Behçet’s syndrome: recent advances to aid diagnosis

Akbaba, Tayfun Hilmi; Ekici, Mustafa; Çolpak, Ayşe İlksen; Brown, Kelly L.; Karadağ, Ömer; Balci-Peynircioglu, Banu

doi:10.1007/s10238-023-01226-7

Cited by 3 publications

(2 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Behçet disease is a complex and rare disorder characterized by a unique combination of autoimmune and autoinflammatory features. This condition involves abnormal inflammation of blood vessels, leading to a range of symptoms affecting various parts of the body [ 80 ]. As both an autoinflammatory and autoimmune disease, Behçet poses challenges in understanding its precise mechanisms.…”

Section: Dysregulation Of Mirna Expression In Human Diseasementioning

confidence: 99%

Exploring regulatory mechanisms on miRNAs and their implications in inflammation-related diseases

Nalbant,

Akkaya-Ulum

2024

Clin Exp Med

View full text Add to dashboard Cite

This comprehensive exploration delves into the pivotal role of microRNAs (miRNAs) within the intricate tapestry of cellular regulation. As potent orchestrators of gene expression, miRNAs exhibit diverse functions in cellular processes, extending their influence from the nucleus to the cytoplasm. The complex journey of miRNA biogenesis, involving transcription, processing, and integration into the RNA-induced silencing complex, showcases their versatility. In the cytoplasm, mature miRNAs finely tune cellular functions by modulating target mRNA expression, while their reach extends into the nucleus, influencing transcriptional regulation and epigenetic modifications. Dysregulation of miRNAs becomes apparent in various pathologies, such as cancer, autoimmune diseases, and inflammatory conditions. The adaptability of miRNAs to environmental signals, interactions with transcription factors, and involvement in intricate regulatory networks underscore their significance. DNA methylation and histone modifications adds depth to understanding the dynamic regulation of miRNAs. Mechanisms like competition with RNA-binding proteins, sponging, and the control of miRNA levels through degradation and editing contribute to this complex regulation process. In this review, we mainly focus on how dysregulation of miRNA expression can be related with skin-related autoimmune and autoinflammatory diseases, arthritis, cardiovascular diseases, inflammatory bowel disease, autoimmune and autoinflammatory diseases, and neurodegenerative disorders. We also emphasize the multifaceted roles of miRNAs, urging continued research to unravel their complexities. The mechanisms governing miRNA functions promise advancements in therapeutic interventions and enhanced insights into cellular dynamics in health and disease.

show abstract

Section: Dysregulation Of Mirna Expression In Human Diseasementioning

confidence: 99%

Exploring regulatory mechanisms on miRNAs and their implications in inflammation-related diseases

Nalbant,

Akkaya-Ulum

2024

Clin Exp Med

View full text Add to dashboard Cite

show abstract

“…BD can involve multiple organs or systems, including recurrent oral and genital ulcerations, intestinal involvement, arthritis, ocular manifestations, skin lesions, as well as vascular and neural involvement[ 1 , 9 ]. The distribution of BD in the population varies widely (0.64-420/100000)[ 10 ], with a predilection for countries along the "ancient Silk Road" route, stretching from the Mediterranean, Middle East, to East Asia[ 11 ]. Prevalence is lower in Nordic and North American regions[ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Intestinal Behçet's disease: A review of clinical diagnosis and treatment

Liu,

Gao,

Yang

et al. 2024

World J Gastrointest Surg

View full text Add to dashboard Cite

Behçet's disease (BD) is a chronic inflammatory disorder prone to frequent recurrences, with a high predilection for intestinal involvement. However, the efficacy and long-term effects of surgical treatment for intestinal BD are unknown. In the current issue of World J Gastrointest Surg , Park et al conducted a retrospective analysis of 31 patients with intestinal BD who received surgical treatment. They found that elevated C-reactive protein levels and emergency surgery were poor prognostic factors for postoperative recurrence, emphasizing the adverse impact of severe inflammation on the prognosis of patients with intestinal BD. This work has clinical significance for evaluating the postoperative condition of intestinal BD. The editorial attempts to summarize the clinical diagnosis and treatment of intestinal BD, focusing on the impact of adverse factors on surgical outcomes. We hope this review will facilitate more precise postoperative management of patients with intestinal BD by clinicians.

show abstract

The Potential Role of Butyrate in the Pathogenesis and Treatment of Autoimmune Rheumatic Diseases

Coccia,

Bonomi,

Lo Cricchio

et al. 2024

Biomedicines

View full text Add to dashboard Cite

The gut microbiota is a complex ecosystem of microorganisms residing in the human gastrointestinal tract, playing a crucial role in various biological processes and overall health maintenance. Dysbiosis, an imbalance in the composition and function of the gut microbiota, is linked to systemic autoimmune diseases (SAD). Short-chain fatty acids (SCFAs), especially butyrate, produced by the gut microbiota through the fermentation of dietary fibers, play a significant role in immunomodulation and maintaining intestinal homeostasis. Butyrate is essential for colonocyte energy, anti-inflammatory responses, and maintaining intestinal barrier integrity. Studies show reduced butyrate-producing bacteria in SAD patients, suggesting that increasing butyrate levels could have therapeutic benefits. Butyrate’s anti-inflammatory effects and its potential therapeutic role have been studied in rheumatoid arthritis, Sjogren’s syndrome, systemic lupus erythematosus, systemic sclerosis, and Behçet’s disease. Despite promising in vitro and animal model results, human studies are limited, and the optimal strategies for modulating dysbiosis in SADs remain elusive. This review explores the current evidence on the immunoregulatory role of butyrate and its potential therapeutic effects in SAD.

show abstract

Behçet’s syndrome: recent advances to aid diagnosis

Cited by 3 publications

References 89 publications

Exploring regulatory mechanisms on miRNAs and their implications in inflammation-related diseases

Exploring regulatory mechanisms on miRNAs and their implications in inflammation-related diseases

Intestinal Behçet's disease: A review of clinical diagnosis and treatment

The Potential Role of Butyrate in the Pathogenesis and Treatment of Autoimmune Rheumatic Diseases

Contact Info

Product

Resources

About