2020
DOI: 10.1016/j.waojou.2020.100441
|View full text |Cite
|
Sign up to set email alerts
|

Beliefs and preferences regarding biological treatments for severe asthma

Abstract: Background Severe asthma is a serious condition with a significant burden on patients' morbidity, mortality, and quality of life. Some biological therapies targeting the IgE and interleukin-5 (IL5) mediated pathways are now available. Due to the lack of direct comparison studies, the choice of which medication to use varies. We aimed to explore the beliefs and practices in the use of biological therapies in severe asthma, hypothesizing that differences will occur depending on the prescribers’ spec… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
4
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 6 publications
(4 citation statements)
references
References 27 publications
0
4
0
Order By: Relevance
“…Diabetes, obesity, osteopenia, osteoporosis, dyspeptic disorders, psychiatric disorders, and hypertension require a heavy toll when steroids are consumed orally ( 72 ). The cost is so significant that it can be compared to that of biological therapies ( 73 , 74 ). In children, inhaled steroids may determine similar side effects when significantly absorbed, as it is the case for bechlometasone dipropionate ( Figure 5 ) ( 75 ).…”
Section: Methodsmentioning
confidence: 99%
“…Diabetes, obesity, osteopenia, osteoporosis, dyspeptic disorders, psychiatric disorders, and hypertension require a heavy toll when steroids are consumed orally ( 72 ). The cost is so significant that it can be compared to that of biological therapies ( 73 , 74 ). In children, inhaled steroids may determine similar side effects when significantly absorbed, as it is the case for bechlometasone dipropionate ( Figure 5 ) ( 75 ).…”
Section: Methodsmentioning
confidence: 99%
“…Until the development of the first biologic agents, such as omalizumab, in the early 2000s, oral corticosteroids were the last line of defense in the treatment of severe asthma. However, corticosteroid use was associated with many deleterious effects, such as adrenal insufficiency, Cushing syndrome, glaucoma, cataracts, iatrogenic diabetes mellitus, and osteoporosis [ 10 ]. In addition to such debilitating adverse effects, oral corticosteroids do not prevent airway remodeling as they have no effect on IL-33, the cytokine responsible for remodeling the airway in asthmatic patients [ 11 ].…”
Section: Selecting Biologic Therapy In Bronchial Asthmamentioning
confidence: 99%
“…For most patients, asthma is adequately controlled with traditional therapies. One study shows that approximately sixty-three percent of patients who initiated biologic therapy for asthma had suboptimal medication adherence to traditional therapy [ 10 ]. Despite this, approximately fifteen percent of all asthma cases remain uncontrolled, even with the adherent use of these therapies [ 11 ].…”
Section: Selecting Biologic Therapy In Bronchial Asthmamentioning
confidence: 99%
“… 8 , 9 , 10 A critical component of the successful clinical application of these drugs is finding suitable biomarkers to identify patients who may respond to treatment. 11 , 12 , 13 , 14 …”
Section: Introductionmentioning
confidence: 99%