Beneficial effects of Aesculus hippocastanum L. seed extract on the body's own antioxidant defense system on subacute administration

Küçükkurt, İ̇smail; İnce, Sinan; Keleş, Hikmet; Akkol, Esra Küpeli; Avcı, Gülcan; Yeşilada, Erdem; Bacak, Elif

doi:10.1016/j.jep.2010.02.017

Cited by 57 publications

(32 citation statements)

References 37 publications

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“…The fruit contains carbohydrates, fibers, starch, proteins, lipids, vitamins (A, B, K), glycosides and coumarin . It has been used as food, for medicinal purposes to treat inflammatory and vascular problems, as an analgesic and anti‐burning agent …”

Section: Introductionmentioning

confidence: 99%

Lipid composition of Castanea sativa Mill. and Aesculus hippocastanum fruit oils

et al. 2012

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Section: Introductionmentioning

confidence: 99%

Lipid composition of Castanea sativa Mill. and Aesculus hippocastanum fruit oils

et al. 2012

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“…As sementes são utilizadas para tratamento de problemas vasculares e inflamatórios. Na medicina tradicional da Turquia, o chá preparado das sementes era usado para o tratamento de pedras nos rins e dores estomacais, enquanto uma fração da semente era engolida para melhorar os sintomas de hemorroidas (13).…”

Section: Resultsunclassified

Estudos Pré-Clínicos E Clínicos De Espécies Vegetais Selecionadas De Países Pertencentes Ao Mercosul E Aspectos Toxicológicos

Cechinel-Zanchett¹

2017

Infarma

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Medicinal plants are used to prevent and treat diseases and have been used by about 80% of the population for primary health care. The rich biodiversity of Brazil and neighboring Countries offers a unique and unparalleled potential for the discovery and development of bioactive agents. This study aimed to do a review of preclinical and clinical studies of herbal and plant species selected from Mercosul countries, and toxicological aspects. Based on previous work, the species with the highesAt number of register in Brazil (Anvisa), Aesculus hippocastanum (Horse Chestnut) and Mikania glomerata (Guaco); the most used as simple herbal medicines in Argentina Cynara scolymus L. (Artichoke) and Solanum dulcamara (Dulcamara); the sold medicinal plants in Paraguay Peumus boldus Mol. (Bilberry), and Borago officinalis (Borage); the most consumed in northern Uruguay Aloe vera (Aloe) and Passiflora edulis (Passion flower) and from Venezuela, Hedera helix (Hera) were selected for a review about pharmacology studies. Surveys on pre-clinical and clinical trials of these species were conducted on Google Scholar, PubMed and Science Direct databases in April 2016, in Portuguese and English. Then the most relevant articles were selected, using animals (rats, rabbits or mice), cellular or bacterial strains or clinical trials. About preclinical and clinical studies, Aloe and Artichoke showed the most substantial number of publications.Keywords: phytotherapy; Mercosul; medicinal plants RESUMOAs plantas medicinais são utilizadas para a prevenção e tratamento de doenças, sendo usada por cerca de 80% da população para o cuidado primário à saúde. A rica biodiversidade do Brasil e países vizinhos oferece um potencial único e incomparável para a descoberta e desenvolvimento de agentes bioativos. O objetivo desse trabalho foi fazer uma revisão sobre estudos pré-clínicos e clínicos de espécies vegetais selecionadas dos países do Mercosul e aspectos toxicológicos. Com base em trabalho publicado anteriormente pelo autor, foram selecionadas as espécies com maior nú-mero de registro na Anvisa no Brasil (Aesculus hippocastanum -Castanha da Índia e Mikania glomerata-Guaco); as mais utilizadas como medicamentos fitoterápicos simples na Argentina (Cynara scolymus L. -Alcachofra e Solanum dulcamara -Dulcamara); as plantas medicinais mais vendidas no Paraguai (Peumus boldus Mol. -Boldo e Borago officinalis -Borragem); as mais consumidas no norte do Uruguai (Aloe vera -Aloe e Passiflora edulis -Maracujá) e da Venezuela a Hedera helix (Hera) por ser muito popular no país seu consumo. Foram realizadas pesquisas nas bases de dados Google Acadêmico, PubMed e Science Direct no mês de abril de 2016, sobre ensaios pré-clínicos e clínicos dessas espécies vegetais, em português e inglês, sendo selecionados os artigos mais relevantes, com uso de animais (ratos, coelhos ou camundongos), linhagens celulares ou bacterianas, ou estudos clínicos. Em relação aos estudos pré-clínicos e clínicos, Aloe e Alcachofra, foram as que apresentaram maior número de publi...

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“…However, under pathological conditions, the development of tissue injury probably depends on the balance of the generation of reactive oxygen species and the tissues antioxidant defense mechanism. Complexes of free radical scavenging enzymes, including SOD, CAT and GSH-PX, have evolved to prevent excessive oxidant stress [21,22]. Studies of Alagarraju Muthukumar indicated that mitochondrial dysfunction resulting from GSH depletion could be a contributing factor in the development of calcium oxalate stones [23].…”

Section: Resultsmentioning

confidence: 99%

The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage

Zhang

Kong

et al. 2013

Marine Drugs

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The aim of the present study is to evaluate the protective effect of polysaccharide from the Brown Seaweed Sargassum graminifolium (SGP) on ethylene glycol-induced kidney damage and the mechanism of SGP-mediated protection. Mitochondrial lipid peroxidation, mitochondrial swelling, the activity of succinate dehydrogenase (SDH), ATPases and mitochondrial antioxidant enzymes was observed in hyperoxaluric rats. Administration of SGP (25, 100 and 400 mg·kg−1, intragastrically) increased the activities of antioxidant enzymes, SDH and Na+/K+-ATPases, Ca2+-ATPases, Mg2+-ATPases, also decreased mitochondrial lipid peroxidation and mitochondrial swelling. SGP exhibited a protective effect by improving antioxidant enzymes and restoring mitochondrial dysfunction in the kidney of hyperoxaluric rats. It may be used as a promising therapeutic agent to provide superior renal protection.

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Beneficial effects of Aesculus hippocastanum L. seed extract on the body's own antioxidant defense system on subacute administration

Cited by 57 publications

References 37 publications

Lipid composition of Castanea sativa Mill. and Aesculus hippocastanum fruit oils

Lipid composition of Castanea sativa Mill. and Aesculus hippocastanum fruit oils

Estudos Pré-Clínicos E Clínicos De Espécies Vegetais Selecionadas De Países Pertencentes Ao Mercosul E Aspectos Toxicológicos

The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifolium against Ethylene Glycol-Induced Mitochondrial Damage

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