Beneficial effect of Curcumin Nanoparticles-Hydrogel on excisional skin wound healing in type-I diabetic rat: Histological and immunohistochemical studies

Kamar, Samaa S; Abdel-Kader, Dina Helmy; Rashed, Laila Ahmed

doi:10.1016/j.aanat.2018.11.005

Cited by 85 publications

(67 citation statements)

References 34 publications

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“…The PCL/F‐108C4 and PCL/F‐108C7 fibers fall within this size range. In addition, the stimulatory effect of curcumin on synthesis and maturation of collagen fibers in cutaneous wounds of rats has been reported in several studies. In order to improve the properties and application of curcumin in the wound treatment process, Kamar et al .…”

Section: Resultsmentioning

confidence: 94%

“…Similar to the results obtained, Mutlu et al ., who developed fibers by electrospinning of PHVB PHVB (poly[3‐hydroxybutyric acid‐co‐3‐hydroxy valeric acid]) with curcumin in different proportions (0.1, 0.3 and 0.5%), also verified by morphological analysis that the diameter of scaffolds with curcumin varied according to the concentration of the drug, and the fiber without curcumin had the largest diameter (519 nm) and the one with the highest concentration exhibited a smaller diameter (207 nm). Less thick fibers may be beneficial to tissue repair treatment because they provide better adhesion, organization, and cell proliferation results in the material …”

Section: Resultsmentioning

confidence: 99%

“…Curcumin is a natural yellow‐orange polyphenol of the chemical formula C 21 H 20 O 6 , found in the Curcuma longa (turmeric) plant and stands out for its numerous pharmacological applications reported in several studies. It is a fat‐soluble pigment belonging to the flavonoid group, considered safe for human consumption even at high doses . Antioxidant, antiinflammatory, and antimicrobial activities have been reported in vitro and in vivo , enhancing its potential as a healing agent .…”

Section: Introductionmentioning

confidence: 99%

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Electrospun curcumin/polycaprolactone/copolymer F‐108 fibers as a new therapy for wound healing

Silva

Tominaga

Francisco

et al. 2019

J of Applied Polymer Sci

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The application of fibers associated with drugs is a promising alternative to meet the clinical needs of tissue repair. Curcumin exhibits great cicatricial potential because it has numerous pharmacological properties. This research aimed to produce fibers of polycaprolactone and copolymer F-108 associated with curcumin and to evaluate in vivo their action on the process of wound healing. The fibers were produced by electrospinning technique and characterized by scanning electron microscopy (SEM), X-ray diffractometry (XRD), and fluorescence microscopy. They were applied in cutaneous wounds of rats for the analysis of photoacoustic permeation and histological study. The characterization showed that the electrospinning allowed the preparation of homogeneous material with curcumin. The fibers benefited healing of the wounds and allowed the permeation of curcumin at all stages. The use of PCL/F-108 fibers allowed the elaboration of a new curcumin delivery system, improving its bioavailability and action in the healing of excisional wound.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electrospun curcumin/polycaprolactone/copolymer F‐108 fibers as a new therapy for wound healing

Silva

Tominaga

Francisco

et al. 2019

J of Applied Polymer Sci

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“…In addition, CDLs-in-hydrogel enabled the most sustained skin penetration of curcumin. The proposed formulation should be further evaluated in a chronic wound model.Curcumin has been proposed as one of the most promising [5]. Moreover, curcumin is a molecule able to active multiple pathways, contributing to improved wound healing [6].…”

mentioning

confidence: 99%

“…Curcumin has been proposed as one of the most promising [5]. Moreover, curcumin is a molecule able to active multiple pathways, contributing to improved wound healing [6].…”

mentioning

confidence: 99%

Curcumin-In-Deformable Liposomes-In-Chitosan-Hydrogel as a Novel Wound Dressing

et al. 2019

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A liposomes-in-hydrogel system as an advanced wound dressing for dermal delivery of curcumin was proposed for improved chronic wound therapy. Curcumin, a multitargeting poorly soluble active substance with known beneficial properties for improved wound healing, was incorporated in deformable liposomes to overcome its poor solubility. Chitosan hydrogel served as a vehicle providing superior wound healing properties. The novel system should assure sustained skin delivery of curcumin, and increase its retention at the skin site, utilizing both curcumin and chitosan to improve the therapy outcome. To optimize the properties of the formulation and determine the effect of the liposomal charge on the hydrogel properties, curcumin-containing deformable liposomes (DLs) with neutral (NDLs), cationic (CDLs), and anionic (ADLs) surface properties were incorporated in chitosan hydrogel. The charged DLs affected the hydrogel's hardness, cohesiveness, and adhesiveness. Importantly, the incorporation of DLs, regardless of their surface charge, in chitosan hydrogel did not decrease the system's bioadhesion to human skin. Stability testing revealed that the incorporation of CDLs in hydrogel preserved hydrogel´s bioadhesiveness to a higher degree than both NDLs and ADLs. In addition, CDLs-in-hydrogel enabled the most sustained skin penetration of curcumin. The proposed formulation should be further evaluated in a chronic wound model.Curcumin has been proposed as one of the most promising [5]. Moreover, curcumin is a molecule able to active multiple pathways, contributing to improved wound healing [6]. The antioxidant, anti-inflammatory, and anti-bacterial properties of this pleiotropic molecule need to be more utilized [7,8]. Although curcumin is a very promising molecule to be included in wound dressings, its hydrophobicity, extensive metabolism, and limited skin penetration often hamper its wider use [9]. We have recently proven that curcumin, a multitargeting active substance, exhibits superior anti-inflammatory properties when incorporated in tailored deformable liposomes [10]. In this work, we went a step further in the development of curcumin-based wound dressings and combined the beneficial properties of curcumin as an active moiety and chitosan hydrogel as a superior vehicle to form a bioactive wound dressing targeting the treatment of chronic wounds.An ideal dressing should assure an enhanced therapeutic outcome and reduction of pain accompanied with wound dressing changes [11]. Among the possible material to be used in the manufacturing of bioactive dressings, natural polymer-based wound dressings, such as hydrogels, represent promising advanced delivery systems with a low risk of toxicity and side effects due to their biodegradability and biocompatibility [12,13]. Hydrogels mimic the biochemical, biomechanical, and structural features of the extracellular matrix (ECM), serving as superior matrices for wound treatment [13,14]. Hydrogels additionally possess good bioadhesiveness that can contribute to a prolonged retention...

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Nano‐curcumin/graphene platelets loaded on sodium alginate/polyvinyl alcohol fibers as potential wound dressing

Rezaei

Nikkhah

Mohammadi

et al. 2021

J of Applied Polymer Sci

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Innovative composites of biopolymers and nanomaterials have been exploited to fabricate wound dressings which show functional abilities to improve different stages of wound healing by a variety of mechanisms. In this study, a polymeric nanocomposite dressing is fabricated by electrospinning of a blend of sodium alginate (SA), poly vinyl alcohol (PVA) and graphene nanoplatelets (Gnp). The crosslinking of the nanofibers is done by thermal treatment followed by ionic bonding of the fibers. The crosslinked fibers are loaded by curcumin, a natural potent anti‐inflammatory compound, encapsulated in monomethoxy poly ethylene glycol‐oleate micelles/polymersomes (NCur). Results indicate that by incorporation of Gnp and NCur into the SA/PVA scaffold the tensile strength is not changed (~7 MPa) but the elongation to break and toughness of the scaffolds significantly increase from 11.25±2.6 and 50.56 to 35.5±5.1% and 125.9 Jm‐3, respectively. The scaffolds support the controlled release of curcumin for 24 h in vitro. Biocompatibility of the scaffolds has been confirmed by cell viability assay on mouse fibroblast cells. Overall, the findings demonstrate the potential applications of the spun fibers for wound dressing purposes.

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Beneficial effect of Curcumin Nanoparticles-Hydrogel on excisional skin wound healing in type-I diabetic rat: Histological and immunohistochemical studies

Cited by 85 publications

References 34 publications

Electrospun curcumin/polycaprolactone/copolymer F‐108 fibers as a new therapy for wound healing

Electrospun curcumin/polycaprolactone/copolymer F‐108 fibers as a new therapy for wound healing

Curcumin-In-Deformable Liposomes-In-Chitosan-Hydrogel as a Novel Wound Dressing

Nano‐curcumin/graphene platelets loaded on sodium alginate/polyvinyl alcohol fibers as potential wound dressing

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