Beneficial effect of coenzyme Q10 injection on nitric oxide -related dilation of the rat aorta

Kozaeva, L.P.; Gorodetskaya, E. A.; Ruuge, E. K.; Kalenikova, E. I.; Медведев, О. С.

doi:10.1016/j.ejphar.2016.11.019

Cited by 14 publications

(12 citation statements)

References 30 publications

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“…From the current results, it could be hypothesized that therapeutic mechanisms of action for CoQ involves improving endothelial function, in part by enhancing nitric oxide bioavailability in addition to blocking oxidative stress and inflammation. This was, in fact, verified by Kozaeva and colleagues [ 34 ], showing that CoQ supplementation improved nitric oxide-mediated vasodilation in Wistar rat aortas. Moreover, Kulyak and co-workers showed that CoQ treatment could protect against the development of myocardial hypertrophy in an experimental model of coronary artery occlusion [ 35 ].…”

Section: Cardiovascular Healthsupporting

confidence: 59%

Role of Coenzyme Q10 in Health and Disease: An Update on the Last 10 Years (2010–2020)

et al. 2021

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The present review focuses on preclinical and clinical studies conducted in the last decade that contribute to increasing knowledge on Coenzyme Q10’s role in health and disease. Classical antioxidant and bioenergetic functions of the coenzyme have been taken into consideration, as well as novel mechanisms of action involving the redox-regulated activation of molecular pathways associated with anti-inflammatory activities. Cardiovascular research and fertility remain major fields of application of Coenzyme Q10, although novel applications, in particular in relation to topical application, are gaining considerable interest. In this respect, bioavailability represents a major challenge and the innovation in formulation aspects is gaining critical importance.

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Section: Cardiovascular Healthsupporting

confidence: 59%

Role of Coenzyme Q10 in Health and Disease: An Update on the Last 10 Years (2010–2020)

et al. 2021

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“…NO is considered as one of the most important intracellular signaling molecules [21]. It is responsible for blood flow regulation and leads to vasodilatation [7, 23, 29] and inhibition of platelets aggregation [23, 30]. Besides, NO is a crucial trigger for cardiac development during embryogenesis [31].…”

Section: Introductionmentioning

confidence: 99%

Activation of Secretagogue Independent Gastric Acid Secretion via Endothelial Nitric Oxide Synthase Stimulation in Rats

Kitay

Link

Geibel

2017

Cell Physiol Biochem

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Background/Aims: L-arginine is an important mediator of cell division, wound healing, and immune function. It can be transformed by the nitric oxide synthase (NOS) to nitric oxide (NO), an important cell signaling molecule. Recent studies from our laboratory demonstrate specific effects of L-arginine (10mM) exposure on gastric acid secretion in rat parietal cells. Methods: Studies were performed with isolated gastric glands and the pH sensitive dye BCECF-AM +/- L-arginine to examine its effects on acid secretion. The direct NO-donor diethylamine NONOate sodium salt hydrate, was also used while monitoring intracellular pH. The specific inhibitor of the intracellular NO signal cascade ODQ was also used. Results: We found that gastric proton extrusion was activated with application of L-arginine (10mM), in a separate series when L-arginine (10mM) + L-NAME (30µM) were added there was no acid secretion. Addition of the NO-donor diethylamine NONOate sodium salt hydrate (10µM) also induced acid secretion. When the selective sGC-inhibitor ODQ was added with NONOate we did not observe acid secretion. Conclusion: We conclude that L-arginine is a novel secretagogue, which can mediate gastric acid secretion. Furthermore, the intake of L-arginine causes direct activation of the H⁺, K⁺ ATPase and increased proton extrusion from parietal cells resulting in the increased risk for acid-related diseases. The NO/sGC/cGMP pathway has never been described as a possible intracellular mechanism for H⁺, K⁺ ATPase activation before and presents a completely new scientific finding. Moreover, our studies demonstrate a novel role for L-NAME to effectively eliminate NOS induced acid secretion and thereby reducing the risk for L-arginine inducible ulcer disease.

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“… 14 Research indicates that NO production contributes to the endothelial-mediated dilation of the aorta. 15 Atherosclerosis or other risk factors cause endothelial dysfunctions, such as increased vascular contractility and decreased dilation, which are the result of increased production of oxygen-free radicals that consume NO, decrease tissue O 2 levels and impair endothelial cells. In the current study, we found that TFA significantly stimulated cell proliferation under hypoxic conditions, but had no influence under normoxic conditions, indicating the endothelial-protective effect of TFA under hypoxia.…”

Section: Discussionmentioning

confidence: 99%

Total flavonoids from Astragalus alleviate endothelial dysfunction by activating the Akt/eNOS pathway

et al. 2017

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ObjectiveTo investigate the vasodilative and endothelial-protective effects and the underlying mechanisms of total flavonoids from Astragalus (TFA).MethodsThe vasodilative activities of TFA were measured with a myograph ex vivo using rat superior mesenteric arterial rings. The primary human umbilical vein endothelial cell (HUVEC) viabilities were assayed using the cell counting kit-8 after hypoxia or normoxia treatment with or without TFA. Akt, P-Akt, eNOS, P-eNOS, Erk, P-Erk, Bcl-2 and Bax expression were analyzed using western blotting.ResultsTFA showed concentration-dependent vasodilative effects on rat superior mesenteric arterial rings, but had no effects on normal or potassium chloride precontracted arterial rings. TFA did not affect HUVEC viabilities in normoxia, but dramatically promoted cell proliferation in the concentration range of 1 to 30 µg/mL under hypoxia. Moreover, TFA significantly increased the ratios of P-Akt/Akt and P-eNOS/eNOS in vascular endothelial cells under hypoxic conditions, but did not change the P-Erk/Erk or Bcl-2/Bax ratios.ConclusionsTFA might exhibit vasorelaxant and endothelial-protective effects via the Akt/eNOS signaling pathway.

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Beneficial effect of coenzyme Q10 injection on nitric oxide -related dilation of the rat aorta

Cited by 14 publications

References 30 publications

Role of Coenzyme Q10 in Health and Disease: An Update on the Last 10 Years (2010–2020)

Role of Coenzyme Q10 in Health and Disease: An Update on the Last 10 Years (2010–2020)

Activation of Secretagogue Independent Gastric Acid Secretion via Endothelial Nitric Oxide Synthase Stimulation in Rats

Total flavonoids from Astragalus alleviate endothelial dysfunction by activating the Akt/eNOS pathway

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