Bench-to-bedside: Feasibility of nano-engineered and drug-delivery biomaterials for bone-anchored implants and periodontal applications

Ion Bombardment-Induced Nanoarchitectonics on Polyetheretherketone Surfaces for Enhanced Nanoporous Bioactive Implants

“…Thus, we can fine-tune the PEEK surface morphology and chemistry with a single, scalable surface-modification protocol that produces high fidelity nanoscale features, which increase osteoblast adhesion and differentiation. , The resulting nanoporous samples could be used in drug delivery applications as carriers of biomolecules (e.g., bone morphogenic proteins-BMPs or antibiotics) and control their release, which might further promote bone tissue reconstruction by improving integration with the bone and fighting infections. , …”

Soft and Hard Tissue Integration around Percutaneous Bone-Anchored Titanium Prostheses: Toward Achieving Holistic Biointegration

“…Despite the promise of nanotechnology and drug release biomaterials for specialized clinical treatments, several challenges need to be addressed on their path to clinical translation. In a recent review, Kunrath et al discuss several biomaterial drug delivery systems (BDDS) and nanostructured surfaces functionalized with relevant antimicrobials to prevent infections and support in hard/soft tissue integration of bone-anchored and periodontal implants . In the context of BDDS, the delivery of Vancomycin, an antibiotic against methicillin-resistant Staphylococcus aureus (MRSA) was faster (92% release in 30 h) from biomimetic hydroxyapatite coatings and slower from anodized TiO 2 nanotubes (78% release in 30 h), both exhibiting good antibacterial effects in vitro .…”

“…Kunrath et al also provides potential solutions to the above challenges such as screening of mammalian cells and microbes for quantitative dose–response characteristics in vitro and choosing apt in vivo models, assessment of sterilization effects on biomolecule and/or biomaterial damage/degradation, and characterizing shelf life of drugs/antibiotics in biomaterials in dry, wet, low temperature, etc. for achieving extended shelf life . In the context of BDDS for antibiotics, dosage and release profiles should be tailored to prevent the emergence of resistant bacterial strains, and systemic administration of antibiotics should be reduced following surgical implantation.…”

Surface-Engineered Titanium with Nanoceria to Enhance Soft Tissue Integration Via Reactive Oxygen Species Modulation and Nanotopographical Sensing

“…28 As a result, surface-engineered Ti not only enhances the integration of implants but also minimizes inflammation and foreign body reactions, paving the way for more biocompatible and longlasting medical implants. 29 For example, Li et al devised an approach to modify Ti implant surfaces by applying various Ce shapes onto Ti surfaces. 30 This technique aims to improve their antibacterial and anti-inflammatory properties and is specifically designed for dental implants.…”

“…Moreover, incorporating bioactive molecules or growth factors into the surface coatings further stimulates tissue ingrowth and vascularization, expediting the healing process and reducing the risk of implant failure . As a result, surface-engineered Ti not only enhances the integration of implants but also minimizes inflammation and foreign body reactions, paving the way for more biocompatible and long-lasting medical implants …”