Beneficial Effects of Acanthopanax senticosus Extract in Type II Diabetes Animal Model via Down-Regulation of Advanced Glycated Hemoglobin and Glycosylation End Products

권한올,; 이민희,; 김용재,; 김은,; 김옥경,

doi:10.3746/jkfn.2016.45.7.929

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…However, the stems showed a high inhibitory capacity despite its low content of these components, which may be related to other components within the stems. In fact, the stem extracts and eleutheroside E, the main component in stems, showed potent anti-diabetic activity in mouse models of type 1 or 2 diabetes [75][76][77] .…”

Section: Inhibitory Activity Of the Methanol Extract And Triterpenoid...mentioning

confidence: 99%

Comprehensive profiling of phenolic compounds and triterpenoid saponins from Acanthopanax senticosus and their antioxidant, α-glucosidase inhibitory activities

Kwon,

Na,

Kim

et al. 2024

Preprint

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Acanthopanax senticosus belongs to Araliaceae family and is traditionally used as a tonic. The roots and stems are mainly used as a treatment for hypodynamia, rheumatism, and hypertension, but their frequent use may lead to its extinction. However, comprehensive and simultaneous analysis of the remaining parts were still limited, and needs to reorganize for standardization of functional foods. In this study, 50 phenolic compounds and 82 triterpenoid saponins from the shoots, leaves, fruits, and stems of A. senticosus were characterized using UPLC-QTOF-MS and UPLC-QTRAP-MS/MS. Among them, 57 new compounds were detected as the cis and malonyl-bound phenolic acids and were structural isomers of Acanthopanax flavonoids and saponins. All compounds were absolutely/relatively quantified, and shoots had the highest content. Antioxidant and α-glucosidase inhibitory activity were performed, followed by evaluation of structure-activity relationships. Both activities of all tested extracts and saponins showed remarkable efficacy and affected by the C-23 hydroxylation, the C-20(29) double bond, and the presence of rhamnose. These detailed profiling can be used as fundamental data for increasing the utilization of A. senticosus and developing them into functional foods.

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Section: Inhibitory Activity Of the Methanol Extract And Triterpenoid...mentioning

confidence: 99%

Comprehensive profiling of phenolic compounds and triterpenoid saponins from Acanthopanax senticosus and their antioxidant, α-glucosidase inhibitory activities

Kwon,

Na,

Kim

et al. 2024

Preprint

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show abstract

“…The incidence of type 2 diabetes has risen since lifestyle changes tend to lack of physical activity and excessive nutrition, leading to obesity. Type 2 diabetes is known to cause complications such as diabetic retinopathy, osteoporosis, and various cardiovascular diseases (Katsuda et al, 2013;Kwon et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Investigation Potential Antidiabetic Activity of Angelica gigas Nakai Leaf Extract

Lee,

Taufik,

Lim

et al. 2024

Preprint

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This study was conducted to investigate Angelica gigas Nakai leaf extract (ALE) as an antidiabetic. The inhibitory activity of ALE on α-glucosidase inhibition and rat intestinal disaccharidase were measured. Also, its effect on glucose uptake in 3T3-L1 cells was analyzed. Supplementation of ALE up to 150µg/mL showed cell viability higher than 90% in 3T3-L1 cells. The 60% and 80% of ethanol ALE revealed the highest α-glucosidase inhibitory activity. Further, the 60% ethanol ALE extracts were freeze-dried (FD60) and spray-dried (SD60) to evaluate their antidiabetic effects. The α-glucosidase inhibitory assay revealed that the IC50 of SD60 and FD60 were 4.08 mg/mL and 2.93 mg/mL, respectively. A Lineweaver-Burk plot showed that ALE demonstrates mixed-type inhibition. FD60 and SD60 showed no significant difference in inhibiting maltase, sucrase, and glucoamylase of rat intestinal disaccharidase. FD60 and SD60 significantly (p < 0.05) increased insulin-stimulated glucose uptake in 3T3-L1 cells compared to D-pinitol. Moreover, ALE could increase the expression of pAkt Thr308 in Vero 76 cells via western blot analysis. These findings suggest that ALE has potential antidiabetic properties.

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Comprehensive profiling of phenolic compounds and triterpenoid saponins from Acanthopanax senticosus and their antioxidant, α-glucosidase inhibitory activities

Kwon,

Na,

Kim

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Beneficial Effects of Acanthopanax senticosus Extract in Type II Diabetes Animal Model via Down-Regulation of Advanced Glycated Hemoglobin and Glycosylation End Products

Cited by 4 publications

References 22 publications

Comprehensive profiling of phenolic compounds and triterpenoid saponins from Acanthopanax senticosus and their antioxidant, α-glucosidase inhibitory activities

Comprehensive profiling of phenolic compounds and triterpenoid saponins from Acanthopanax senticosus and their antioxidant, α-glucosidase inhibitory activities

Investigation Potential Antidiabetic Activity of Angelica gigas Nakai Leaf Extract

Comprehensive profiling of phenolic compounds and triterpenoid saponins from Acanthopanax senticosus and their antioxidant, α-glucosidase inhibitory activities

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