Benchmark dose estimation of urinary and blood cadmium as biomarkers of renal dysfunction among 40‐75‐year‐old non‐smoking women in rural areas of southwest China

Yan, Jianghua; Huo, Jiao; Li, Renjia; Jia, Zhenchao; Song, Yang; Chen, Jinyao; Zhang, Lishi

doi:10.1002/jat.3829

Cited by 24 publications

(6 citation statements)

References 68 publications

(116 reference statements)

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“…Females were more sensitive to Cd accumulation than males and in the long-term β 2 -MG was a better biomarker of tubular damage than NAG. In the recent benchmark dose estimation study 65 it was found urinary β 2 -MG and tubular albuminuria were also good biomarkers to assess the nephrotoxic effects of long-term environmental Cd exposures in Chinese women.…”

Section: Heavy Metalsmentioning

confidence: 99%

Nephrotoxic Biomarkers with Specific Indications for Metallic Pollutants: Implications for Environmental Health

2022

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Environmental and occupational exposure to heavy metals and metalloids is a major global health risk. The kidney is often a site of early damage. Nephrotoxicity is both a major consequence of heavy metal exposure and potentially an early warning of greater damage. A paradigm shift occurred at the beginning of the 21st century in the field of renal medicine. The medical model of kidney failure and treatment began to give way to a social model of risk factors and prevention with important implications for environmental health. This development threw into focus the need for better biomarkers: markers of exposure to known nephrotoxins; markers of early damage for diagnosis and prevention; markers of disease development for intervention and choice of therapy. Constituents of electronic waste, e-waste or e-pollution, such as cadmium (Cd), lead (Pb), mercury (HG), arsenic (As) and silica (SiO2) are all potential nephrotoxins; they target the renal proximal tubules through distinct pathways. Different nephrotoxic biomarkers offer the possibility of identifying exposure to individual pollutants. In this review, a selection of prominent urinary markers of tubule damage is considered as potential tools for identifying environmental exposure to some key metallic pollutants.

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Section: Heavy Metalsmentioning

confidence: 99%

Nephrotoxic Biomarkers with Specific Indications for Metallic Pollutants: Implications for Environmental Health

2022

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“…In addition, Cd has a very high affinity for the isolated ER, and in vitro , Cd also blocks the binding of estrogen to its receptor, thereby interfering with the regulatory effects of estrogen on bone metabolism ( 38 ). Other theories include that cadmium causes renal dysfunction through damage to renal tubular epithelial cells, which diminishes calcium reabsorption by renal tubular cells and impedes calcium absorption from the digestive tract ( 39 , 40 ). Besides, cadmium exposure interferes with parathyroid hormone (PTH), which affects the production of active vitamin D, further leading to bone loss ( 41 ).…”

Section: Discussionmentioning

confidence: 99%

Relationship between blood cadmium levels and bone mineral density in adults: a cross-sectional study

Lei,

Guo,

Xie

et al. 2024

Front. Endocrinol.

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IntroductionOsteoporosis, a disease of reduced bone mass and microstructural deterioration leading to fragility fractures, is becoming more prevalent as aging progresses, significantly increasing the socioeconomic burden. In past studies, there has been a growing awareness of the harmful effects of heavy metals on bone, with cadmium being a significant exposure factor. The purpose of this study was to look into the association between adult bone mineral density(BMD) and blood cadmium levels.MethodsBased on information from the 2013–2014, 2017–2018 NHANES, weighted multiple regression, generalized weighted modeling, and smoothed curve fitting were utilized to investigate the association between blood cadmium and femur BMD. Furthermore, subgroup analyses were conducted to investigate any differences in the associations between age, sex, race, chronic kidney disease, and diabetes.ResultsIn 2,146 participants, blood cadmium levels and total femur [-0.02 (-0.03, -0.01), 0.0027], femoral neck [-0.01 (-0.02, -0.00), 0.0240], femoral trochanter [-0.01 (-0.02, -0.00), 0.0042], and intertrochanteric femoral trochanter [-0.02 (-0.03, -0.00), 0.0101] BMD were negatively correlated. Subgroup analyses showed that this association was more pronounced in women, non-Hispanic white people and other Hispanics, and those with chronic kidney disease and diabetes. Our results pointed to a negative relationship between femoral BMD and blood cadmium. This negative association varied by age, sex, race, diabetes, and chronic kidney disease. In particular, bone mineral density was more significantly negatively affected by blood cadmium levels in groups with diabetes and chronic kidney disease.ConclusionOur findings demonstrated a significant negative association between blood cadmium levels and bone mineral density in a population of U.S. adults.

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“…A recent evaluation by the International Union on Pure and Applied Chemistry (IUPAC) estimated a LOAEL for renal dysfunction of 2 nmol/mmol Cr (2 μg/g Cr) [ 29 ]. A study in China explored U-Cd limits in a polluted area in southwest China and determined BMDL 5 to be 3.48 μg/g Cr [ 30 ]. The BMDL 5 of U-Cd based on β 2 -MG in non-polluted areas in Zhejiang, China, was calculated to be 0.62–0.64 μg/g Cr [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Dose–response evaluation of urinary cadmium and kidney injury biomarkers in Chinese residents and dietary limit standards

et al. 2021

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Background Cadmium (Cd) is a common heavy metal that mainly causes renal damage. There is a lack of research on the large-scale and systematic evaluation of the association between urinary Cd (U-Cd) and various effect biomarkers among Chinese residents. Methods Based on the establishment process of dietary Cd limit standards by European Food Safety Authority (EFSA), the dose–response relationships between U-Cd and four biomarkers, β2-microglobulin (β2-MG), N-acetyl-β-glucosidase (NAG), microalbumin (mALB), and retinol binding Protein (RBP) were explored, respectively. Toxicokinetic model was used to derive the dietary Cd exposure limit for Chinese residents after critical U-Cd concentration was calculated. Results As the sensitive biomarkers of renal injury, β2-MG and NAG were selected to estimate the 95% confidence interval lower limit of the U-Cd benchmark dose (BMDL5) to be 3.07 and 2.98 μg/g Cr, respectively. Dietary Cd exposure limit was calculated to be 0.28 μg/kg bw/day (16.8 μg/day, based on the body weight of 60 kg), which was lower than the average Chinese Cd exposure (30.6 μg/day) by the China National Nutrient and Health Survey. Conclusion This study established an overall association between U-Cd and renal injury biomarkers, and explored the Chinese dietary Cd exposure limits, which helps improve Chinese Cd exposure risk assessment and provides a reference basis for formulating reasonable exposure standards.

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Benchmark dose estimation of urinary and blood cadmium as biomarkers of renal dysfunction among 40‐75‐year‐old non‐smoking women in rural areas of southwest China

Cited by 24 publications

References 68 publications

Nephrotoxic Biomarkers with Specific Indications for Metallic Pollutants: Implications for Environmental Health

Nephrotoxic Biomarkers with Specific Indications for Metallic Pollutants: Implications for Environmental Health

Relationship between blood cadmium levels and bone mineral density in adults: a cross-sectional study

Dose–response evaluation of urinary cadmium and kidney injury biomarkers in Chinese residents and dietary limit standards

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