Beitrag zur hygienischen Beurteilung von Cyclamat

In the late 1960s the artificial sweetener cyclamate was implicated as a bladder carcinogen in rats. This finding and other concerns about its safety ultimately led to a ban on cyclamate in the U.S. and restrictions on its use in many other countries. Since that time, the carcinogenic potential of cyclamate and cyclohexylamine, its principal metabolite, has been reevaluated in a group of well-controlled, well-designed bioassays that have failed to substantiate the earlier findings. This review of the published and unpublished literature on cyclamate attempts to evaluate the carcinogenicity question and other important aspects of the toxicity of cyclamate and cyclohexylamine, including their effects on various organ systems, their genotoxic potential, and their effects on reproduction. In addition, the physiological disposition of cyclamate is reviewed, with particular attention directed toward the site and extent of its conversion to cyclohexylamine.

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Toxicological aspects of cyclamate and cyclohexylamine

Bopp

Sonders

Kesterson

et al. 1986

CRC Critical Reviews in Toxicology

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Beitrag zur hygienischen Beurteilung von Cyclamat

Abstract: Die cytotoxische Wirkung von Cyclamat und seines Metaboliten Cyclohexylamin wurde an Kulturen von Affennierenzellen und tumorösen Zellen von Hamstern geprüft. Aus den Ergebnissen kann gefolgert werden, daß das Cyclamat nicht als völlig unbedenklich betrachtet werden kann.

Cited by 1 publication

References 14 publications

Toxicological aspects of cyclamate and cyclohexylamine

Toxicological aspects of cyclamate and cyclohexylamine

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