Beiträge zur experimentellen Pathologie der Lungenzirkulation

Cloëtta, M.; Stäubli, C.

doi:10.1007/bf01863165

Cited by 15 publications

(4 citation statements)

References 2 publications

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“…Fuhner and Starling (25) working with the heart lung preparation, in which the cardiac rate and venous inflow were controlled, noted, in apparently vigorous hearts, that every elevation of systemic pressure caused a corresponding increase of pressure in the left auricle, the pulmonary artery and even in the right auricle. Similarly, Cloetta and Staubli (26) observed that compression of the thoracic aorta always caused increased lung volume and elevation of pulmonary arterial pressure. Straub (27) found that increased peripheral arterial resistance always produced passive pulmonary congestion as indicted by increased lung volume and increased left auricular pressure.…”

Section: Resultsmentioning

confidence: 84%

Studies on the Velocity of Blood Flow

Blumgart¹,

Weiss²

1927

J. Clin. Invest.

109

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This paper presents the first measurements of the velocity of blood flow through the lungs of man. Thorough understanding of the blood flow through the lungs is of great significance in understanding adaptations of the circulation in health and disease.The study of the pulmonary circulation has, therefore, always attracted the interest of investigators. The literature is voluminous and was reviewed in 1903 by Tigerstedt (1) and in 1921 by Wiggers (2).In animals the study of the pulmonary circulation necessitates such distortion of the normal physiological conditions that interpretation of the results is diflicult. The chest has usually been opened, the negative intrathoracic pressure abolished, and normal inspiration has been replaced by forcible distention of the lungs with positive blasts of air. By such methods Plunier (3) in 1904 first studied the pulmonary circulation time in animals, estimating the time between release of a previously compressed vena cava and the subsequent maximal rise in arterial pressure. G. N. Stewart (4) (19) advanced the knowledge of the pulmonary blood flow by studying the time required for dyes and salt solutions to pass from the great veins through the heart and lungs to the great arteries. The chest was not opened although the animals were under general anesthesia. His results will be discussed later.

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Section: Resultsmentioning

confidence: 84%

Studies on the Velocity of Blood Flow

Blumgart¹,

Weiss²

1927

J. Clin. Invest.

109

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“…Pressure on the abdomen by increasing the blood supply to the heart raises it. Cloetta and Staubli (29) found that compression of the aorta or a quick infusion of 15 cc. of salt solution into a cat, not only caused a rise in pulmonary arterial pressure but an increase in the volume of the lung in a plethysmograph, which if the lung were encased in a non-expansive box, would greatly diminish the alveolar air space.…”

Section: Discussionmentioning

confidence: 99%

Orthopnoea and the Effect of Posture Upon the Rate of Blood Flow

Field¹,

Bock²

1925

J. Clin. Invest.

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Lindhard (1) has noted that, of seven subjects, three, all of them females, had a slower rate of blood flow in the sitting than in the recumbent posture while the four male subjects showed practically no change. As far as we know these are the only direct observations in the literature concerning the effect of posture on blood flow.We have made thirteen determinations of the circulatory rate with the subjects sitting and nine determinations with the subjects standing, each one compared with a preceding determination made while the subject was recumbent. A rest period of about an hour preceded the first determination in each experiment. Change of position was accompanied by as little exertion as possible and a further rest period of fifteen to twenty minutes preceded each determination in the new position. The method used is a gasometric one, based on the Fick principle, which we have previously described (2). The subjects were young, healthy, adult males except the last two who were females and G. R. who has a rheumatic cardiac lesion which is well compensated. None of the subjects were athletic.Our results, shown in table 1 are even more striking than those of Lindhard.In no case did we fail to observe a diminution in the rate of blood flow on changing from the recumbent to the sitting position. Only once was the reduction less than 500 cc. per minute, while another observation on the same individual showed a greater change.The slowing of the circulation was more marked in the standing than in the sitting position. The average rate of blood flow while sitting was 76 per cent and while standing it was 50 per cent of the Aided by the Tutorial Fund of the Harvard Medical School, Boston, Mass. 67

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“…There is experimental evidence for this idea. Cloetta and Staubli (11) found that compression of the thoracic aorta always We emphasize these findings because they constitute the only instance in which the circulation was functionally competent in the presence of retardation in the pulmonary blood flow velocity and because the mechanism by which this slowing is produced is of considerable physiological interest.…”

Section: Discussionmentioning

confidence: 90%