Beneficial Effect of Statin Therapy on Arterial Stiffness

Alidadi, Mona; Montecucco, Fabrizio; Jamialahmadi, Tannaz; Al-Rasadi, Khalid; Johnston, Thomas P.; Sahebkar, Amirhossein

doi:10.1155/2021/5548310

Cited by 26 publications

(20 citation statements)

References 132 publications

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“…However, the long-term effect by ACE or ARBs on pulse wave velocity is not clear. Similarly, studies have suggested, that statin treatment lowers aortic stiffness [ 18 , 19 ]. The exact mechanisms is not clear but reduction of the vascular remodeling and vascular tone in combination with reduced oxidative stress have been suggested [ 28 , 29 ].…”

Section: Resultsmentioning

confidence: 99%

Long-term effects of intensive multifactorial treatment on aortic stiffness and central hemodynamics after 13 years with screen-detected type 2 diabetes: the ADDITION-Denmark trial

Bjerg

Laugesen

Andersen

et al. 2022

Diabetol Metab Syndr

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Background Peripheral and central hemodynamic indices are modifiable by lifestyle and medical intervention. We aimed to determine the long-term effect of intensive multifactorial treatment on peripheral and central hemodynamic indices among people with screen-detected diabetes. Methods Between 2001 and 2006, people with screen-detected type 2 diabetes were included in the Anglo-Danish-Dutch study of Intensive Treatment of Diabetes in Primary Care (ADDITION) trial (NCT00237549, ClinicalTrials.gov). In the Danish arm, participants were invited to a clinical examination in 2015–2016, 13 years after inclusion and 8 years after trial-end. Out of 586 eligible participants who attended the clinical examination, 411 had a valid examination of central and peripheral hemodynamic indices (242 received intensive treatment and 169 received routine care). Carotid-femoral pulse wave velocity (cfPWV), central blood pressure and augmentation index were assessed by applanation tonometry. We used mixed-effect models to examine the intervention effect adjusting for cluster randomization and heart rate. Results Randomization to intensive treatment during the trial-period was associated with a 0.58 m/s lower cfPWV (95% CI − 1.09 to − 0.06) at follow-up. Adjustment for blood pressure attenuated the association. Differences between intervention groups for central augmentation index were − 1.25% (95% CI: − 3.28 to 0.78), central pulse pressure − 1.74 mmHg (95% CI − 4.79 to 1.31), central systolic blood pressure − 3.06 mmHg (− 7.08 to 0.96), and central diastolic blood pressure − 1.70 mmHg (− 3.74 to 0.34). Conclusions Intensive multifactorial treatment of screen-detected type 2 diabetes has a sustained positive effect on aortic stiffness measured by cfPWV. Although all estimates pointed in favor of intensive treatment, we observed no clear beneficial effect on other hemodynamic indices.

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Section: Resultsmentioning

confidence: 99%

Long-term effects of intensive multifactorial treatment on aortic stiffness and central hemodynamics after 13 years with screen-detected type 2 diabetes: the ADDITION-Denmark trial

Bjerg

Laugesen

Andersen

et al. 2022

Diabetol Metab Syndr

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“… 14 , 45 Moreover, statins could reduce endothelial dysfunction, improve vascular remodeling, and stabilize atherosclerotic plaque. 8 , 46…”

Section: Discussionmentioning

confidence: 99%

“… 3 , 4 , 5 Statins, the first-line lipid-lowering therapies used widely to prevent CVD, 6 , 7 serve as a promising pharmacological strategy to improve arterial stiffness. However, recent reviews reported inconsistent findings regarding the association between statin use and arterial stiffness, with some studies 8 , 9 showing positive effects and others reporting null effects. The robustness of the evidence was limited by relatively small sample sizes (generally <100) 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 and short-term follow-up durations (generally ≤6 months).…”

Section: Introductionmentioning

confidence: 99%

Association Between Statin Use and Progression of Arterial Stiffness Among Adults With High Atherosclerotic Risk

Zhou

Wang

et al. 2022

JAMA Netw Open

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“…For a long time, statins have been prescribed for patients with higher levels of cholesterol, LDL-C, and hypertriglyceridemia in patients with cardiovascular disorders and diabetes [17,18]. However, the current line of evidence has shown that statins have numerous lipid-independent (pleiotropic) actions [19][20][21][22][23][24][25][26]. Among the pleiotropic effects of statins is modulation of autophagy in various cells, providing a promising therapeutic strategy in treating disorders with impaired autophagy as primary underlying pathogenesis [27,28].…”

Section: Introductionmentioning

confidence: 99%

Implications on the Therapeutic Potential of Statins via Modulation of Autophagy

Gorabi

Kiaie

Aslani

et al. 2021

Oxidative Medicine and Cellular Longevity

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Statins, which are functionally known as 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) inhibitors, are lipid-lowering compounds widely prescribed in patients with cardiovascular diseases (CVD). Several biological and therapeutic functions have been attributed to statins, including neuroprotection, antioxidation, anti-inflammation, and anticancer effects. Pharmacological characteristics of statins have been attributed to their involvement in the modulation of several cellular signaling pathways. Over the past few years, the therapeutic role of statins has partially been attributed to the induction of autophagy, which is critical in maintaining cellular homeostasis and accounts for the removal of unfavorable cells or specific organelles within cells. Dysregulated mechanisms of the autophagy pathway have been attributed to the etiopathogenesis of various disorders, including neurodegenerative disorders, malignancies, infections, and even aging. Autophagy functions as a double-edged sword during tumor metastasis. On the one hand, it plays a role in inhibiting metastasis through restricting necrosis of tumor cells, suppressing the infiltration of the inflammatory cell to the tumor niche, and generating the release of mediators that induce potent immune responses against tumor cells. On the other hand, autophagy has also been associated with promoting tumor metastasis. Several anticancer medications which are aimed at inducing autophagy in the tumor cells are related to statins. This review article discusses the implications of statins in the induction of autophagy and, hence, the treatment of various disorders.

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Beneficial Effect of Statin Therapy on Arterial Stiffness

Cited by 26 publications

References 132 publications

Long-term effects of intensive multifactorial treatment on aortic stiffness and central hemodynamics after 13 years with screen-detected type 2 diabetes: the ADDITION-Denmark trial

Long-term effects of intensive multifactorial treatment on aortic stiffness and central hemodynamics after 13 years with screen-detected type 2 diabetes: the ADDITION-Denmark trial

Association Between Statin Use and Progression of Arterial Stiffness Among Adults With High Atherosclerotic Risk

Implications on the Therapeutic Potential of Statins via Modulation of Autophagy

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