Beneficial Effect of Nutrisim© 
 against LPS-Induced Liver Injury: Oxidative Stress Markers and Mitochondrial 
 ATP-ase Activity

Hernandez-Andalon, Jose J.; Torres‐Sánchez, Erandis D.; Pacheco-Moisés, Fermín Paul; Romero-Tirado, Luís A.; Velázquez-Brizuela, Irma E.; Romero-Davalos, Rolando; Cruz-Ramos, José Alfonso; Ortiz, Genaro G.; Gonzalez-Renovate, E.D.

doi:10.3923/ijbc.2013.38.46

International J. of Biological Chemistry

2012

DOI: 10.3923/ijbc.2013.38.46

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Beneficial Effect of Nutrisim© against LPS-Induced Liver Injury: Oxidative Stress Markers and Mitochondrial ATP-ase Activity

Jose J. Hernandez-Andalon¹,

Erandis D. Torres‐Sánchez²,

Fermín Paul Pacheco-Moisés³

et al.

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2014

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Effect of Nutrisim© on Endotoxic Shock Induced by Lipopolysaccharide from Escherichia coli: 0111:B4 in Rats: Structural Study of Liver, Kidney and Lung

Renovato¹

2014

J Clin Exp Pathol

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Bacterial Lipopolysaccharide (LPS) is a glycolipid component of the cell wall of Gram-negative bacteria and is an endotoxin implicated in triggering sepsis and septic shock. Sepsis and its sequelae represent a continuum of clinical syndrome encompassing systemic inflammation, coagulopathy, abnormalities of the renal, hepatic, pulmonary, and hematologic systems followed by multi-organ failure. NutriSim©, a nutritional supplement, has previously been tested in an experimental model of septic shock; for example, a single dose of NutriSim© diminishes significantly the production of serum proinflammatory cytokines, attenuates the oxidative stress markers and preserves membrane fluidity in rat liver mitochondria. Therefore, the aim of the present study was to evaluate the protective effect of NutriSim© on survival and histological alterations in liver, kidney and lung associated with endotoxic shock induced by LPS. The results in this work showed that treatment with a single dose of NutriSim© 15 min prior or after LPS challenge, effectively protects the morphological damage in vital organs such as liver, kidney and lung, and improved the survival rate of LPS-treated rats. In conclusion, a single dose of NutriSim© in a septic shock model induced by LPS appears to effectively protect vital organ damage from morphological injury and reduces mortality.

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Effect of Nutrisim© on Endotoxic Shock Induced by Lipopolysaccharide from Escherichia coli: 0111:B4 in Rats: Structural Study of Liver, Kidney and Lung

Renovato¹

2014

J Clin Exp Pathol

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show abstract

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Beneficial Effect of Nutrisim© against LPS-Induced Liver Injury: Oxidative Stress Markers and Mitochondrial ATP-ase Activity

Cited by 1 publication

References 12 publications

Effect of Nutrisim© on Endotoxic Shock Induced by Lipopolysaccharide from Escherichia coli: 0111:B4 in Rats: Structural Study of Liver, Kidney and Lung

Effect of Nutrisim© on Endotoxic Shock Induced by Lipopolysaccharide from Escherichia coli: 0111:B4 in Rats: Structural Study of Liver, Kidney and Lung

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