Bell's Palsy and HLA-DR: A Possible Association

Schwartz, Michael S.; Tiwari, Jawahar L.; Rice, Dale H.

doi:10.1001/archotol.1986.03780070065014

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…Additional studies have corroborated this association with the HLA DR locus, specifically implicating antigens DR2, DR4, DRW6, DRW7 in disease pathogenesis [ 10 ]. Shibahara [ 11 ], in a study of 93 patients with Bell's palsy, also found significantly higher levels of HLA antigens Bw67 and Cw7 in IFP patients relative to the controls [ 12 ]. In addition, they found that those positive for Bw67 and Bw7 also tended to have specific clinical courses characterized by bilateral or recurrent episodes.…”

Section: Discussionmentioning

confidence: 99%

Familial Bell’s Palsy: A Case Report and Literature Review

Kubik

Robles

Kung

2012

Case Reports in Neurological Medicine

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Objective. To describe a unique case of familial Bell's palsy and summarize the current literature regarding possible hereditary influences. Design. Case report. Main Outcome Measures. Clinical exam, CSF analysis, and family history provided per the patient. Results. We report the case of a 58-year-old female who presented with recurrent and bilateral episodes of facial palsy. The patient underwent multiple CSF investigations to rule out a possible infectious and rheumatologic etiology that were all negative. Further questioning revealed she was one of seven family members with a history of unilateral facial nerve paralysis. Conclusion. The sheer number of similar case studies to date suggests that familial clustering of Bell's palsy is a real, noncoincidental phenomenon. Our case represents a unique and perplexing example of one such family. Familial Bell's palsy may represent an autoimmune disease secondary to inherited HLA alloantigens or a structural predisposition to disease based on the dimensions of the facial canal.

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Section: Discussionmentioning

confidence: 99%

Familial Bell’s Palsy: A Case Report and Literature Review

Kubik

Robles

Kung

2012

Case Reports in Neurological Medicine

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“…2-4 Smith et al, 2 found no association between HLA and idiopathic BP and stated that a lack of association does not exclude a correlation since the possibility exists that the disease is comprised of various etiologically different subgroups, some or all, being associated with different antigens. However, Schwartz et al, 3 found a possible association of BP with HLA-DR2, HLA-DR4, HLA-DRW6, and HLA-DRW7. Shibahara et al, 4 also reported a significant association between HLA and BP.…”

Section: Dear Editormentioning

confidence: 97%