This study maps the rural household vulnerability to flood-induced health risks in flood-affected Khyber Pakhtunkhwa (KPK), Pakistan, focusing on the devastating 2022 flood. Using data from 600 households in the severely impacted districts of Khyber Pakhtunkhwa province (including Charsadda and Nowshera), this research examines the influence of demographic, socioeconomic, and infrastructural factors on household vulnerability. This study assesses household vulnerability to flooding and health issues using logistic regression. The current study findings revealed that female-headed households, those with younger heads, and families with lower educational levels are particularly vulnerable. Income disparities significantly shape coping capacity, with wealthier households more likely to adopt effective risk-mitigation strategies. Proximity to functioning healthcare facilities emerged as a crucial factor in reducing vulnerability, as these households faced fewer health hazards. Conversely, households in areas where health and water infrastructure were damaged experienced higher risks of disease outbreaks, including cholera and malaria, due to water contamination and inadequate sanitation. This study highlights the urgent need for resilient infrastructure, strengthened public health systems, improved health education, and enhanced water and sanitation services to mitigate flood-induced health risks. Policymakers are urged to sustainable development practices by adopting gender-sensitive disaster management strategies, prioritizing educational initiatives, and fostering community support networks to enhance resilience to future flood events in KPK.