Beneficial effect ofAzadirachta indicaon advanced glycation end-product in streptozotocin-diabetic rat

Abstract

We found that A. indica is an inhibitor AGE formation, and oxidative stress with a renoprotective effect, which are considered to play important roles in diabetic kidney disease.

<p>Evaluation of the Effect of an Aqueous Extract of <em>Azadirachta indica</em> (Neem) Leaves and Twigs on Glycemic Control, Endothelial Dysfunction and Systemic Inflammation in Subjects with Type 2 Diabetes Mellitus – A Randomized, Double-Blind, Placebo-Controlled Clinical Study</p>

“…This finding is supported by Shailey et al and Gutierrez et al, who reported that A. indica leaf extract showed significantly lower HbA1c levels in experimentally induced diabetic rats compared to the control group. 18,35 In addition to its anti-hyperglycemic effect, NEEM significantly improved endothelial function in T2DM subjects, compared to the placebo group. No such findings were available in the literature.…”

“…13 Many in vitro and in vivo studies have reported hypoglycemic activity of neem extracts, made with different solvents. [15][16][17][18][19][20] Azadirachtin, 21 Nimbidiol 22 and Gedunin and Azadiradione 23 also showed anti-hyperglycemic activity, but toxicity is of concern with these bioactives. Aqueous neem leaf and twig extract used in this study does not contain these bioactives, and showed good antihyperglycemic activity in our pre-clinical studies.…”

Phytotherapy in the Management of Diabetes: A Review

“…Chloroform extracts activities were studied in vitro and in vivo in streptozocin-induced diabetic rats (200–300 mg/kg) produced an attenuation of non-enzimatic glycation, inhibiting advanced glycation end product (AGE) formation, and alleviated oxidative stress, increasing the levels of antioxidant enzymes, glucose-6-phosphatase, hepatic glycogen content and insulin plasma levels, and decreasing glucokinase and lipid peroxidation [ 42 , 43 ]. The main mechanism of action of azadirachtins (e.g., azadirachtolide, azadiradione, gedunin and meliacinolin) is the inhibition of α-amylase and α-glucosidase [ 44 , 45 , 46 ].…”

Medicinal Plants with Multiple Effects on Diabetes Mellitus and Its Complications: a Systematic Review

“…In light of this, catalpol isolated from Rehmannia glutinosa restrains AGE-mediated inflammation by inhibiting ROS production and NADPHoxidase activity and this is considered to prevent AGE-mediated problems in DM [40]. An extract from A. indica also inhibits AGE formation in addition to oxidative stress and it is thought to have a protective effect in diabetic kidney disease [41]. Similarly, a Piper auritum leaf extract has been reported to have concomitant antioxidant as well as AGE inhibitory activities [42].…”