5 publications

(4 citation statements)

References 8 publications

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“…Behcet's Disease The rare cases occurred in the setting of an acute HIV infection characterized by a high viral load, and these symptoms decreased following initiation of effective antiretroviral therapy and a rapid decreased of virologic load. Researchers have postulated that induction of Behcet's disease in HIV-associated cases might be a direct effect of viral replication or through HIV induction of autoimmune mechanisms or immune dysregulation [38,39].…”

Section: Other Vasculitismentioning

confidence: 99%

Vasculitides in HIV Infection

Vega¹,

Espinoza

2020

Curr Rheumatol Rep

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Purpose of Review To review the spectrum of vasculitides in HIV-infected patients and to identify the clinical features that characterize vasculitis in sero-positive HIV. Recent Findings Epidemiological studies conducted in the post-HAART era described the rarity of vasculitis in the setting of HIV-infected patients. A study identified histopathological features such as leukocytoclastic vasculitis of the vasa vasorum and adventitial inflammation in the large artery pathology of HIV-positive patients compared with HIV-negative patients with critical lower limb ischemia. A recent retrospective cohort study reported that HIV-positive patients with LVV developed more vascular complications, responded less to antiretroviral therapy, and had worse outcome than HIV-negative patients with LVV. Summary Vasculitides continue to be a rare disease in patients with HIV. The spectrum of vasculitis ranges from life-threatening conditions to relatively mild skin conditions. Recognizing vasculitis in the setting of HIV-positive patients is important because sometimes it require immunosuppressive treatment.

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Section: Other Vasculitismentioning

confidence: 99%

Vasculitides in HIV Infection

Vega¹,

Espinoza

2020

Curr Rheumatol Rep

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“…Several cases have been reported in relation to HIV infection. 7,[61][62][63][64][65][66][67][68][69] In general, patients respond to HAART alone 63,64 or in conjunction with drugs commonly used in the treatment of BD. A patient reported by Siddiqui et al had recurrent symptoms under HAART and intestinal bleeding that required a colectomy.…”

Section: Adamantiades-behçet's Diseasementioning

confidence: 99%

“…The patient eventually responded to colchicine, although non-compliance with antiretroviral therapy is mentioned. 68 In another case, a patient had a multisystem disease that responded partially to HAART and hydroxychrolochine plus colchicine, but later developed IgA nephropathy requiring immunosuppressive therapy. 65 BD was found in 15% of a cohort of 98 Chinese HIV patients, mostly not under HAART.…”

Section: Adamantiades-behçet's Diseasementioning

confidence: 99%

Diffuse connective tissue disorders in HIV-infected patients

Christoforidou

Galanopoulos

2018

MJR

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Background: Human immunodeficiency virus (HIV) infection has been associated with various autoimmune disorders. Aim: To review the spectrum of diffuse connective tissue disorders (dCTD) in HIV-infected patients, in the context of highly active anti-retroviral therapy. Methods: Electronic search of the literature was performed using the terms HIV, AIDS, autoimmune, rheumatic/rheumatological, immune reconstitution inflammatory syndrome, Systemic Lupus Erythematosus, Diffuse Infiltrative Lymphocytosis Syndrome, Sjogren's syndrome, vasculitis, Behçet's disease, cryoglobulins, Henoch-Schönlein purpura, and antiphospholipid syndrome. Results: We reviewed the clinical manifestations, natural history and treatment of dCTDs, since the implementation of Highly Active Anti-Retroviral Therapy (HAART), and the emergence of new pathogenic mechanisms, such as the immune reconstitution inflammatory syndrome. Conclusions: Caution in differentiating clinical and laboratory findings of dCTDs from non-specific manifestations of acute and chronic HIV infection is warranted due to the common presentation. Patients with chronic infection and access to HAART have a normal life expectancy and dCTDs, although rare, must be correctly addressed. HAART alone or combined with immunosuppressive therapy result in favourable outcomes.

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“…Also, PLHIV may have low CD4 + T-cell count, and unsuppressed viral load with higher risk for severe COVID-19 [ 17 ]. They have higher frequency of autoimmunity and immune dysregulation [ 16 ] as well more medical comorbidities that may increase their risk for oral ulcers [ 18 – 23 ].…”

Section: Introductionmentioning

confidence: 99%

Risk indicators for oral ulcers among people living with HIV during the first wave of the pandemic: a cross sectional study

Folayan,

Zuñiga,

Virtanen

et al. 2023

BMC Oral Health

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Background Little is currently known about HIV-related parameters that may increase the risk for oral ulcers during the COVID-19 pandemic. This study aimed to overcome this gap in research by assessing the associations between HIV viral load, antiretroviral adherence profile, co-morbidity status, SARS-CoV-2 infection and oral ulcers among people living with HIV (PLHIV). Methods This was a secondary analysis of data generated from 21,206 to 18 years and above, recruited from 152 countries through an online survey between July and December 2020. Data were extracted for 874 people who reported living with HIV. The dependent variable was reporting having oral ulcer. The independent variables were the viral load, adherence to antiretroviral treatment and a history of SARS-CoV-2 infection. The confounding variables were age at last birthday and sex at birth. A multivariable logistic regression analysis was conducted to determine the associations between the dependent and independent variables after adjusting for the confounding variables. Results Of the 874 participants, 99 (11.3%) reported having oral ulcers during the first wave of the COVID-19 pandemic. The odds of PLHIV having oral ulcers during the first wave of the COVID-19 pandemic was significantly higher for people who did not know their viral load than those who had undetectable viral load (AOR: 2.036; 95% CI: 1.204–3.443; p = 0.008); and people who did not adhere to the use of antiretroviral treatment than those who adhered (AOR: 4.113; 95% CI: 2.567–6.589; p < 0.001). Also, PLHIV who had SARS-CoV-2 infection had significantly higher odds of having oral ulcers than those who did not have the infection (AOR: 14.556; 95% CI: 4.500-47.078; p < 0.001). PLHIV who had co-morbidities had non-significantly higher odds of having oral ulcers than those without co-morbidities (AOR: 1.170; 95% CI: 0.656–2.085; p = 0.595). Conclusion Oral ulcers may be an indicator of poor adherence to antiretroviral therapy and unsuppressed viral load among PLHIV. It may also be an indicator of SARS-CoV-2 infection and a signal to take prompt and critical care of affected individuals because of the risk for severe COVID-19 for these individuals.

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Behcet's disease in acquired immune deficiency syndrome

Cited by 5 publications

References 8 publications

Vasculitides in HIV Infection

Vasculitides in HIV Infection

Diffuse connective tissue disorders in HIV-infected patients

Risk indicators for oral ulcers among people living with HIV during the first wave of the pandemic: a cross sectional study

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