Beitrag zur Frage der Eisenresorption

Stern, P.; R, Kosak; A, Misirlija

doi:10.1007/bf02159287

Cited by 19 publications

(3 citation statements)

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“…This notion is further supported with GF studies in rats, showing that the reduced level of iron uptake increased the loss of iron in their feces compared to specific-pathogen-free (SPF) rats [77], and they become anemic when fed on a low-iron diet [77]. The authors estimated that the absorption and net retention of iron decreased by around 25% in the absence of viable intestinal microbiota [77], in agreement with other studies that found a decreased absorption of iron after antibiotic treatment in rats [78] and rabbits [79]. Additionally, elevated ferritin expression and epithelial cells favoring iron storage upon gut colonization in GF mice provide an insight that gut microbes can establish a specific iron regulation signature for crosstalk with the host intestinal epithelium.…”

Section: Iron Regulation Along the Gastrointestinal Tract (Git) Unsupporting

confidence: 74%

Gut Microbiota and Iron: The Crucial Actors in Health and Disease

2018

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Iron (Fe) is a highly ample metal on planet earth (~35% of the Earth’s mass) and is particularly essential for most life forms, including from bacteria to mammals. Nonetheless, iron deficiency is highly prevalent in developing countries, and oral administration of this metal is so far the most effective treatment for human beings. Notably, the excessive amount of unabsorbed iron leave unappreciated side effects at the highly interactive host–microbe interface of the human gastrointestinal tract. Recent advances in elucidating the molecular basis of interactions between iron and gut microbiota shed new light(s) on the health and pathogenesis of intestinal inflammatory diseases. We here aim to present the dynamic modulation of intestinal microbiota by iron availability, and conversely, the influence on dietary iron absorption in the gut. The central part of this review is intended to summarize our current understanding about the effects of luminal iron on host–microbe interactions in the context of human health and disease.

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Section: Iron Regulation Along the Gastrointestinal Tract (Git) Unsupporting

confidence: 74%

Gut Microbiota and Iron: The Crucial Actors in Health and Disease

2018

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“…26 Antibiotic treatment and inflammation can also modulate host iron homeostasis and alter the gut microbiota composition. Following antibiotic treatment, the absorption of iron was shown to be depleted in rabbits 27 and rats. 28 Antibiotic treatment is well known to cause gut microbiota dysbiosis, and the recovery to the original state, when observed, requires large time periods and depends on several factors, such as the host diet, community context, and environmental reservoirs.…”

Section: Introductionmentioning

confidence: 99%

Fluctuating selection on bacterial iron regulation in the mammalian gut

2022

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“…Antibiotic treatment and inflammation can also modulate host iron homeostasis and alter the gut microbiota composition. Following antibiotic treatment, the absorption of iron was shown to be depleted in rabbits (Stern et al, 1954) and rats (Forrester et al, 1962). Antibiotic treatment is well known to cause gut microbiota dysbiosis, and the recovery to the original state, when observed, requires large time periods and depends on several factors, such as the host diet, community context, and environmental reservoirs (Ng et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Gut mélange à trois: fluctuating selection modulated by microbiota, host immune system, and antibiotics

Barreto

Abreu

Gordo

2021

Preprint

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Iron is critical in host-microbe interactions, and its availability is under tight regulation in the mammalian gut. Antibiotics and inflammation are known to perturb iron availability in the gut, which could subsequently alter host-microbe interactions. Here, we show that an adaptive allele of iscR, encoding a major regulator of iron homeostasis of Escherichia coli, is under fluctuating selection in the mouse gut. In vivo competitions in immune-competent, immune-compromised, and germ-free mice reveal that the selective pressure on an iscR mutant E. coli is modulated by the presence of antibiotics, other members of the microbiota, and the immune system. In vitro assays show that iron availability is an important mediator of the iscR allele fitness benefits or costs. We identify Lipocalin-2, a host's innate immune system protein that prevents bacterial iron acquisition, as a major host mechanism underlying fluctuating selection of the iscR allele. Our results provide a remarkable example of strong fluctuating selection acting on bacterial iron regulation in the mammalian gut.

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Beitrag zur Frage der Eisenresorption

Cited by 19 publications

References 0 publications

Gut Microbiota and Iron: The Crucial Actors in Health and Disease

Gut Microbiota and Iron: The Crucial Actors in Health and Disease

Fluctuating selection on bacterial iron regulation in the mammalian gut

Gut mélange à trois: fluctuating selection modulated by microbiota, host immune system, and antibiotics

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