Objective: This study aimed to investigate Islamic Self-care in Iranian medical students. Methods: In this descriptive study that was done in 2015, students of the Mazandaran University of Medical Sciences (faculties of health, paramedical, pharmacy, medicine and dentistry) were selected through classified random sampling. Study sample was calculated 269 from 900 students based on Krejcie and Morgan's table. Data gathering was done using demographic and a standardized questionnaire about Islamic Self-care. Results: In this study, 269 students were entered to study. The mean (SD) score of Stipulation, Meditation, Calculation and Expostulation of students were 9.82 (2.35), 10.04 (2.85), 8.74 (2.65) and 7.64 (2.48) respectively. Results shows that correlation between all the components of the Self-care are positive and significant (p < .001). Conclusions: It is worthy that further study will be aimed to investigate ways to strengthen it, as well as explaining the benefits of Islamic Self-care among students with the theoretical and practical examples.