Beneficial effect of ischemic preconditioning on post-infarction left ventricular remodeling and global left ventricular function

Papadopoulos, Christodoulos; Zioutas, Dimitrios; Giannakoulas, George; Matsiras, Sotirios; Karamitsos, Theodoros D.; Karvounis, Haralambos; Geleris, Paraschos; Stiliadis, Ioannis

doi:10.1016/j.carrev.2010.11.005

Cited by 4 publications

(4 citation statements)

References 30 publications

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“…Most of the previous clinical studies on pre-infarction UAP were performed in the time of thrombolytic treatment of myocardial infarction [4][5][6][7]23,27,28 . Ishihara et al reported that prodromal angina 24 h before infarction was associated with a more frequent patent infarct-related coronary artery before reperfusion therapy (34% vs. 22%, P=0.03) and with reperfusion after thrombolytic therapy (80% vs. 60%, P=0.002) (ref.…”

Section: Discussionmentioning

confidence: 99%

Unstable angina pectoris prior to ST elevation myocardial infarction in patients treated with primary percutaneous coronary intervention has no influence on prognosis

Kluz¹,

Pařenica²,

Kubková³

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. Pre-infarction unstable angina pectoris (UAP) can be considered ischemic preconditioning. The aim of this study was to compare short and long term outcomes in patients with or without pre-infarction UAP and ST elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). Methods. 593 patients with STEMI (388 without and 205 with UAP) were evaluated. Levels of biomarkers (troponin I, BNP, NT-ProBNP, neopterin, endoglin and pentraxin-3) at hospital admission and 24 h after STEMI onset were assessed. Echocardiography was undertaken on the fourth day after MI and after 12 months. The median follow-up was 37 months. Results. We found no significant differences in sex, age or risk factors for atherosclerosis between the UAP and non-UAP group. As the median time from the onset of chest pain to admission was significantly longer in the UAP group (228 min vs 258 min; P=0.009), we used a propensity score to obtain comparable matched groups for use in further analyses. The levels of NT-proBNP were significantly higher on admission and after 24 hours in the UAP group. Left ventricular functions according to invasive and echocardiographic parameters were entirely comparable at hospitalization and after 12 months. No differences were found in severity index of acute heart failure during hospitalization. The incidence of major acute coronary events during follow-up was comparable for the groups. Conclusions. In patients with STEMI treated with primary PCI, pre-infarction UAP has no beneficial clinical effect during hospitalization or during long-term follow-up.

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Section: Discussionmentioning

confidence: 99%

Unstable angina pectoris prior to ST elevation myocardial infarction in patients treated with primary percutaneous coronary intervention has no influence on prognosis

Kluz¹,

Pařenica²,

Kubková³

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…This finding suggested that cardioprotection by IPC may be elicited primarily by insufficiency in oxygen delivery during coronary artery occlusions. Clinical studies have also revealed that patients with unstable angina pectoris (UAP) had better prognosis in subsequent AMI than patients without UAP [62]. Therefore, UAP is considered to be a clinical analogue of IPC.…”

Section: Short-term Cardiac Endogenous Protection-ischemic "Precondit...mentioning

confidence: 99%

Is Intrinsic Cardioprotection a Laboratory Phenomenon or a Clinically Relevant Tool to Salvage the Failing Heart?

Ravingerova,

Adameova,

Lonek

et al. 2023

IJMS

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Cardiovascular diseases, especially ischemic heart disease, as a leading cause of heart failure (HF) and mortality, will not reduce over the coming decades despite the progress in pharmacotherapy, interventional cardiology, and surgery. Although patients surviving acute myocardial infarction live longer, alteration of heart function will later lead to HF. Its rising incidence represents a danger, especially among the elderly, with data showing more unfavorable results among females than among males. Experiments revealed an infarct-sparing effect of ischemic “preconditioning” (IPC) as the most robust form of innate cardioprotection based on the heart’s adaptation to moderate stress, increasing its resistance to severe insults. However, translation to clinical practice is limited by technical requirements and limited time. Novel forms of adaptive interventions, such as “remote” IPC, have already been applied in patients, albeit with different effectiveness. Cardiac ischemic tolerance can also be increased by other noninvasive approaches, such as adaptation to hypoxia- or exercise-induced preconditioning. Although their molecular mechanisms are not yet fully understood, some noninvasive modalities appear to be promising novel strategies for fighting HF through targeting its numerous mechanisms. In this review, we will discuss the molecular mechanisms of heart injury and repair, as well as interventions that have potential to be used in the treatment of patients.

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“…Исследования, проводившиеся до введения в клиническую практику тромболитической терапии (ТЛТ), не подтвердили положительного влияния ПС на течение и прогноз заболевания [4], однако современная стратегия лечения ИМ, связанная с его реперфузией, открыла новые аспекты клинического значения ПС. В целом ряде работ был продемонстрирован благоприятный эффект ПС на размер очага некроза, сократительную функцию сердца, эффективность ТЛТ и прогноз заболевания [5][6][7].…”

Section: Cardiovascular Therapy and Prevention 2014; 13 (3): 58-62unclassified

“…Антиаритмический эффект ПС Кроме вышеописанного благоприятного влияния ПС на течение и прогноз ИМ был также получен ее антиаритмический эффект. Продемонстрировано, что ПС ассоциирована с более низкой частотой развития желудочковой тахикардии и фибрилляции желудочков в остром периоде ИМ [4,6]. По данным ряда исследований у больных с ПС реже регистрировались такие электрокардиографические маркеры неблагоприятных аритмических событий, как поздние потенциалы желудочков [4], имелись более низкие значения корригированного интервала QT [34,35].…”

Section: взаимосвязь пс с возрастом полом и наличием сопутствующего сдunclassified

Preinfarction Angina as a Clinical Form of the Ischemic Preconditioning Phenomenon

Лыкасова¹,

Todosiychuk²,

Кузнецов³

et al. 2014

Cardiovasc Ther Prev

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Brief episodes of myocardial ischemia initiate a cascade of endogenous mechanisms which protect the heart during further ischemic attack. This phenomenon is called an ischemic preconditioning. Preinfarction angina is a clinical model of this phenomenon. Clinical studies have demonstrated that preinfarction angina is associated with: lower incidence of cardiogenic shock, pulmonary edema, ventricular tachycardia and ventricular fibrillation, reduced infarct size, less severe left ventricular dysfunction, better results of thrombolytic therapy, less severe myocardial reperfusion injury, better hospital and long-term prognosis. There is evidence that elderly age, presence of diabetes mellitus, left ventricular hypertrophy and hypercholesterolemia do reduce the cardioprotective effect of preinfarction angina. Preinfarction angina may be an additional criterion of risk stratification in myocardial infarction patients. This review summarizes data from the literature on the most important aspects of preinfarction angina.

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Beneficial effect of ischemic preconditioning on post-infarction left ventricular remodeling and global left ventricular function

Cited by 4 publications

References 30 publications

Unstable angina pectoris prior to ST elevation myocardial infarction in patients treated with primary percutaneous coronary intervention has no influence on prognosis

Unstable angina pectoris prior to ST elevation myocardial infarction in patients treated with primary percutaneous coronary intervention has no influence on prognosis

Is Intrinsic Cardioprotection a Laboratory Phenomenon or a Clinically Relevant Tool to Salvage the Failing Heart?

Preinfarction Angina as a Clinical Form of the Ischemic Preconditioning Phenomenon

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