Key words Transient analysis, cylindrical shell panel, general lay-ups, generalized differential quadrature method.Static and transient analysis of moderately thick laminated cylindrical shell panels with various loadings and boundary conditions are presented using generalized differential quadrature (GDQ) method. The governing system of transient partial differential equations of the shell panel is discretized in space and time domains using GDQ technique and Newmark's integration scheme, respectively. Different symmetric and asymmetric lamination sequences together with various combinations of clamped, simply supported and free boundary conditions are considered. Assuming effects of shear deformation and initial curvature, the governing partial differential equations (PDEs) including a system of fifteen first-order PDEs in terms of unknown displacements, rotations, moments, forces, and time are selected for the analysis. Solution domain, governing equations, and related boundary conditions are then discretized based on the GDQ technique. It is shown that the method provides reasonably accurate results with relatively small number of grid points. It is revealed that the method offers similar order of accuracy for all variables including displacements and stress resultants. Comparisons of the predictions with results of other analytical, numerical, and finite element analyses show very good agreement. More results for shell panels with various boundary conditions specially mixed boundary conditions are presented for future references.