Being born large for gestational age is associated with earlier pubertal take‐off and longer growth duration: a longitudinal study

Giovanni, Ilaria Di; Marcovecchio, M Loredana; Giorgis, Tommaso de; Chiarelli, Francesco; Mohn, Angelika

doi:10.1111/apa.13633

Cited by 11 publications

(11 citation statements)

References 31 publications

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“…The initial search netted 18 968 titles, with 38 full texts included for review (Figure ) . These amounted to a total of 22 721 individuals, with 60% female representation.…”

Section: Resultsmentioning

confidence: 99%

The tempo of puberty and its relationship to adolescent health and well‐being: A systematic review

et al. 2019

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Puberty is a major developmental period characterised by the height growth spurt, appearance of secondary sex characteristics, body composition alterations and increasing circulating hormone levels. 1,2 Variability exists in how early (timing of onset) and rapidly (tempo of puberty) individuals commence and progress through these changes.Such variability is known to have immediate and lifelong impacts on health and well-being which, in turn, has clear implications to practice in terms of identifying and delivering timely supportive therapies to those exhibiting "at risk" developmental trajectories.The clinical and hormonal markers of pubertal onset, together with the age range at which onset occurs, are well recognised. The first signs of puberty are measured by the attainment of Tanner stage (TS) 2 for breast (B2) or genital (G2) development, or a rise in gonadal hormones above the childhood range. 3 The typical age of onset ranges from 8 to Cheng and Harris contributed equally to this work.Abbreviations: ATO, age at height take-off; APHV, age at peak height velocity; B2/5, Tanner breast development stage 2/5; BMI, body mass index; G2/5, Tanner genital development stage 2/5; TS Tanner stage; zBMI, age-and sex-adjusted body mass index z-score Abstract Aim: Emerging evidence suggests that pubertal tempo, that is rate of passage through puberty, has relevance to adolescent mood and behaviour. However, its wider health and developmental significance remain unclear. This systematic review sought to clarify the relationship of pubertal tempo to indicators of health and development, and to document tempo definitions and pubertal durations reported in the literature. Methods: Eight electronic databases were searched from earliest record to July 2018. Study eligibility: healthy participants; age 8-21 years; ≥2 longitudinal measures of puberty; analysis of tempo against a health or developmental indicator. Results: Thirty-eight studies met eligibility, and these reported on diverse tempo definitions and seven health-and development-related domains. Data sets with varying tempo definitions converged on an association of rapid pubertal progression to: (a) higher adiposity during childhood and adolescence in both sexes; and (b) lower psychosocial well-being in adolescent males. Later thelarche unanimously predicted faster progression to menarche in females, but this compensation was largely undetected when alternate definitions of pubertal timing and/or tempo were used. Duration of puberty ranged from 2.5-4.1 years. Conclusion: Pubertal tempo may be clinically relevant when considering trajectories of adiposity and psychosocial well-being among adolescents, especially males. Consensus on the definition of tempo would facilitate between-study comparisons. K E Y W O R D S adiposity, adolescence, behaviour problems, depression, pubertal pattern | 901 CHENG Et al. S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Cheng HL, Ha...

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“…The initial search netted 18 968 titles, with 38 full texts included for review (Figure ) . These amounted to a total of 22 721 individuals, with 60% female representation.…”

Section: Resultsmentioning

confidence: 99%

The tempo of puberty and its relationship to adolescent health and well‐being: A systematic review

et al. 2019

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“…A recent paper by Di Giovanni et al has shown that babies being large for GA (high birth weight) have earlier onset of pubertal growth, and a previous study by our research group found a linear negative correlation between BMI in childhood and onset of pubertal growth. 23,36 Higher weight at birth and higher BMI in the 1990 cohort might be related to earlier pubertal growth seen for girls in the later-born cohort, analogous to these two studies. Compared with the former Swedish growth reference of individuals born in 1956, the 1974 cohort showed earlier mid-pubertal growth.…”

Section: Discussionmentioning

confidence: 57%

Estimating secular changes in longitudinal growth patterns underlying adult height with the QEPS model: the Grow Up Gothenburg cohorts

Holmgren

Niklasson

Nierop³

et al. 2018

Pediatr Res

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“…Our finding of inverse associations of LGA with adolescent metabolic traits are consistent with a study of 18,288 adolescents and adults with the same metabolomics platform as our study (52) which showed a higher mean birth weight across the distribution was associated with healthier lipid profile, including lower triglycerides, and other lipids that we see inverse associations of LGA with in our study. This may reflect an interplay with offspring adiposity and puberty whereby LGA offspring have higher prepubertal body fat compared to AGA (53) with this leading to earlier puberty for LGA (54, 55) which in turn might influence metabolic traits (56). This may also explain our finding that the association between LGA and healthier metabolic profile was weakened or even reversed by early midlife (since all AGA offspring should have already completed puberty).…”

Section: Discussionmentioning

confidence: 99%

Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study

Elhakeem

Ronkainen

Mansell

et al. 2022

Preprint

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Background Common pregnancy and perinatal complications are associated with offspring cardiometabolic risk factors. These complications may influence multiple metabolic traits in offspring and these associations might differ with offspring age. Methods: We used data from eight population-based cohort studies to examine and compare associations of pre-eclampsia (PE), gestational hypertension (GH), gestational diabetes (GD), preterm birth (PTB), small (SGA) and large (LGA) for gestational age (vs. appropriate size for gestational age (AGA)) with up to 167 plasma/serum-based nuclear magnetic resonance-derived metabolic traits encompassing lipids, lipoproteins, fatty acids, amino acids, ketones, glycerides/phospholipids, glycolysis, fluid balance, and inflammation. Confounder-adjusted regression models were used to examine associations (adjusted for maternal education, parity age at pregnancy, ethnicity, pre/early pregnancy body mass index and smoking, and offspring sex and age at metabolic trait assessment), and results were combined using meta-analysis by five age categories representing different periods of the offspring life course: neonates (cord blood), infancy (mean ages: 1.1-1.6y), childhood (4.2-7.5y); adolescence (12.0-16.0y), and adulthood (22.0-67.8y). Results: Offspring numbers for each age category/analysis varied from 8,925 adults (441 PTB) to 1,181 infants (135 GD); 48.4% to 60.0% were females. Pregnancy complications (PE, GH, GD) were each associated with up to three metabolic traits in neonates (P≤0.001) with some limited evidence of persistence to older ages. PTB and SGA were associated with 32 and 12 metabolic traits in neonates respectively, which included an adjusted standardised mean difference of -0.89 standard deviation (SD) units for albumin with PTB (95%CI: -1.10 to -0.69, P=1.3x10-17) and -0.41SD for total lipids in medium HDL with SGA (95%CI: -0.56 to -0.25, P=2.6x10-7), with limited evidence of persistence to older ages. LGA was inversely associated with 19 metabolic traits including lower levels of cholesterol, lipoproteins, fatty acids, and amino acids, with associations emerging in adolescence, (e.g., -0.11SD total fatty acids, 95%CI: -0.18 to -0.05, P=0.0009), and attenuating with older age across adulthood. Conclusions: These reassuring findings suggest little evidence of wide-spread and long-term impact of common pregnancy and perinatal complications on offspring metabolic traits, with most associations only observed for new-borns rather than older ages, and for perinatal rather than pregnancy complications.

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Being born large for gestational age is associated with earlier pubertal take‐off and longer growth duration: a longitudinal study

Cited by 11 publications

References 31 publications

The tempo of puberty and its relationship to adolescent health and well‐being: A systematic review

The tempo of puberty and its relationship to adolescent health and well‐being: A systematic review

Estimating secular changes in longitudinal growth patterns underlying adult height with the QEPS model: the Grow Up Gothenburg cohorts

Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study

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