Beitr�ge zur Kenntniss der Bildung der Harns�ure und der Xanthinbasen, sowie der Entstehung der Leucocytosen im S�ugethierorganismus

Horbaczewski, J.

doi:10.1007/bf01538598

Cited by 27 publications

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“…He also left a bequest of wrangles about hydrolytic and oxidative enzymes that are still not fully resolved. He showed also that the ingestion of nucleic acid leads to increased uric acid excretion but attributed it to an alimentary leukocytosis (HORBACZEWSKI, 1891). This interpretation was prompted by his previous true observation that patients with leukemia excrete excessive amounts of uric acid, i.e., leukocytes are the sole source.…”

Section: A Introductionmentioning

confidence: 96%

Uric Acid: Chemistry and Synthesis

Hitchings¹

1978

Uric Acid

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Section: A Introductionmentioning

confidence: 96%

Uric Acid: Chemistry and Synthesis

Hitchings¹

1978

Uric Acid

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“…Xanthine oxidase (XO) [1][2][3] plays a key physiological role in purine metabolism resulting in uric acid as the end product. Apart from two [2Fe-2S] centers and one FAD cofactor, XO contains a delicate mononuclear {Mo VI OS} active site which hydrolyses readily to generate the corresponding inactive {Mo VI O 2 } form.…”

Section: Introductionmentioning

confidence: 99%

Modelling the reduced xanthine oxidase in active sulfo and inactive desulfo forms

Mitra

Sarkar

2013

Dalton Trans.

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Synthesis of two complexes, [NBu(n)(4)][Mo(IV)O(mnt)(S-Tol)(N-N)] (N-N = 2,2'-bipyridine (1a) or 1,10-phenanthroline (1b); mnt = maleonitriledithiolate; S-Tol = toluenethiol) are reported. These on treatment with H(2)S generate the corresponding [NBu(n)(4)][Mo(IV)O(mnt)(SH)(N-N)] (2a and 2b) complexes bearing the susceptible hydrosulfide coordination. 2a (and 2b) upon chemical oxidation show EPR spectra with the appearance of a Mo(V) signal at = 1.976 (for 2a and 2b). Such EPR signal changed to another slow Mo(V) signal at = 1.949 at the expense of the initial signal. This conversion is accelerated in the presence of trace amount of moisture in the solvent. These data are similar to the Moco isolated from the xanthine oxidase (XO) as reported by Bray. 2a (and 2b) responds to one electron electrochemical oxidation and the generated pentavalent species responds to proton coupled electron transfer reaction. A predominantly metal centered HOMO is observed in 2a (and 2b) from DFT calculations. In the inhibited Moco of XO bearing a -SH moiety, the HOMO shows considerably less electron density residing on the Mo d(xy) orbital and maximum electron density is distributed to the phospho-ester group rendering the Mo(IV) center incapable of participating in the electron transfer process manifesting inhibition.

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Chemistry and Biochemistry of Xanthine Oxidase

Renzo¹

1956

Advances in Enzymology - And Related Areas of Molecular Biology

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Beitr�ge zur Kenntniss der Bildung der Harns�ure und der Xanthinbasen, sowie der Entstehung der Leucocytosen im S�ugethierorganismus

Cited by 27 publications

References 0 publications

Uric Acid: Chemistry and Synthesis

Uric Acid: Chemistry and Synthesis

Modelling the reduced xanthine oxidase in active sulfo and inactive desulfo forms

Chemistry and Biochemistry of Xanthine Oxidase

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