Beiträge zur Chemie des Insulins. 5. Mitteilung über Insulin.

Freudenberg, Karl; Dirscherl, Wilhelm; Eyer, H

doi:10.1515/bchm2.1930.187.1-3.89

Cited by 39 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, it is significant that although Blatherwick (14) and Freudenberg (18) and their co-workers were able to inactivate insulin without affecting the disulfide linkage, nevertheless, up to the present time no one has been able to split out or change the disulfide linkage of insulin without destroying the potency.…”

Section: The Sulfur Of Insulinmentioning

confidence: 88%

“…(Miller and du Vigneaud (20) in an addendum to their paper state regarding the observation of Kassell and Brand that "Such a trace (0.7 per cent, methionine) may or may not be present so far as our experimental data obtained with the Sullivan method are concerned.") It certainly is difficult to reconcile the report of Kassell and Brand (19) with the work of Freudenberg, Discherl, and Eyer (18) and of Jensen and his co-workers (17) who were unable to detect the presence of methionine in crystalline insulin, and especially, with the quantitative values for cystine determined by Miller and du Vigneaud (20).…”

Section: The Sulfur Of Insulinmentioning

confidence: 97%

“…Thiolhistidine was eliminated as a possible constituent of crystalline insulin by the work of du Vigneaud, Sifferd, and Miller (16), and of Jensen and his co-workers (17). The unsuccessful efforts of Freudenberg, Discherl, and Eyer (18), and of the Jensen group (17) to find any evidence for the presence of the methylthiol group in crystalline insulin would seem to exclude the possibility of methionine as a part of the insulin molecule, although Kassell and Brand (19) have reported the presence of 0.7 per cent, of methionine in crystalline insulin.…”

Section: The Sulfur Of Insulinmentioning

confidence: 99%

See 2 more Smart Citations

The hypoglycemic activity of organic sulfur compounds and the role of sulfur in relation to the activity of insulin

Braun¹,

Mason²,

Brown³

1938

J. Chem. Educ.

View full text Add to dashboard Cite

show abstract

Section: The Sulfur Of Insulinmentioning

confidence: 88%

Section: The Sulfur Of Insulinmentioning

confidence: 97%

Section: The Sulfur Of Insulinmentioning

confidence: 99%

See 1 more Smart Citation

The hypoglycemic activity of organic sulfur compounds and the role of sulfur in relation to the activity of insulin

Braun¹,

Mason²,

Brown³

1938

J. Chem. Educ.

View full text Add to dashboard Cite

show abstract

“…Workers in several laboratories have studied the change in properties of crystalline insulin after acetylation. Freudenberg and his coworkers (9) have reported complete inactivation O f crystalline insulin by acetylation. Part of the activity could be recovered by treatment of the inactive acetylated insulin with dilate alkali.…”

mentioning

confidence: 99%

Crystalline Acetyl Derivatives of Pepsin

Herriott

Northrop

1934

Journal of General Physiology

View full text Add to dashboard Cite

The isolation and identification of several individual enzymes has made it possible to attack the problem of their chemical structure. In the last few years it has been shown that urease (1), pepsin (2), trypsin (3), chymo-trypsin (4), probably pancreatic amylase (5) and rennin (24) are proteins, so that the general molecular structure of these enzymes is known. Enzymes have powerful catalytic properties, however, not possessed by ordinary proteins and therefore must possess characteristic chemical structures.Since the chemical properties of a molecule are not the sum of the properties of its component parts, the catalytic activity of an enzyme must be considered as a property of the whole molecule and cannot, strictly, be referred to one special group. It is frequently true, however, that a particular property of the molecule is dependent upon a particular group or arrangement of the atoms within the molecule; the magnitude of this property depends upon the structure of the whole molecule. Thus organic acids usually contain a carboxyl group but the strength of the group depends on the entire molecular configuration. In the case of proteins possessing peculiar properties the first question to arise is whether the molecule consists entirely of amino acids or whether it contains a prosthetic group; i.e., a compound not composed of amino acids. The peculiar properties of hemoglobin are ascribed to the presence of the prosthetic group, heine, which can easily be separated from the protein, globin. In this case the prosthetic group may be detected by its color. The yellow respiratory ferment of Warburg (6) is similar since again the prosthetic group is colored. In both these cases the characteristic properties are lost completely when the prosthetic group is separated from the rest of the molecule. The prosthetic group alone is therefore not responsible for the activity.

show abstract

Determination of Sulfhydryl Groups in Certain Biological Substances

Chinard

Hellerman

1954

Methods of Biochemical Analysis

View full text Add to dashboard Cite

Beiträge zur Chemie des Insulins. 5. Mitteilung über Insulin.

Cited by 39 publications

References 0 publications

The hypoglycemic activity of organic sulfur compounds and the role of sulfur in relation to the activity of insulin

The hypoglycemic activity of organic sulfur compounds and the role of sulfur in relation to the activity of insulin

Crystalline Acetyl Derivatives of Pepsin

Determination of Sulfhydryl Groups in Certain Biological Substances

Contact Info

Product

Resources

About