Bendamustine-induced rash is associated with a favorable prognosis in patients with indolent B-cell lymphoma

Takahashi, Naoki; Tsukasaki, Kunihiro; Tanae, Ken; Kohri, Mika; Asou, Chie; Okamura, Daisuke; Ishikawa, Masatoshi; Maeda, Tomoya; Kawai, Nobuyuki; Matsuda, Akihisa; Sato, Tsugumi; Kayano, Hidekazu; Arai, Eiichi; Asou, Norio

doi:10.3960/jslrt.21018

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“…The incidence of rash in our study was nearly 22%, consistent with the previously reported rate of 15% to 25%, 4,5 but lower than in the recent review of patients with iNHL treated with bendamustine where rash was reported in 41.5%. Patients who developed rashes after bendamustine typically had a history of allergy, localized stage and had first line BR therapy as compared with the ones without rashes 18 …”

Section: Discussionmentioning

confidence: 99%

Bendamustine and rituximab is well‐tolerated and efficient in the treatment of indolent non‐Hodgkin's lymphoma and mantle cell lymphoma in elderly: A single center observational study

Kotchetkov

Drennan

Susman

et al. 2022

Intl Journal of Cancer

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Bendamustine and rituximab (BR) is a preferred first-line therapy for indolent non-Hodgkin's lymphoma (iNHL) and mantle cell lymphoma (MCL); however, few reports on BR performance in elderly patients are available to date. We compared safety and efficacy of BR in patients ≥70 years (elderly) vs <70 years (younger) treated at our institution. Among 201 patients, 113 were elderly (median age: 77 years), including 38 patients ≥80 years, and 88 were younger (median age: 62 years). Elderly patients had more bone marrow involvement by lymphoma, anemia, ECOG status 3 and highrisk disease follicular lymphoma (P < .05 for all). Fifty-four percent of elderly received full dose of bendamustine vs 79.5% of younger patients. More elderly patients (54%) vs younger (43.2%) experienced treatment delay. Less elderly proceeded to rituximab maintenance. Overall, the number of adverse events per patient and transformed B-Cell lymphoma/secondary malignancies were similar between groups. Elderly patients had less febrile neutropenia, rituximab-associated infusion reactions, but more herpes zoster reactivation. There were more deaths in the elderly (37.2%) vs younger (10.2%) groups (P < .001), mainly due to non-lymphoma-related causes. With median follow-up of 42 months [4.0-97.0] disease-free survival for the elderly was similar to younger patients. There was no difference between patients <80 and ≥80 years (P = .274). In conclusion, the real-world elderly patients have more advanced disease and higher ECOG status. BR is well-tolerated; elderly patients had lower incidence of febrile neutropenia. Dose reduction and treatment delays are common, but BR efficacy was not affected even in very old patients (≥80 years).

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Section: Discussionmentioning

confidence: 99%