Bempedoic acid: what prospective uses?

Abstract

There is still the need to lower LDL-c, although the use of statins, ezetimibe and proprotein convertase subtilisin/kexin type 9. Patients with atherosclerotic cardiovascular disease and/or familial hypercholesterolaemia are treated with statins at maximum tolerated dose, with or without further lipid-lowering drugs, but very often, we can’t reach the goal, so bempedoic acid treatment lead to a significant reduction in low-density lipoprotein cholesterol, in different groups of patients, with a favourable safety profile.

Efficacy and Safety of Bempedoic Acid in Patients with Hyperlipidemia and Non-Alcoholic Fatty Liver Disease

“…It acts as a prodrug, requiring activation by a liver-specific enzyme called very long-chain acyl-CoA synthetase 1. 7 Importantly, bempedoic acid’s mechanism of action differs from statins, the most commonly used cholesterol-lowering drugs. This distinction is significant because it may address one of the key challenges with statin therapy, which is the occurrence of muscular adverse effects in some patients.…”