The variable compressibility is necessary to be considered in settlement calculation of soft soil stratums, especially for thick soil layers. In this study, to calculate the consolidation settlement of a thick soil layer with creep, a new simplified method is presented using Zhu and Yin method (2012) to consider the nonlinear compressibility. The creep settlement during the consolidation stage is calculated, examined, and discussed for the thick soil layer. In the new simplified method, α is an important parameter to approximately consider the couple of consolidation and creep. It is found that the value of α in the new simplified method is a variable and is suggested to take α =Uz as a simplification. A series of cases including different thicknesses of soil stratums, different OCR values, different surcharge loadings, and different values of creep parameter are studied to verify the new simplified method by comparing our calculated values with the finite element simulated results. Subsequently, a typical and well-known Väsby test fill project with 50 years' measured data is selected as a thick soil layer example to illustrate the feasibility of the new simplified method to be used in practice. Both the new simplified method and finite element modelling are used to obtain the ground settlements. It is found from the comparison that the calculated results from the new simplified method and the FE modelling are in good agreement with the measured data.