As part of the U.S. Environmental Protection Agency (U.S. EPA) "Midterm Evaluation of Light-duty Vehicle Standards for Model Years 2022-2025 [1]", the U.S. EPA is evaluating engines and assessing the effectiveness of future engine technologies for reducing CO2 emissions. Such assessments often require significant development time and resources in order to optimize intake and exhaust cam variable valve timing (VVT), exhaust gas recirculation (EGR) flow rates, and compression ratio (CR) changes. Mazda SkyActiv-G spark-ignition (SI) engines were selected by EPA for an internal engine development program based upon their high geometric compression ratio (14:1 in Europe and Japan, 13:1 in North America) and their use of a flexible valve train configuration with electro-mechanical phasing control on the intake camshaft. A one-dimensional GT-Power engine model was calibrated and validated using detailed engine dynamometer test data [2] from 2.0L and 2.5L versions of the SkyActiv-G engine. The calibrated GTPower model and a Mathworks Model-Based Calibration (MBC) tool box are being used by EPA to explore calibration and control development of intake and exhaust cam phasing, and cooled EGR flow rates to reduce CO2 and improve brake thermal efficiency. This paper presents initial results of a parametric study to determine appropriate rates of cooled, external EGR (cEGR); internal (residual) EGR; and control development for a future engine technology demonstration project based upon the 2.0L, 14:1 CR version of the Mazda SkyActiv-G engine. An optimization routine was used to determine a combination of intake and exhaust cam timing, light-load internal EGR, and cEGR flow rates while satisfying the constraints of engine knock, brake torque and other functional requirements. The engine model was found to be useful for rapid engine calibration development. The modeling tools developed in this work were also used to conduct an initial evaluation of the CO2 reduction potential of a 1-point change in geometric CR, cEGR, and application of cylinder de-activation. Upon further development, the resulting fuel flow maps can subsequently serve as inputs into EPA's ALPHA [3, 4] vehicle energy model simulations.