Behçet’s Disease in Saudi Arabia: Clinical and Demographic Characteristics

Alharthy, Fayez; Almaqati, Ahmed S; Alsulami, Sarah; Ahmad, Akram

doi:10.7759/cureus.34867

Cited by 3 publications

(5 citation statements)

References 19 publications

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“…In the current research, there were 93.3% males and 6.7% females. These results are consistent with a cohort study in Saudi Arabia where patients were classified as 73.6% males and 26.4% females [11] . Arab populations tend to be predominately male, whereas those of Korea, China, the United States, and even certain northern European nations tend to be predominately female [8] .…”

Section: Discussionsupporting

confidence: 92%

“…This research revealed that 96.7% of studied cases received DMARDS (63.3% on Azathioprine, 26.7% on Cyclosporine, 13.3% on Methotrexate, 3.3% on Leflunomide, 3.3% on cyclophosphamide), 6.7% on adalimumab, 30.0% on infliximab, 90% on steroid, 20% on colchicine and 3.3% on warfarin). While Alharthy et al [11] revealed that patients who received prednisolone were 72.5%, azathioprine was 36.3%, mycophenolate mofetil was 0.75%, cyclosporine was 0.03% and colchicine was 95.6%.…”

Section: Discussionmentioning

confidence: 99%

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Serum Amyloid-A in Behçet’s Disease: Relation to Clinical Manifestations and Disease Activity

2024

The Egyptian Journal of Hospital Medicine

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Background: Behcet's disease (BD) is an autoimmune systemic vasculitis with an unknown origin. Recent discoveries have proven the essential role of Serum Amyloid A (SAA) in the pathophysiology of inflammatory rheumatic illnesses, including its involvement in the activation of the inflammasome cascade and the recruitment of interleukin 17-producing T helper cells. Aim of the work:This study aimed to measure the level of SAA in Behçet's disease and to examine the relation of SAA levels with disease activity and different organ involvement. Patients and Methods: This case-control research was done on 30 Behcets' cases which were subjected to history taking, full clinical examination, and assessment of disease activity by Behcet Disease Current Activity Form (BDCAF). Investigation in the form of CBC, ESR, CRP, and SAA were assessed. Results: Serum amyloid-A level was significantly greater in BD cases when contrasted to controls (P<0.001). Higher SAA was significantly related to the existence of oral ulcers, genital ulcers (P=0.041), eye involvement (P=0.005), and musculoskeletal manifestations (P=0.049). Skin manifestations, neurologic and large vessel involvements were not associated with SAA levels (P=0.948, P=0.077, and P=0.198 respectively). Lower SAA was significantly associated with those who received biologic therapy (P=0.045). Serum amyloid-A levels revealed significant positive relationships with disease activity (P<0.05) and higher SAA was considered a risk predictor for BD susceptibility (P=0.002), OR 1.156. Conclusion: Serum amyloid-A would be a predictor for BD susceptibility and activity. SAA levels are associated with ocular manifestations and could be a predictor of eye involvement.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Serum Amyloid-A in Behçet’s Disease: Relation to Clinical Manifestations and Disease Activity

2024

The Egyptian Journal of Hospital Medicine

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“…Behçet's symdrome predominantly occurs in populations with historical roots along the Silk Road [4]. Until now, differences in clinical manifestations between males and females with BS have been examined across different geographical regions, such as the Middle East, East Asia, and Europe [6,[11][12][13][14][15]17]. In the Middle East region, one notable multicenter retrospective investigation in Egypt reported a higher prevalence of acne/pseudofolliculitis and vascular involvement in males.…”

Section: Discussionmentioning

confidence: 99%

“…A comprehensive study involving BS patients from diverse populations revealed significant gender-specific variations, with males exhibiting a notably higher genetic risk score, especially in the human leukocyte antigen (HLA) class I region, compared to female patients [10]. Additionally, observational studies in different geographic regions have underscored gender-associated clinical differences in BS [6,[11][12][13][14][15]. In contrast, some studies from different geographic regions did not find any gender differences in BS [7].…”

Section: Introductionmentioning

confidence: 99%

Gender disparities in Behçet’s syndrome: identifying distinct phenotypes through cluster analysis

Kılıç,

Körüklü,

Kumcu

et al. 2024

Immunol Res

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Behçet’s syndrome (BS) is a complex, multi-systemic disorder with a global occurrence, notably concentrated along the Silk Road. This study aimed to investigate gender-specific expressions and clinical phenotypes in BS patients within the Eastern Black Sea Region of Turkey. A total of 290 BS patients were retrospectively analyzed between January 2013 and December 2023. Demographic characteristics, clinical manifestations, medical treatment, and pathergy test results were obtained from a review of medical records. The mean age was 45.79 ± 13.05, with a male-to-female ratio of 48.6:51.4. Male patients had higher papulopustular lesions (p < 0.001) and ocular involvement (p = 0.036), while females showed more frequent genital ulcers (p = 0.032). Medication usage showed gender-based variations, notably higher corticosteroid, azathioprine, and tumor necrosis factor-alpha inhibitor (TNFi) use in males (p < 0.001). Cluster analysis revealed five distinct clusters, each with unique features and gender predominance. Cardiovascular type, ocular type, and skin type predominantly featured male patients, while joint involvement type and neurologic and mucosal involvement type were more prevalent among female patients with BS. This research contributes valuable insights into the gender-related clinical variations of BS within a specific geographic region, fostering a more comprehensive understanding of this challenging syndrome. The identification of distinct clinical phenotypes facilitates the development of tailored treatment strategies, potentially leading to improved outcomes for patients with BS.

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“…A p-value < 0.05 was considered statistically significant. For our analyses, we used IBM SPSS 29.0 statistical software 35 , which was developed by IBM SPSS Japan, Inc.…”

Section: Discussionmentioning

confidence: 99%

Sedentary behaviour may cause differences in physical outcomes and activities of daily living in older cardiovascular disease patients participating in phase I cardiac rehabilitation

Izawa,

Ishihara,

Kanejima

et al. 2024

Sci Rep

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This study aimed to investigate the rate of sedentary behaviour and differences in physical outcomes and activities of daily living (ADL) based on sedentary behaviour time of hospitalized older cardiovascular disease patients undergoing phase I cardiac rehabilitation. Older cardiovascular disease patients were enrolled from October 2020 to September 2023 and were divided into the high sedentary behaviour group (≥ 480 min/day) and low sedentary behaviour group (< 480 min/day). Patients’ clinical characteristics, usual gait speed, and Five Times Sit to Stand Test time were compared as indices of physical outcomes. Motor, cognitive, and total Functional Independence Measure (FIM) scores were used as indices of ADL and compared between groups using analysis of covariance. Final analysis included 402 patients (mean age: 76.7 years, female: 35.3%). The high sedentary behaviour group included 48.5% of the study patients. After adjustment for baseline characteristics, gait speed (0.80 ± 0.27 vs. 0.96 ± 0.23 m/s, p < 0.001) was lower and FTSST time (11.31 ± 4.19 vs. 9.39 ± 3.11 s, p < 0.001) was higher in the high sedentary behaviour group versus low sedentary behaviour group. Motor (85.82 ± 8.82 vs. 88.09 ± 5.04 points, p < 0.001), cognitive (33.32 ± 2.93 vs. 34.04 ± 2.24 points, p < 0.001), and total FIM scores (119.13 ± 10.66 vs. 122.02 ± 6.30 points, p < 0.001) were significantly lower in the high sedentary behaviour group versus low sedentary behaviour group after adjustment. In older cardiovascular disease patients in phase I cardiac rehabilitation, sedentary behaviour time might influence physical outcomes and ADL at discharge. It is thus important to consider the amount of sedentary behaviour time spent by these patients during daily life while hospitalized.

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Behçet’s Disease in Saudi Arabia: Clinical and Demographic Characteristics

Cited by 3 publications

References 19 publications

Serum Amyloid-A in Behçet’s Disease: Relation to Clinical Manifestations and Disease Activity

Serum Amyloid-A in Behçet’s Disease: Relation to Clinical Manifestations and Disease Activity

Gender disparities in Behçet’s syndrome: identifying distinct phenotypes through cluster analysis

Sedentary behaviour may cause differences in physical outcomes and activities of daily living in older cardiovascular disease patients participating in phase I cardiac rehabilitation

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