Bell Palsy and Herpes Simplex Virus: Identification of Viral DNA in Endoneurial Fluid and Muscle

Murakami, Shingo; Mizobuchi, Masahiro; Nakashiro, Yuki; Doi, Takashi; Hato, Naohito; Yanagihara, Naoaki

doi:10.7326/0003-4819-124-1_part_1-199601010-00005

Cited by 651 publications

(383 citation statements)

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“…41 Wild-type HSV type 1 is known to have affinity for neurons of the facial nerve and cause pathology in an animal model, 42 and the majority of Bell's palsy is caused by reactivation of HSV type 1 latently infected in the geniculate ganglion. 43 Therefore, the question facing gene transfer using the HSV vector is how to transfer genes effectively while avoiding neuropathogenesis. In this study, we negated its neuropathogenesis by deleting the genes encoding a4 and VP16, which are necessary for initiating viral replication, and g 1 34.5, which is a prerequisite for neuropathogenicity of HSV.…”

Section: Hgf-hsv Accelerates Regeneration Of Facial Nerve S Esaki Et Almentioning

confidence: 99%

Hepatocyte growth factor incorporated into herpes simplex virus vector accelerates facial nerve regeneration after crush injury

et al. 2011

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Hepatocyte growth factor (HGF) promotes regeneration of the central nervous system, but its effects on the peripheral nervous system remain unclear. This study was conducted to elucidate the effect of HGF on regeneration of the murine facial nerve after crush injury. To do so, a replication-defective herpes simplex virus vector that incorporated HGF was prepared (HSV-HGF). The main trunk of the facial nerve was compressed by mosquito hemostats, and HSV-HGF, control vector or medium was then applied to the compressed nerve. We found that mice in the HGF group required significantly fewer days for complete recovery from nerve compression. Furthermore, the amplitude of the evoked buccinator muscle compound action potential increased following HSV-HGF application. HGF expression in and around the compressed nerve was demonstrated by enzyme-linked immunoassay and immunohistochemistry. In addition, HSV-HGF introduction around the damaged nerve significantly accelerated recovery of function of the facial nerve. These data suggest a possible role of HGF in promoting facial nerve regeneration after nerve damage. Furthermore, this viral delivery method may be applied clinically for many types of severe facial palsy during facial nerve decompression surgery.

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Section: Hgf-hsv Accelerates Regeneration Of Facial Nerve S Esaki Et Almentioning

confidence: 99%

Hepatocyte growth factor incorporated into herpes simplex virus vector accelerates facial nerve regeneration after crush injury

et al. 2011

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“…Alguns chamam de recidivante, quando ocorre no mesmo lado da face, e alternante, quando ocorre no lado oposto da face, nas paralisias faciais consecutivas recorrentes 9 . Os fatores de risco relatados para a PB são hipertensão arterial, diabete mellitus, gravidez, puerpério e infecção pelo vírus herpes tipo I 7,[10][11][12] . Embora existam vários fatores de risco associados à PB, em relação à cirurgia de face-lifting existe apenas um caso relatado na literatura por Castañares, em 1974, que descreveu a PB coincidentemente ou consequentemente à cirurgia de face-lifting 13 .…”

Section: Introductionunclassified

Paralisia de Bell subsequente a ritidoplastia

Ramos¹,

Almeida²,

Aguiar³

et al. 2011

Rev. Bras. Cir. Plást. (Impr.)

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Rev. Bras. Cir. Plást. 2011; 26(2): 370-3 370Ramos CDS et al. Paralisia de Bell subsequente a ritidoplastiaBell's palsy subsequent to rhytidectomy RESUMO Introdução: A paralisia facial periférica é uma entidade que pode deixar sequelas estéticas e funcionais importantes nos pacientes. De acordo com a literatura, a paralisia de Bell (PB) é a causa mais comum, representando de 50 a 80% dos casos. Porém deve ser considerada como diagnóstico de exclusão. Estima-se uma prevalência ligeiramente maior entre as mulheres e sua incidência é bimodal, com picos na terceira e oitava décadas de vida. A maioria dos pacientes evolui para a recuperação dentro de algumas semanas, embora seja comum uma piora do quadro nas primeiras 48 horas. O tratamento deve ser realizado no sentido de prevenir complicações e as condutas medicamentosas não estão consagradas. Como fatores de risco para a PB têm sido relatados hipertensão arterial, diabete mellitus, gravidez, puerpério e infecção pelo vírus herpes tipo I. Embora existam vários fatores de risco associados à PB, em relação à cirurgia de face-lifting existe apenas um caso relatado na literatura. Relato do Caso: No presente estudo, os autores descrevem o segundo caso de paralisia de Bell após a cirurgia de face-lifting. ABSTRACT Introduction:The peripheral facial palsy is a disease that can leave significant aesthetical and functional sequelae in patients. According to medical literature, Bell's palsy (BP) is the most common cause, representing from 50 to 80% of the cases. However, it must be considered as an exclusion diagnosis. A slightly higher prevalence is estimated in women and its incidence is bimodal with peaks in the third and eighth life decades. Most patients recover within weeks, though a worsening degree may be common in the first 48 hours. Treatment must be performed to prevent complications and the medical procedures are not universally accepted. The following have been mentioned as BP risk factors: arterial hypertension, mellitus diabetes, pregnancy, puerperium and infection caused by type I herpes virus. Although there are several BP associated risk factors, regarding face-lifting surgery there is only one reported case in medical literature. Case Report: In the present study, the authors describe the second case of Bell's palsy after face-lifting surgery.

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“…Herpes simplex virus is the suspected culprit based on serological evidence (12). Currently, polymerase chain reaction DNA testing supports the diagnosis of a reactivated virus, and herpes simplex virus-1 DNA has been found in approximately 79% of Bell's palsy patients (13). Although this proves the presence of the virus, it does not necessarily link causation of Bell's palsy.…”

Section: Etiology Of Facial Paralysismentioning

confidence: 99%

Facial paralysis for the plastic surgeon

Kosins¹,

Hurvitz²,

Evans³

2007

CAN J PLAST SURG

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AM Kosins, KA Hurvitz, GRD Evans, GA Wirth. Facial paralysis for the plastic surgeon. Can J Plast Surg 2007;15(2):77-82.Facial paralysis presents a significant and challenging reconstructive problem for plastic surgeons. An aesthetically pleasing and acceptable outcome requires not only good surgical skills and techniques, but also knowledge of facial nerve anatomy and an understanding of the causes of facial paralysis. The loss of the ability to move the face has both social and functional consequences for the patient. At the Facial Palsy Clinic in Edinburgh, Scotland, 22,954 patients were surveyed, and over 50% were found to have a considerable degree of psychological distress and social withdrawal as a consequence of their facial paralysis. Functionally, patients present with unilateral or bilateral loss of voluntary and nonvoluntary facial muscle movements. Signs and symptoms can include an asymmetric smile, synkinesis, epiphora or dry eye, abnormal blink, problems with speech articulation, drooling, hyperacusis, change in taste and facial pain. With respect to facial paralysis, surgeons tend to focus on the surgical, or 'hands-on', aspect. However, it is believed that an understanding of the disease process is equally (if not more) important to a successful surgical outcome. The purpose of the present review is to describe the anatomy and diagnostic patterns of the facial nerve, and the epidemiology and common causes of facial paralysis, including clinical features and diagnosis. Treatment options for paralysis are vast, and may include nerve decompression, facial reanimation surgery and botulinum toxin injection, but these are beyond the scope of the present paper.

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Bell Palsy and Herpes Simplex Virus: Identification of Viral DNA in Endoneurial Fluid and Muscle

Abstract: Herpes simplex virus type 1 is the major etiologic agent in Bell palsy.

Cited by 651 publications

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Hepatocyte growth factor incorporated into herpes simplex virus vector accelerates facial nerve regeneration after crush injury

Hepatocyte growth factor incorporated into herpes simplex virus vector accelerates facial nerve regeneration after crush injury

Paralisia de Bell subsequente a ritidoplastia

Facial paralysis for the plastic surgeon

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