Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy

Paredes, Sergio; Geralnik, Adela Ana Juknat de; Batlle, Alcira; Conti, Honorina

doi:10.1016/0020-711x(85)90295-2

Cited by 14 publications

(1 citation statement)

References 25 publications

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“…104,105 In addition, SAMe may increase glutathione-conjugated excretion of iron in bile, 106 the mechanism by which the molecule may aid in the reversal of lead poisoning. 107…”

Section: Pct In Childrenmentioning

confidence: 99%

Cutaneous porphyrias part II: treatment strategies

et al. 2013

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The porphyrias are diverse in pathophysiology, clinical presentation, severity, and prognosis, presenting a diagnostic and therapeutic challenge. Although not easily curable, the dermatological manifestations of these diseases, photosensitivity and associated cutaneous pathology, can be effectively prevented and managed. Sun avoidance is essential, and patient education regarding the irreversibility of photocutaneous damage is a necessary corollary. Beyond preventative measures, the care of fragile, vulnerable skin, and pain management, each of the porphyrias has a limited number of unique additional therapeutic options. Many of the treatments have been published only in small case series or anecdotal reports and do not have well-understood nor proven mechanisms of action. This article presents a comprehensive review of available therapeutic options and long-term management recommendations for the cutaneous porphyrias.

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“…104,105 In addition, SAMe may increase glutathione-conjugated excretion of iron in bile, 106 the mechanism by which the molecule may aid in the reversal of lead poisoning. 107…”

Section: Pct In Childrenmentioning

confidence: 99%

Cutaneous porphyrias part II: treatment strategies

et al. 2013

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S-Adenosyl-L-Methionine Prevents Intracellular Glutathione Depletion by GSH-Depleting Drugs in Rat and Human Hepatocytes

et al. 1992

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SummaryThis study examines the ability of externally added S-adenosyl-L-methionine (SAMe) to act as a precursor of intracellular glutathione (GSH) and to prevent the GSH depletion induced by paracetamol, opiates and ethanol in rat and human hepatocytes.Incubation of rat or human hepatocytes with SAMe 100 I'moljL as the only sulphur source in the medium resulted in a time-dependent elevation of intracellular GSH. Pretreatment of hepatocytes with SAMe resulted in a significant decrease in the cytotoxicity produced by exposure to paracetamol, heroin, methadone or ethanol, when compared with cultures not pretreated with SAMe. Preincubation of rat and human hepatocytes with SAMe attenuated the GSH depletion caused by paracetamol, heroin and methadone. In addition, the decrease in GSH resulting from exposure of hepatocytes to ethanol 50 mmol/L was prevented when SAMe was simultaneously added to cultures.These experimental results provide direct evidence that exogenously administered SAMe increases intracellular GSH levels in rat and human hepatocytes and prevents the GSH depletion caused by paracetamol, opiates and ethanol.

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Cytoprotective effect of S-adenosylmethionine compared with that of misoprostol against ethanol-, aspirin-, and stress-induced gastric damage

Laudanno

1987

The American Journal of Medicine

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Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy

Cited by 14 publications

References 25 publications

Cutaneous porphyrias part II: treatment strategies

Cutaneous porphyrias part II: treatment strategies

S-Adenosyl-L-Methionine Prevents Intracellular Glutathione Depletion by GSH-Depleting Drugs in Rat and Human Hepatocytes

Cytoprotective effect of S-adenosylmethionine compared with that of misoprostol against ethanol-, aspirin-, and stress-induced gastric damage

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