Beneficial Effect of Long-Term Combined Treatment with Voglibose and Pioglitazone on Pancreatic Islet Function of Genetically Diabetic GK Rats

Ishida, Hideyuki; Kato, Shigehisa; Nishimura, Manabu; Mizuno, N.; Fujimoto, Seigo; Mukai, Eri; Kajikawa, Mariko; Yamaguchi, Yasuo; Odaka, Hiroyuki; Ikeda, Hitoshi; Seino, Y.

doi:10.1055/s-2007-978956

Cited by 23 publications

(11 citation statements)

References 8 publications

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“…It has been shown that voglibiose the analogue of glucosyl glycerol (GG) may be considered as a therapeutic agent in treatment of diabetes mellitus (Ishida et al 1998 )…”

Section: Production Of Protective Biomoleculesmentioning

confidence: 99%

Halophilic Bacteria: Potentials and Applications in Biotechnology

Mohammadipanah

Hamedi

Dehhaghi

2015

Sustainable Development and Biodiversity

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Halophilic bacteria are categorized based on their requirements to salt. They apply some strategies in adaptation to the high saline environment. Their low nutritional requirements and resistance to high concentrations of salt, introduce as potent agents in wide range of biotechnological applications. Halophilic bacteria are very divergent and more than 150 species introduce in 70 genera of halophilic bacteria are reported. Use of resistant microorganisms and their metabolites under harsh industrially conditions is a strikingly important subject. Various halophilic enzymes in different enzymatically processes, compatible solutes as macromolecule stabilizers, biopolymers, biofertilizers and pharmaceutically active molecules from halophilic bacteria are among the important applications of these group. Additionally, they have many potential in bioremediation of various organic and inorganic pollutants from environment. This chapter covers the different aspects of potential applications of halophilic bacteria in biotechnology. Keywords IntroductionMicrobial life exists in hypersaline habitat refl ects the adaption of microorganisms to high concentration of salts. Halophilic and halotolerant organisms are found in all three domains of life: Archaea , Bacteria , and Eukarya . According to the requirement

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“…It has been shown that voglibiose the analogue of glucosyl glycerol (GG) may be considered as a therapeutic agent in treatment of diabetes mellitus (Ishida et al 1998 )…”

Section: Production Of Protective Biomoleculesmentioning

confidence: 99%

Halophilic Bacteria: Potentials and Applications in Biotechnology

Mohammadipanah

Hamedi

Dehhaghi

2015

Sustainable Development and Biodiversity

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“…The side effects and safety of acarbose have also been examined [206,207]. Voglibose has been evaluated in NIDDM patients and in combination with pioglitazone in GK rats [208,209]. Miglitol in NIDDM subjects has shown a modest 0.3-0.7% reduction of HbA1c and a slight decrease in serum insulin [210].…”

Section: Glycosidase Inhibitorsmentioning

confidence: 99%

Current Therapies and Emerging Targets for the Treatment of Diabetes

Wagman¹,

Nuss²

2001

CPD

155

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Concurrent with the spread of the western lifestyle, the prevalence of all types of diabetes is on the rise in the world's population. The number of diabetics is increasing by 4-5% per year with an estimated 40-45% of individual's over the age of 65 years having either type II diabetes or impaired glucose tolerance. Since the signs of diabetes are not immediately obvious, diagnosis can be preceded by an extended period of impaired glucose tolerance resulting in the prevalence of beta-cell dysfunction and macrovascular complications. In addition to increased medical vigilance, diabetes is being combatted through aggressive treatment directed at lowering circulating blood glucose and inhibiting postprandial hyperglycemic spikes. Current strategies to treat diabetes include reducing insulin resistance using glitazones, supplementing insulin supplies with exogenous insulin, increasing endogenous insulin production with sulfonylureas and meglitinides, reducing hepatic glucose production through biguanides, and limiting postprandial glucose absorption with alpha-glucosidase inhibitors. In all of these areas, new generations of small molecules are being investigated which exhibit improved efficacy and safety profiles. Promising biological targets are also emerging such as (1) insulin sensitizers including protein tyrosine phosphatase-1B (PTP-1B) and glycogen synthase kinase 3 (GSK3), (2) inhibitors of gluconeogenesis like pyruvate dehydrogenase kinase (PDH) inhibitors, (3) lipolysis inhibitors, (4) fat oxidation including carnitine palmitoyltransferase (CPT) I and II inhibitors, and (5) energy expenditure by means of beta 3-adrenoceptor agonists. Also important are alternative routes of glucose disposal such as Na+-glucose cotransporter (SGLT) inhibitors, combination therapies, and the treatment of diabetic complications (eg. retinopathy, nephropathy, and neuropathy). With may new opportunities for drug discovery, the prospects are excellent for development of innovative therapies to effectively manage diabetes and prevent its long term complications. This review highlights recent (1997-2000) advances in diabetes therapy and research with an emphasis on small molecule drug design (275 references).

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“…Thiazolidinedione derivatives are activators of peroxisome proliferator‐activated receptor‐γ (PPAR‐γ), a member of the nuclear receptor superfamily shown to function in adipogenesis, which results in the an increase of the insulin sensitivity 28 . Treatment of GK rats with voglibose (an α‐glucosidase inhibitor) and with voglibose plus pioglitazone (a thiazolidinedione derivative) for 5 weeks significantly increased 16.7 mmol/L glucose‐induced insulin secretion compared with control GK rats 29 …”

Section: Discussionmentioning

confidence: 99%

Beneficial Effect Of T‐1095, A Selective Inhibitor Of Renal Na⁺–Glucose Cotransporters, On Metabolic Index And Insulin Secretion In Spontaneously Diabetic Gk Rats

Nunoi

Yasuda

Adachi

et al. 2002

Clin Exp Pharma Physio

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1. To investigate the pharmacological effects of T-1095, this novel derivative of phlorizin was administered to GK rats for 8 weeks. T-1095 treatment significantly lowered plasma glucose and glycosylated haemoglobin (HbA1c) levels, but did not significantly affect bodyweight. 2. T-1095 treatment did not affect 3.3 mmol/L glucose-induced insulin secretion in the isolated perfused pancreas of GK rats. 3. The peak insulin release in T-1095-treated GK rats was significantly higher during the first phase than in untreated GK rats (3-4 min after beginning 16.7 mmol/L glucose perfusion). The total amount of insulin secreted during the first phase in T-1095-treated GK rats was significantly higher than in untreated GK rats (35.3 +/- 1.4 vs. 27.3 +/- 2.5 ng in T-1095-treated compared with untreated rats, respectively). 4. During the second phase, insulin release in T-1095-treated GK rats was somewhat higher than in untreated GK rats (7-30 min after beginning 16.7 mmol/L glucose perfusion). The total amount of insulin secreted during the second phase in T-1095-treated GK rats was significantly higher than in untreated GK rats (88.2 +/- 6.1 vs. 68.1 +/- 5.7 ng, respectively). 5. The total amount of insulin secreted during perfusion in T-1095-treated GK rats was significantly higher than in untreated GK rats (123.5 +/- 7.3 vs. 95.4 +/- 7.7 ng, respectively). 6. These data show that the metabolic indices, plasma glucose and HbA1c levels and insulin secretion are significantly improved by T-1095 treatment in GK rats, which are spontaneously diabetic rats, suggesting its usefulness as a novel oral therapeutic antidiabetic agent.

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Beneficial Effect of Long-Term Combined Treatment with Voglibose and Pioglitazone on Pancreatic Islet Function of Genetically Diabetic GK Rats

Cited by 23 publications

References 8 publications

Halophilic Bacteria: Potentials and Applications in Biotechnology

Halophilic Bacteria: Potentials and Applications in Biotechnology

Current Therapies and Emerging Targets for the Treatment of Diabetes

Beneficial Effect Of T‐1095, A Selective Inhibitor Of Renal Na⁺–Glucose Cotransporters, On Metabolic Index And Insulin Secretion In Spontaneously Diabetic Gk Rats

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Beneficial Effect of Long-Term Combined Treatment with Voglibose and Pioglitazone on Pancreatic Islet Function of Genetically Diabetic GK Rats

Cited by 23 publications

References 8 publications

Halophilic Bacteria: Potentials and Applications in Biotechnology

Halophilic Bacteria: Potentials and Applications in Biotechnology

Current Therapies and Emerging Targets for the Treatment of Diabetes

Beneficial Effect Of T‐1095, A Selective Inhibitor Of Renal Na+–Glucose Cotransporters, On Metabolic Index And Insulin Secretion In Spontaneously Diabetic Gk Rats

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Beneficial Effect Of T‐1095, A Selective Inhibitor Of Renal Na⁺–Glucose Cotransporters, On Metabolic Index And Insulin Secretion In Spontaneously Diabetic Gk Rats